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Table of Contents

01 October 2021; volume 58, issue 4

Editorials

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    Children's Bronchiectasis Education Advocacy and Research Network (Child-BEAR-Net): an ERS Clinical Research Collaboration on improving outcomes of children and adolescents with bronchiectasis
    Anne B. Chang, Jeanette Boyd, Andrew Bush, Keith Grimwood, Adam T. Hill, Zena Powell, Stephanie Yerkovich, Angela Zacharasiewicz, Ahmad Kantar on behalf of network
    European Respiratory Journal 58 (4) 2101657; DOI: 10.1183/13993003.01657-2021 Published 21 October 2021
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    3TR: a pan-European cross-disease research consortium aimed at improving personalised biological treatment of asthma and COPD
    Celeste Porsbjerg, Anke H. Maitland-van der Zee, Guy Brusselle, Giorgio Walter Canonica, Alvar Agusti, Rosa Faner, Claus F. Vogelmeier, Martijn Nawijn, Maarten van den Berge, Franca Rusconi, Charles Pilette, Valeria Ramiconi, Courtney Coleman, Rekha Chaudhuri, Kian Fan Chung, Jadwiga Wedzicha, Sejla Saglani, Marc P. Van der Schee, Liam Heaney, Arnaud Bourdin, Graham Roberts, Ratko Djukanovic, Piotr Kuna, Maciej Kupczyk, Judith Axmann, Heribert Staudinger, Graham W. Clarke, Sven Erik Dahlen, Chris Brightling
    European Respiratory Journal 58 (4) 2102168; DOI: 10.1183/13993003.02168-2021 Published 21 October 2021
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    Targeted adjuvant therapy in non-small cell lung cancer: trick or treat?
    Lizza E.L. Hendriks, Jan van Meerbeeck, Jacques Cadranel
    European Respiratory Journal 58 (4) 2101637; DOI: 10.1183/13993003.01637-2021 Published 28 October 2021
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    The search for realistic evidence on the outcomes of obstructive sleep apnoea
    Sophia Schiza, Patrick Lévy, Miguel Angel Martinez-Garcia, Jean-Louis Pepin, Anita Simonds, Winfried Randerath
    European Respiratory Journal 58 (4) 2101963; DOI: 10.1183/13993003.01963-2021 Published 7 October 2021
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    Management of acute pulmonary embolism: towards a (truly) global reach
    Stefano Barco, Luca Valerio
    European Respiratory Journal 58 (4) 2101055; DOI: 10.1183/13993003.01055-2021 Published 28 October 2021
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    Improving ethnic diversity in respiratory genomics research
    Martin D. Tobin, Abril G. Izquierdo
    European Respiratory Journal 58 (4) 2101615; DOI: 10.1183/13993003.01615-2021 Published 14 October 2021
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    Unravelling the unmet needs of patients with severe dyspnoea: a case for palliative oxygen
    Abebaw Mengistu Yohannes
    European Respiratory Journal 58 (4) 2100775; DOI: 10.1183/13993003.00775-2021 Published 7 October 2021
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    IL-6 trans-signalling: how Haemophilus surfs the NET to amplify inflammation in COPD
    Holly R. Keir, James D. Chalmers
    European Respiratory Journal 58 (4) 2102143; DOI: 10.1183/13993003.02143-2021 Published 14 October 2021
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    Understanding the impact of the lung microenvironment to enhance the therapeutic potential of mesenchymal stromal cells for acute respiratory distress syndrome
    Claire Masterson, Hector Gonzalez, John G. Laffey
    European Respiratory Journal 58 (4) 2100986; DOI: 10.1183/13993003.00986-2021 Published 14 October 2021
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    A new piece in the puzzle: the eosinophil and the development of COPD
    Nayia Petousi, Abigail Wooden, Richard E.K. Russell
    European Respiratory Journal 58 (4) 2101105; DOI: 10.1183/13993003.01105-2021 Published 7 October 2021
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    Human experimental models: seeking to enhance multiscale research in sleep apnoea
    Ramon Farré, David Gozal, Isaac Almendros
    European Respiratory Journal 58 (4) 2101169; DOI: 10.1183/13993003.01169-2021 Published 7 October 2021

