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Table of Contents

01 December 2021; volume 58, issue 6

Editorials

  • You have accessRestricted access
    Clean air for healthy lungs – an urgent call to action: European Respiratory Society position on the launch of the WHO 2021 Air Quality Guidelines
    Zorana Jovanovic Andersen, Ulrike Gehring, Sara De Matteis, Erik Melen, Ana Maria Vicedo-Cabrera, Klea Katsouyanni, Arzu Yorgancioglu, Charlotte Suppli Ulrik, Sylvia Medina, Kjeld Hansen, Pippa Powell, Brian Ward, Barbara Hoffmann
    European Respiratory Journal 58 (6) 2102447; DOI: 10.1183/13993003.02447-2021 Published 2 December 2021
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    Evolving diagnostic techniques in mediastinal lymphadenopathy: is mediastinal cryobiopsy the new kid on the block?
    Reinier R.L. Wener, Paul E. Van Schil
    European Respiratory Journal 58 (6) 2101496; DOI: 10.1183/13993003.01496-2021 Published 9 December 2021
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    Primary nasal epithelial cells from patients with cystic fibrosis hold promise for guiding precision medicine and expanding treatment
    Stephen R. Reeves
    European Respiratory Journal 58 (6) 2102735; DOI: 10.1183/13993003.02735-2021 Published 2 December 2021
  • Open Access
    Interstitial lung disease before and after COVID-19: a double threat?
    Claudia Valenzuela, Grant Waterer, Ganesh Raghu
    European Respiratory Journal 58 (6) 2101956; DOI: 10.1183/13993003.01956-2021 Published 2 December 2021
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    Less is more? Antibiotic treatment duration for exacerbations of bronchiectasis
    James D. Chalmers, Holly R. Keir
    European Respiratory Journal 58 (6) 2101416; DOI: 10.1183/13993003.01416-2021 Published 16 December 2021
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    Using placebo-controlled trials to define predictors of future exacerbations in severe asthma patients
    Andriana I. Papaioannou, Andreas Photiades, Mina Gaga
    European Respiratory Journal 58 (6) 2101702; DOI: 10.1183/13993003.01702-2021 Published 16 December 2021
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    Identifying and addressing health inequalities in asthma care
    Dermot Ryan, Ian Sabroe
    European Respiratory Journal 58 (6) 2101829; DOI: 10.1183/13993003.01829-2021 Published 16 December 2021
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    Distinguishing causation from genetic correlation in a Mendelian randomisation framework
    Dipender Gill, Stephen Burgess
    European Respiratory Journal 58 (6) 2101346; DOI: 10.1183/13993003.01346-2021 Published 9 December 2021
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    Targeting AMPK and the Nrf2/HO-1 axis: a promising therapeutic strategy in acute lung injury
    Stefan W. Ryter
    European Respiratory Journal 58 (6) 2102238; DOI: 10.1183/13993003.02238-2021 Published 23 December 2021

ERS Official Documents

  • ERS guidelines

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      ERS clinical practice guidelines on treatment of sarcoidosis
      Robert P. Baughman, Dominique Valeyre, Peter Korsten, Alexander G. Mathioudakis, Wim A. Wuyts, Athol Wells, Paola Rottoli, Hiliaro Nunes, Elyse E. Lower, Marc A. Judson, Dominique Israel-Biet, Jan C. Grutters, Marjolein Drent, Daniel A. Culver, Francesco Bonella, Katerina Antoniou, Filippo Martone, Bernd Quadder, Ginger Spitzer, Blin Nagavci, Thomy Tonia, David Rigau, Daniel R. Ouellette
      European Respiratory Journal 58 (6) 2004079; DOI: 10.1183/13993003.04079-2020 Published 16 December 2021

Original Research Articles

  • Clinical practice

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      Transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions: a randomised trial
      Jing Zhang, Jie-Ru Guo, Zan-Sheng Huang, Wan-Lei Fu, Xian-Li Wu, Na Wu, Wolfgang M. Kuebler, Felix J.F. Herth, Ye Fan
      European Respiratory Journal 58 (6) 2100055; DOI: 10.1183/13993003.00055-2021 Published 9 December 2021
  • Cystic fibrosis

