Late Breaking Abstract - Value of the interleukin profile can be an objective standart for control  the tactics of managing patients with bronchiolitis

Abstract

Introduction: Bronchiolitis is one of the most common lower respiratory tract infections that affects infants worldwide. In Europe, the estimated annual hospitalization rate for bronchiolitis in 2015 was 46.1 per 1,000 infants. Between 2005 and 2015, these figures grew by an average of 1.7% per year. Despite the high prevalence of bronchiolitis, it is a clinical diagnosis without a single international definition. Indicators of the interleukin profile can be an objective criterion for monitoring the management tactics of patients with bronchiolitis.

Materials and methods. The survey included 24 children with a clinically established diagnosis of bronchiolitis at the age from 1 to 7 months. All the patients in the acute stage of the disease were tested for the concentration of interleukins 6, 4 and 18 in blood.

Results: Children with grade 2 respiratory distress index, the average IL 6 is 4.2 pg / ml, IL 4 - 0.36 pg / ml, IL 18 - 1737.27 pg / ml, with with grade 1 respiratory distress index is average IL 6 - 10.07 pg / ml, IL 4 - 1.3 pg / ml, IL 18 - 1147.59 pg / ml, without respiratory failure IL 6 - 25.59 pg / ml, IL 4 - 2.39 pg / ml, IL 18 - 612.85 pg / ml. A positive correlation was found between IL18 and the degree of respiratory distress p + 0.86.

In patients with a diagnosis of bronchiolitis, depending on the severity of respiratory failure, pronounced changes in the cytokine profile: an increase in the concentration of Il-18 and a decrease in Il-4. These changes are an important objective label for choosing the tactics of managing these patients and predicting a possible deterioration of the degree of respiratory failure.