Original Research Articles

  • Pulmonary vascular disease

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      Trends in risk stratification, in-hospital management and mortality of patients with acute pulmonary embolism: an analysis from the China pUlmonary thromboembolism REgistry Study (CURES)
      Zhenguo Zhai, Dingyi Wang, Jieping Lei, Yuanhua Yang, Xiaomao Xu, Yingqun Ji, Qun Yi, Hong Chen, Xiaoyun Hu, Zhihong Liu, Yimin Mao, Jie Zhang, Juhong Shi, Zhu Zhang, Sinan Wu, Qian Gao, Xincao Tao, Wanmu Xie, Jun Wan, Yunxia Zhang, Shuai Zhang, Kaiyuan Zhen, Zhonghe Zhang, Baomin Fang, Chen Wang on behalf of the China pUlmonary thromboembolism REgistry Study (CURES) investigators
      European Respiratory Journal 58 (4) 2002963; DOI: 10.1183/13993003.02963-2020 Published 28 October 2021
  • Tuberculosis

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      Active case-finding of tuberculosis in general populations and at-risk groups: a systematic review and meta-analysis
      Anders Solitander Bohlbro, Victor Schwartz Hvingelby, Frauke Rudolf, Christian Wejse, Cecilie Blenstrup Patsche
      European Respiratory Journal 58 (4) 2100090; DOI: 10.1183/13993003.00090-2021 Published 21 October 2021
  • Genetics and lung function

    • Open Access
      A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic aetiology with obesity
      Zhaozhong Zhu, Jiachen Li, Jiahui Si, Baoshan Ma, Huwenbo Shi, Jun Lv, Weihua Cao, Yu Guo, Iona Y. Millwood, Robin G. Walters, Kuang Lin, Ling Yang, Yiping Chen, Huaidong Du, Bo Yu, Kohei Hasegawa, Carlos A. Camargo Jr, Miriam F. Moffatt, William O.C. Cookson, Junshi Chen, Zhengming Chen, Liming Li, Canqing Yu, Liming Liang
      European Respiratory Journal 58 (4) 2100199; DOI: 10.1183/13993003.00199-2021 Published 14 October 2021
  • Dyspnoea

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      Perspectives on palliative oxygen for breathlessness: systematic review and meta-synthesis
      Slavica Kochovska, Diana H. Ferreira, Maja V. Garcia, Jane L. Phillips, David C. Currow
      European Respiratory Journal 58 (4) 2004613; DOI: 10.1183/13993003.04613-2020 Published 7 October 2021
  • Asthma

    • Open Access
      Effect of exacerbation history on clinical response to dupilumab in moderate-to-severe uncontrolled asthma
      Jonathan Corren, Constance H. Katelaris, Mario Castro, Jorge F. Maspero, Linda B. Ford, David M.G. Halpin, Megan S. Rice, Amr Radwan, Yamo Deniz, Paul J. Rowe, Ariel Teper, Michel Djandji
      European Respiratory Journal 58 (4) 2004498; DOI: 10.1183/13993003.04498-2020 Published 28 October 2021
  • Paediatrics and asthma

    • Open Access
      Dietary intake of vitamin A, lung function and incident asthma in childhood
      Mohammad Talaei, David A. Hughes, Osama Mahmoud, Pauline M. Emmett, Raquel Granell, Stefano Guerra, Seif O. Shaheen
      European Respiratory Journal 58 (4) 2004407; DOI: 10.1183/13993003.04407-2020 Published 28 October 2021
  • Paediatrics

    • Open Access
      Prenatal and prepubertal exposures to tobacco smoke in men may cause lower lung function in future offspring: a three-generation study using a causal modelling approach
      Simone Accordini, Lucia Calciano, Ane Johannessen, Bryndis Benediktsdóttir, Randi Jacobsen Bertelsen, Lennart Bråbäck, Shyamali C. Dharmage, Bertil Forsberg, Francisco Gómez Real, John W. Holloway, Mathias Holm, Christer Janson, Nils O. Jõgi, Rain Jõgi, Andrei Malinovschi, Alessandro Marcon, Jesús Martínez-Moratalla Rovira, José Luis Sánchez-Ramos, Vivi Schlünssen, Kjell Torén, Deborah Jarvis, Cecilie Svanes
      European Respiratory Journal 58 (4) 2002791; DOI: 10.1183/13993003.02791-2020 Published 21 October 2021
  • Paediatrics and infection