    • Open Access
      Theratyping cystic fibrosis in vitro in ALI culture and organoid models generated from patient-derived nasal epithelial conditionally reprogrammed stem cells
      Giovanni Sette, Stefania Lo Cicero, Giovanna Blaconà, Silvia Pierandrei, Sabina Maria Bruno, Valentina Salvati, Germana Castelli, Mario Falchi, Benedetta Fabrizzi, Giuseppe Cimino, Ruggero De Maria, Mauro Biffoni, Adriana Eramo, Marco Lucarelli
      European Respiratory Journal 58 (6) 2100908; DOI: 10.1183/13993003.00908-2021 Published 2 December 2021
  • Interstitial lung disease

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      Serum levels of small HDL particles are negatively correlated with death or lung transplantation in an observational study of idiopathic pulmonary fibrosis
      Amisha V. Barochia, Maryann Kaler, Nargues Weir, Elizabeth M. Gordon, Debbie M. Figueroa, Xianglan Yao, Merte Lemma WoldeHanna, Maureen Sampson, Alan T. Remaley, Geraldine Grant, Scott D. Barnett, Steven D. Nathan, Stewart J. Levine
      European Respiratory Journal 58 (6) 2004053; DOI: 10.1183/13993003.04053-2020 Published 2 December 2021
  • Interstitial lung disease and rare lung disease

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      Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis
      Milica Vukmirovic, Xiting Yan, Kevin F. Gibson, Mridu Gulati, Jonas C. Schupp, Giuseppe DeIuliis, Taylor S. Adams, Buqu Hu, Antun Mihaljinec, Tony N. Woolard, Heather Lynn, Nkiruka Emeagwali, Erica L. Herzog, Edward S. Chen, Alison Morris, Joseph K. Leader, Yingze Zhang, Joe G.N. Garcia, Lisa A. Maier, Ronald G. Collman, Wonder P. Drake, Michael J. Becich, Harry Hochheiser, Steven R. Wisniewski, Panayiotis V. Benos, David R. Moller, Antje Prasse, Laura L. Koth, Naftali Kaminski on behalf of the GRADS Investigators
      European Respiratory Journal 58 (6) 2002950; DOI: 10.1183/13993003.02950-2020 Published 2 December 2021
  • Interstitial lung disease and COVID-19

    • Open Access
      Interstitial lung disease increases susceptibility to and severity of COVID-19
      Hyun Lee, Hayoung Choi, Bumhee Yang, Sun-Kyung Lee, Tai Sun Park, Dong Won Park, Ji-Yong Moon, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon, Sang-Heon Kim
      European Respiratory Journal 58 (6) 2004125; DOI: 10.1183/13993003.04125-2020 Published 2 December 2021
  • COVID-19

    • Open Access
      Chronic respiratory diseases are predictors of severe outcome in COVID-19 hospitalised patients: a nationwide study
      Guillaume Beltramo, Jonathan Cottenet, Anne-Sophie Mariet, Marjolaine Georges, Lionel Piroth, Pascale Tubert-Bitter, Philippe Bonniaud, Catherine Quantin
      European Respiratory Journal 58 (6) 2004474; DOI: 10.1183/13993003.04474-2020 Published 9 December 2021
  • Tuberculosis

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      Performance of Xpert MTB/RIF Ultra for tuberculosis diagnosis in the context of passive and active case finding
      Belén Saavedra, Edson Mambuque, Dinis Nguenha, Neide Gomes, Shilzia Munguambe, Juan Ignacio García, Santiago Izco, Sozinho Acacio, Adrià Murias-Closas, Marta Cossa, Irene Losada, Hadrián Pernas-Pardavila, Laura Oliveras, Grant Theron, Alberto L. García-Basteiro
      European Respiratory Journal 58 (6) 2100257; DOI: 10.1183/13993003.00257-2021 Published 23 December 2021
  • Respiratory infections

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      Feasibility of shortening intravenous antibiotic therapy for bronchiectasis based on bacterial load: a proof-of-concept randomised controlled trial
      Pallavi Bedi, Manjit K. Cartlidge, Yang Zhang, Kim Turnbull, Samantha Donaldson, Andrea Clarke, Jane Crowe, Kadiga Campbell, Catriona Graham, Ruzanna Franguylan, Adriano G. Rossi, Adam T. Hill
      European Respiratory Journal 58 (6) 2004388; DOI: 10.1183/13993003.04388-2020 Published 16 December 2021
  • Pulmonary vascular disease

