Table of Contents

Original Research Articles

• Clinical practice

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    Transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions: a randomised trial

    Jing Zhang, Jie-Ru Guo, Zan-Sheng Huang, Wan-Lei Fu, Xian-Li Wu, Na Wu, Wolfgang M. Kuebler, Felix J.F. Herth, Ye Fan

    European Respiratory Journal 58 (6) 2100055; DOI: 10.1183/13993003.00055-2021 Published 9 December 2021

• Cystic fibrosis

  • Open Access

    Theratyping cystic fibrosis in vitro in ALI culture and organoid models generated from patient-derived nasal epithelial conditionally reprogrammed stem cells

    Giovanni Sette, Stefania Lo Cicero, Giovanna Blaconà, Silvia Pierandrei, Sabina Maria Bruno, Valentina Salvati, Germana Castelli, Mario Falchi, Benedetta Fabrizzi, Giuseppe Cimino, Ruggero De Maria, Mauro Biffoni, Adriana Eramo, Marco Lucarelli

    European Respiratory Journal 58 (6) 2100908; DOI: 10.1183/13993003.00908-2021 Published 2 December 2021

• Interstitial lung disease

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    Serum levels of small HDL particles are negatively correlated with death or lung transplantation in an observational study of idiopathic pulmonary fibrosis

    Amisha V. Barochia, Maryann Kaler, Nargues Weir, Elizabeth M. Gordon, Debbie M. Figueroa, Xianglan Yao, Merte Lemma WoldeHanna, Maureen Sampson, Alan T. Remaley, Geraldine Grant, Scott D. Barnett, Steven D. Nathan, Stewart J. Levine

    European Respiratory Journal 58 (6) 2004053; DOI: 10.1183/13993003.04053-2020 Published 2 December 2021

• Interstitial lung disease and rare lung disease

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    Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis

    Milica Vukmirovic, Xiting Yan, Kevin F. Gibson, Mridu Gulati, Jonas C. Schupp, Giuseppe DeIuliis, Taylor S. Adams, Buqu Hu, Antun Mihaljinec, Tony N. Woolard, Heather Lynn, Nkiruka Emeagwali, Erica L. Herzog, Edward S. Chen, Alison Morris, Joseph K. Leader, Yingze Zhang, Joe G.N. Garcia, Lisa A. Maier, Ronald G. Collman, Wonder P. Drake, Michael J. Becich, Harry Hochheiser, Steven R. Wisniewski, Panayiotis V. Benos, David R. Moller, Antje Prasse, Laura L. Koth, Naftali Kaminski on behalf of the GRADS Investigators

    European Respiratory Journal 58 (6) 2002950; DOI: 10.1183/13993003.02950-2020 Published 2 December 2021

• Interstitial lung disease and COVID-19

  • Open Access

    Interstitial lung disease increases susceptibility to and severity of COVID-19

    Hyun Lee, Hayoung Choi, Bumhee Yang, Sun-Kyung Lee, Tai Sun Park, Dong Won Park, Ji-Yong Moon, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon, Sang-Heon Kim

    European Respiratory Journal 58 (6) 2004125; DOI: 10.1183/13993003.04125-2020 Published 2 December 2021

• COVID-19

  • Open Access

    Chronic respiratory diseases are predictors of severe outcome in COVID-19 hospitalised patients: a nationwide study

    Guillaume Beltramo, Jonathan Cottenet, Anne-Sophie Mariet, Marjolaine Georges, Lionel Piroth, Pascale Tubert-Bitter, Philippe Bonniaud, Catherine Quantin

    European Respiratory Journal 58 (6) 2004474; DOI: 10.1183/13993003.04474-2020 Published 9 December 2021

• Tuberculosis

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    Performance of Xpert MTB/RIF Ultra for tuberculosis diagnosis in the context of passive and active case finding

    Belén Saavedra, Edson Mambuque, Dinis Nguenha, Neide Gomes, Shilzia Munguambe, Juan Ignacio García, Santiago Izco, Sozinho Acacio, Adrià Murias-Closas, Marta Cossa, Irene Losada, Hadrián Pernas-Pardavila, Laura Oliveras, Grant Theron, Alberto L. García-Basteiro

    European Respiratory Journal 58 (6) 2100257; DOI: 10.1183/13993003.00257-2021 Published 23 December 2021

• Respiratory infections

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    Feasibility of shortening intravenous antibiotic therapy for bronchiectasis based on bacterial load: a proof-of-concept randomised controlled trial

    Pallavi Bedi, Manjit K. Cartlidge, Yang Zhang, Kim Turnbull, Samantha Donaldson, Andrea Clarke, Jane Crowe, Kadiga Campbell, Catriona Graham, Ruzanna Franguylan, Adriano G. Rossi, Adam T. Hill

    European Respiratory Journal 58 (6) 2004388; DOI: 10.1183/13993003.04388-2020 Published 16 December 2021

• Pulmonary vascular disease

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    Evolution of CT findings after anticoagulant treatment for acute pulmonary embolism in patients with and without an ultimate diagnosis of chronic thromboembolic pulmonary hypertension

    Natalia J. Braams, Gudula J.A.M. Boon, Frances S. de Man, Josien van Es, Paul L. den Exter, Lucia J.M. Kroft, Ludo F.M. Beenen, Menno V. Huisman, Esther J. Nossent, Anco Boonstra, Anton Vonk Noordegraaf, Dieuwertje Ruigrok, Frederikus A. Klok, Harm Jan Bogaard, Lilian J. Meijboom

