Abstract
Granuloma formation in the skin, lung and many other organs is the major manifestation of sarcoidosis. This condition is accompanied with reduced organ function leading to diminished life quality and system failure. It has been hypothesized that Mycobacterium tuberculosis and/or C. acnes might be involved in its etiology. For both species granulomatose formation is demonstrated in in vitro cultures and in histological specimens. Recently, granuloma formation orthologs between M. tuberculosis and Yersinia pseudotuberculosis were identified (Aswal M. et al. Sci Rep. 2020; 10(1):3036). The aim of this study was to identify orthologs involved in granuloma formation in C. acnes. We applied comparative analysis on translated coding sequences of M. tuberculosis, Y. pseudotuberculosis and C. acnes using OrthoVenn2. A total of 6272 genes were analysed of which only 2 were orthologs: the replication initiator P9WNW2 and the 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (P9WKG0). The latter is involved in a non-mevalonate pathway and is described as a viral factor in tuberculosis. This supports the notion that granuloma formation in sarcoidosis can be induced by a number of different microbes .
Acknowledgement: This work was supported by the National Science Programme VIHREN and the Bulgarian National Science Fund (BNSF) with grant N: KP-06-DB/10 - 21.12.2019
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, OA3981.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
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