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      Evolution of CT findings after anticoagulant treatment for acute pulmonary embolism in patients with and without an ultimate diagnosis of chronic thromboembolic pulmonary hypertension
      Natalia J. Braams, Gudula J.A.M. Boon, Frances S. de Man, Josien van Es, Paul L. den Exter, Lucia J.M. Kroft, Ludo F.M. Beenen, Menno V. Huisman, Esther J. Nossent, Anco Boonstra, Anton Vonk Noordegraaf, Dieuwertje Ruigrok, Frederikus A. Klok, Harm Jan Bogaard, Lilian J. Meijboom
      European Respiratory Journal 58 (6) 2100699; DOI: 10.1183/13993003.00699-2021 Published 23 December 2021
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      Role of angiopoietin-2 in venous thrombus resolution and chronic thromboembolic disease
      Lukas Hobohm, Sebastian Kölmel, Caroline Niemann, Philipp Kümpers, Valentin J. Krieg, Magdalena L. Bochenek, Alexander H. Lukasz, Yvonne Reiss, Karl-Heinz Plate, Christoph Liebetrau, Christoph B. Wiedenroth, Stefan Guth, Thomas Münzel, Gerd Hasenfuß, Philip Wenzel, Eckhard Mayer, Stavros V. Konstantinides, Katrin Schäfer, Mareike Lankeit
      European Respiratory Journal 58 (6) 2004196; DOI: 10.1183/13993003.04196-2020 Published 2 December 2021
  • Lung structure and function

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      Occupational inhalant exposures and longitudinal lung function decline
      Stinna Skaaby, Esben Meulengracht Flachs, Peter Lange, Vivi Schlünssen, Jacob Louis Marott, Charlotte Brauer, Yunus Çolak, Shoaib Afzal, Børge G. Nordestgaard, Steven Sadhra, Om Kurmi, Jens Peter Ellekilde Bonde
      European Respiratory Journal 58 (6) 2004341; DOI: 10.1183/13993003.04341-2020 Published 2 December 2021
  • Asthma

    • You have accessRestricted access
      Patient characteristics, biomarkers and exacerbation risk in severe, uncontrolled asthma
      Monica Kraft, Guy Brusselle, J. Mark FitzGerald, Ian D. Pavord, Matthew Keith, Malin Fagerås, Esther Garcia Gil, Ian Hirsch, Mitchell Goldman, Gene Colice
      European Respiratory Journal 58 (6) 2100413; DOI: 10.1183/13993003.00413-2021 Published 16 December 2021
    • You have accessRestricted access
      Socioeconomic biases in asthma control and specialist referral of possible severe asthma
      Kjell Erik Julius Håkansson, Vibeke Backer, Charlotte Suppli Ulrik
      European Respiratory Journal 58 (6) 2100741; DOI: 10.1183/13993003.00741-2021 Published 16 December 2021
    • You have accessRestricted access
      COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE therapy
      Markus Weckmann, Thomas Bahmer, Jannie Marie Sand, Sarah Rank Rønnow, Martin Pech, Cornelis Vermeulen, Alen Faiz, Diana Julie Leeming, Morten Asser Karsdal, Lars Lunding, Brian George G. Oliver, Michael Wegmann, Gudrun Ulrich-Merzenich, Uwe R. Juergens, Jannis Duhn, Yves Laumonnier, Olga Danov, Katherina Sewald, Ulrich Zissler, Marnix Jonker, Inke König, Gesine Hansen, Erika von Mutius, Oliver Fuchs, Anna-Maria Dittrich, Bianca Schaub, Christine Happle, Klaus F. Rabe, Maarten van de Berge, Janette Kay Burgess, Matthias Volkmar Kopp the ALLIANCE Study Group as part of the German Centre for Lung Research (DZL)
      European Respiratory Journal 58 (6) 2003969; DOI: 10.1183/13993003.03969-2020 Published 9 December 2021
  • COPD and asthma

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      Kidney function and obstructive lung disease: a bidirectional Mendelian randomisation study
      Sehoon Park, Soojin Lee, Yaerim Kim, Semin Cho, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
      European Respiratory Journal 58 (6) 2100848; DOI: 10.1183/13993003.00848-2021 Published 9 December 2021
  • COPD

    • You have accessRestricted access
      Long-term air pollution and road traffic noise exposure and COPD: the Danish Nurse Cohort
      Shuo Liu, Youn-Hee Lim, Marie Pedersen, Jeanette T. Jørgensen, Heresh Amini, Thomas Cole-Hunter, Amar J. Mehta, Rina So, Laust H. Mortensen, Rudi G.J. Westendorp, Steffen Loft, Elvira V. Bräuner, Matthias Ketzel, Ole Hertel, Jørgen Brandt, Steen S. Jensen, Jesper H. Christensen, Torben Sigsgaard, Camilla Geels, Lise M. Frohn, Maja Brboric´, Jelena Radonic´, Maja Turk Sekulic, Klaus Bønnelykke, Claus Backalarz, Mette K. Simonsen, Zorana J. Andersen
      European Respiratory Journal 58 (6) 2004594; DOI: 10.1183/13993003.04594-2020 Published 2 December 2021
  • Basic science and interstitial lung disease