    European Respiratory Journal 58 (6) 2100699; DOI: 10.1183/13993003.00699-2021 Published 23 December 2021
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    Role of angiopoietin-2 in venous thrombus resolution and chronic thromboembolic disease

    Lukas Hobohm, Sebastian Kölmel, Caroline Niemann, Philipp Kümpers, Valentin J. Krieg, Magdalena L. Bochenek, Alexander H. Lukasz, Yvonne Reiss, Karl-Heinz Plate, Christoph Liebetrau, Christoph B. Wiedenroth, Stefan Guth, Thomas Münzel, Gerd Hasenfuß, Philip Wenzel, Eckhard Mayer, Stavros V. Konstantinides, Katrin Schäfer, Mareike Lankeit

    European Respiratory Journal 58 (6) 2004196; DOI: 10.1183/13993003.04196-2020 Published 2 December 2021

• Lung structure and function

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    Occupational inhalant exposures and longitudinal lung function decline

    Stinna Skaaby, Esben Meulengracht Flachs, Peter Lange, Vivi Schlünssen, Jacob Louis Marott, Charlotte Brauer, Yunus Çolak, Shoaib Afzal, Børge G. Nordestgaard, Steven Sadhra, Om Kurmi, Jens Peter Ellekilde Bonde

    European Respiratory Journal 58 (6) 2004341; DOI: 10.1183/13993003.04341-2020 Published 2 December 2021

• Asthma

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    Patient characteristics, biomarkers and exacerbation risk in severe, uncontrolled asthma

    Monica Kraft, Guy Brusselle, J. Mark FitzGerald, Ian D. Pavord, Matthew Keith, Malin Fagerås, Esther Garcia Gil, Ian Hirsch, Mitchell Goldman, Gene Colice

    European Respiratory Journal 58 (6) 2100413; DOI: 10.1183/13993003.00413-2021 Published 16 December 2021
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    Socioeconomic biases in asthma control and specialist referral of possible severe asthma

    Kjell Erik Julius Håkansson, Vibeke Backer, Charlotte Suppli Ulrik

    European Respiratory Journal 58 (6) 2100741; DOI: 10.1183/13993003.00741-2021 Published 16 December 2021
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    COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE therapy

    Markus Weckmann, Thomas Bahmer, Jannie Marie Sand, Sarah Rank Rønnow, Martin Pech, Cornelis Vermeulen, Alen Faiz, Diana Julie Leeming, Morten Asser Karsdal, Lars Lunding, Brian George G. Oliver, Michael Wegmann, Gudrun Ulrich-Merzenich, Uwe R. Juergens, Jannis Duhn, Yves Laumonnier, Olga Danov, Katherina Sewald, Ulrich Zissler, Marnix Jonker, Inke König, Gesine Hansen, Erika von Mutius, Oliver Fuchs, Anna-Maria Dittrich, Bianca Schaub, Christine Happle, Klaus F. Rabe, Maarten van de Berge, Janette Kay Burgess, Matthias Volkmar Kopp the ALLIANCE Study Group as part of the German Centre for Lung Research (DZL)

    European Respiratory Journal 58 (6) 2003969; DOI: 10.1183/13993003.03969-2020 Published 9 December 2021

• COPD and asthma

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    Kidney function and obstructive lung disease: a bidirectional Mendelian randomisation study

    Sehoon Park, Soojin Lee, Yaerim Kim, Semin Cho, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim

    European Respiratory Journal 58 (6) 2100848; DOI: 10.1183/13993003.00848-2021 Published 9 December 2021

• COPD

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    Long-term air pollution and road traffic noise exposure and COPD: the Danish Nurse Cohort

    Shuo Liu, Youn-Hee Lim, Marie Pedersen, Jeanette T. Jørgensen, Heresh Amini, Thomas Cole-Hunter, Amar J. Mehta, Rina So, Laust H. Mortensen, Rudi G.J. Westendorp, Steffen Loft, Elvira V. Bräuner, Matthias Ketzel, Ole Hertel, Jørgen Brandt, Steen S. Jensen, Jesper H. Christensen, Torben Sigsgaard, Camilla Geels, Lise M. Frohn, Maja Brboric´, Jelena Radonic´, Maja Turk Sekulic, Klaus Bønnelykke, Claus Backalarz, Mette K. Simonsen, Zorana J. Andersen

    European Respiratory Journal 58 (6) 2004594; DOI: 10.1183/13993003.04594-2020 Published 2 December 2021

• Basic science and interstitial lung disease

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    Fibroblasts positive for meflin have anti-fibrotic properties in pulmonary fibrosis

    Yoshio Nakahara, Naozumi Hashimoto, Koji Sakamoto, Atsushi Enomoto, Taylor S. Adams, Toyoharu Yokoi, Norihito Omote, Sergio Poli, Akira Ando, Keiko Wakahara, Atsushi Suzuki, Masahide Inoue, Akitoshi Hara, Yasuyuki Mizutani, Kazuyoshi Imaizumi, Tsutomu Kawabe, Ivan O. Rosas, Masahide Takahashi, Naftali Kaminski, Yoshinori Hasegawa

    European Respiratory Journal 58 (6) 2003397; DOI: 10.1183/13993003.03397-2020 Published 23 December 2021

• Basic science and acute lung injury

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    AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1

    Israr Ahmad, Adam Molyvdas, Ming-Yuan Jian, Ting Zhou, Amie M. Traylor, Huachun Cui, Gang Liu, Weifeng Song, Anupam Agarwal, Tamas Jilling, Saurabh Aggarwal, Sadis Matalon

    European Respiratory Journal 58 (6) 2003694; DOI: 10.1183/13993003.03694-2020 Published 23 December 2021