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      Fibroblasts positive for meflin have anti-fibrotic properties in pulmonary fibrosis
      Yoshio Nakahara, Naozumi Hashimoto, Koji Sakamoto, Atsushi Enomoto, Taylor S. Adams, Toyoharu Yokoi, Norihito Omote, Sergio Poli, Akira Ando, Keiko Wakahara, Atsushi Suzuki, Masahide Inoue, Akitoshi Hara, Yasuyuki Mizutani, Kazuyoshi Imaizumi, Tsutomu Kawabe, Ivan O. Rosas, Masahide Takahashi, Naftali Kaminski, Yoshinori Hasegawa
      European Respiratory Journal 58 (6) 2003397; DOI: 10.1183/13993003.03397-2020 Published 23 December 2021
  • Basic science and acute lung injury

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      AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1
      Israr Ahmad, Adam Molyvdas, Ming-Yuan Jian, Ting Zhou, Amie M. Traylor, Huachun Cui, Gang Liu, Weifeng Song, Anupam Agarwal, Tamas Jilling, Saurabh Aggarwal, Sadis Matalon
      European Respiratory Journal 58 (6) 2003694; DOI: 10.1183/13993003.03694-2020 Published 23 December 2021

Reviews

  • Open Access
    A contemporary practical approach to the multidisciplinary management of unclassifiable interstitial lung disease
    Christopher J. Ryerson, Tamera J. Corte, Jeffrey L. Myers, Simon L.F. Walsh, Sabina A. Guler
    European Respiratory Journal 58 (6) 2100276; DOI: 10.1183/13993003.00276-2021 Published 16 December 2021
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    The effectiveness of contact investigation among contacts of tuberculosis patients: a systematic review and meta-analysis
    Kavindhran Velen, Rashmi Vijay Shingde, Jennifer Ho, Greg James Fox
    European Respiratory Journal 58 (6) 2100266; DOI: 10.1183/13993003.00266-2021 Published 9 December 2021

Agora

  • Research letters

    • Open Access
      Saliva molecular testing for SARS-CoV-2: simplifying the diagnosis without losing accuracy
      Francesca Saluzzo, Paola Mantegani, Valeria Poletti de Chaurand, Federica Cugnata, Patrizia Rovere-Querini, Marta Cilla, Patrizia Paola Erba, Sara Racca, Cristina Tresoldi, Caterina Uberti-Foppa, Clelia Di Serio, Daniela Maria Cirillo
      European Respiratory Journal 58 (6) 2102099; DOI: 10.1183/13993003.02099-2021 Published 23 December 2021
    • Open Access
      Outcomes over the first two years of treatment with mepolizumab in severe asthma
      Lynn Elsey, Thomas Pantin, Leanne-Jo Holmes, Gael Tavernier, Stephen J. Fowler
      European Respiratory Journal 58 (6) 2101313; DOI: 10.1183/13993003.01313-2021 Published 23 December 2021
    • You have accessRestricted access
      Epigenetic blood biomarkers of ageing and mortality in COPD
      Ana I. Hernandez Cordero, Chen Xi Yang, Stephen Milne, Xuan Li, Zsuzsanna Hollander, Virginia Chen, Raymond Ng, Scott J. Tebbutt, Janice M. Leung, Don D. Sin
      European Respiratory Journal 58 (6) 2101890; DOI: 10.1183/13993003.01890-2021 Published 16 December 2021
    • You have accessRestricted access
      The prognostic role of matrix metalloproteinase-7 in scleroderma-associated interstitial lung disease
      Scott M. Matson, Seoyeon J. Lee, Ryan A. Peterson, Natalia A. Achtar-Zadeh, Francesco Boin, Paul J. Wolters, Joyce S. Lee
      European Respiratory Journal 58 (6) 2101560; DOI: 10.1183/13993003.01560-2021 Published 9 December 2021
    • You have accessRestricted access
      Circulating fibrocytes as a new tool to predict lung cancer progression after surgery?
      Pauline Henrot, Fabien Beaufils, Matthieu Thumerel, Edmée Eyraud, Augustin Boudoussier, Hugues Begueret, Elise Maurat, Pierre-Olivier Girodet, Roger Marthan, Patrick Berger, Isabelle Dupin, Maéva Zysman
      European Respiratory Journal 58 (6) 2101221; DOI: 10.1183/13993003.01221-2021 Published 9 December 2021
    • Open Access
      Automated lung sound analysis using the LungPass platform: a sensitive and specific tool for identifying lower respiratory tract involvement in COVID-19
      Elena A. Lapteva, Olga N. Kharevich, Victoria V. Khatsko, Natalia A. Voronova, Maksim V. Chamko, Irina V. Bezruchko, Elena I. Katibnikova, Elena I. Loban, Mostafa M. Mouawie, Helena Binetskaya, Sergey Aleshkevich, Aleksey Karankevich, Vitaly Dubinetski, Jørgen Vestbo, Alexander G. Mathioudakis
      European Respiratory Journal 58 (6) 2101907; DOI: 10.1183/13993003.01907-2021 Published 2 December 2021
    • Open Access
      Smoke-free vehicles: impact of legislation on child smoke exposure across three countries
      Anthony A. Laverty, Filippos T. Filippidis, Jasper V. Been, Frances Campbell, Hazel Cheeseman, Nicholas S. Hopkinson
      European Respiratory Journal 58 (6) 2004600; DOI: 10.1183/13993003.04600-2020 Published 2 December 2021
    • You have accessRestricted access
      Investigating the association between ALK receptor tyrosine kinase inhibitors and pulmonary arterial hypertension: a disproportionality analysis from the WHO pharmacovigilance database
      Charles Khouri, Alex Hlavaty, Matthieu Roustit, Jean-Luc Cracowski, Marie-Camille Chaumais, Marc Humbert, David Montani
      European Respiratory Journal 58 (6) 2101576; DOI: 10.1183/13993003.01576-2021 Published 2 December 2021
  • Correspondence

    • You have accessRestricted access
      Should diffusing capacity quality control be treated like other laboratory devices?
      Jeffrey M. Haynes, Gregg L. Ruppel, David A. Kaminsky
      European Respiratory Journal 58 (6) 2102642; DOI: 10.1183/13993003.02642-2021 Published 23 December 2021
    • You have accessRestricted access
      Soluble VE-cadherin: not just a marker of endothelial permeability
      Shi Qi Li, Ying Ni Lin, Qing Yun Li
      European Respiratory Journal 58 (6) 2102241; DOI: 10.1183/13993003.02241-2021 Published 16 December 2021
    • You have accessRestricted access
      Reply: Soluble VE-cadherin: not just a marker of endothelial permeability
      Olfa Harki, Gilles Faury, Isabelle Vilgrain, Jean-Louis Pépin, Anne Briançon-Marjollet
      European Respiratory Journal 58 (6) 2102629; DOI: 10.1183/13993003.02629-2021 Published 16 December 2021
    • You have accessRestricted access
      CFTR in the regulation of pulmonary vascular tone and remodeling
      Christoph Tabeling, Martin Witzenrath, Wolfgang M. Kuebler
      European Respiratory Journal 58 (6) 2101861; DOI: 10.1183/13993003.01861-2021 Published 9 December 2021
    • You have accessRestricted access
      Room for methodological improvement in gait speed study for COPD patients
      Naoto Kuroda, Akihiro Shiroshita, Yasushi Tsujimoto
      European Respiratory Journal 58 (6) 2101445; DOI: 10.1183/13993003.01445-2021 Published 2 December 2021
    • You have accessRestricted access
      Reply to: Room for methodological improvement in gait speed study for COPD patients
      Jessica A. Walsh, Ruth E. Barker, Samantha S.C. Kon, Sarah E. Jones, Winston Banya, Claire M. Nolan, Suhani Patel, Oliver Polgar, Brigitte M. Haselden, Michael I. Polkey, Paul Cullinan, William D-C. Man
      European Respiratory Journal 58 (6) 2101796; DOI: 10.1183/13993003.01796-2021 Published 2 December 2021

Author Correction

  • You have accessRestricted access
    “Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats.” R. Dumitrascu, C. Kulcke, M. Königshoff, et al. Eur Respir J 2011; 37: 1104–1118.
    European Respiratory Journal 58 (6) 1051260; DOI: 10.1183/09031936.50126010 Published 16 December 2021
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