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      The early use of Antibiotics for at Risk CHildren with InfluEnza-like illness (ARCHIE): a double-blind randomised placebo-controlled trial
      Kay Wang, Malcolm G. Semple, Michael Moore, Alastair D. Hay, Sharon Tonner, Ushma Galal, Jenna Grabey, Tricia Carver, Rafael Perera, Ly-Mee Yu, Jill Mollison, Paul Little, Andrew Farmer, Christopher C. Butler, Anthony Harnden
      European Respiratory Journal 58 (4) 2002819; DOI: 10.1183/13993003.02819-2020 Published 7 October 2021
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      The risk of community-acquired pneumonia in children using gastric acid suppressants
      Linda J.T.M. van der Sande, Quirijn Jöbsis, Michiel A.G.E. Bannier, Ewoudt M.W. van de Garde, Jan J.M. Coremans, Frank de Vries, Edward Dompeling, Johanna H.M. Driessen
      European Respiratory Journal 58 (4) 2003229; DOI: 10.1183/13993003.03229-2020 Published 7 October 2021
  • Basic science and infection

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      Multi-omics links IL-6 trans-signalling with neutrophil extracellular trap formation and Haemophilus infection in COPD
      Sofia Winslow, Lina Odqvist, Sarah Diver, Rebecca Riise, Suado Abdillahi, Cecilia Wingren, Helena Lindmark, Annika Wellner, Sofia Lundin, Linda Yrlid, Elisabeth Ax, Ratko Djukanovic, Sriram Sridhar, Andrew Higham, Dave Singh, Thomas Southworth, Christopher E. Brightling, Henric K. Olsson, Zala Jevnikar
      European Respiratory Journal 58 (4) 2003312; DOI: 10.1183/13993003.03312-2020 Published 14 October 2021
  • Basic science and lung transplant

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      Association between the renin–angiotensin system and chronic lung allograft dysfunction
      Gregory Berra, Sofia Farkona, Zahraa Mohammed-Ali, Max Kotlyar, Liran Levy, Sergi Clotet-Freixas, Phillip Ly, Benjamin Renaud-Picard, Guan Zehong, Tina Daigneault, Allen Duong, Ihor Batruch, Igor Jurisica, Ana Konvalinka, Tereza Martinu
      European Respiratory Journal 58 (4) 2002975; DOI: 10.1183/13993003.02975-2020 Published 21 October 2021
  • Basic science

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      Healthy versus inflamed lung environments differentially affect mesenchymal stromal cells
      Sara Rolandsson Enes, Thomas H. Hampton, Jayita Barua, David H. McKenna, Claudia C. dos Santos, Eyal Amiel, Alix Ashare, Kathleen D. Liu, Anna D. Krasnodembskaya, Karen English, Bruce A. Stanton, Patricia R.M. Rocco, Michael A. Matthay, Daniel J. Weiss
      European Respiratory Journal 58 (4) 2004149; DOI: 10.1183/13993003.04149-2020 Published 14 October 2021
    • Open Access
      Higher throughput drug screening for rare respiratory diseases: readthrough therapy in primary ciliary dyskinesia
      Dani Do Hyang Lee, Daniela Cardinale, Ersilia Nigro, Colin R. Butler, Andrew Rutman, Mahmoud R. Fassad, Robert A. Hirst, Dale Moulding, Alexander Agrotis, Elisabeth Forsythe, Daniel Peckham, Evie Robson, Claire M. Smith, Satyanarayana Somavarapu, Philip L. Beales, Stephen L. Hart, Sam M. Janes, Hannah M. Mitchison, Robin Ketteler, Robert E. Hynds, Christopher O'Callaghan
      European Respiratory Journal 58 (4) 2000455; DOI: 10.1183/13993003.00455-2020 Published 14 October 2021
  • COPD

    • You have accessRestricted access
      Blood eosinophil counts and the development of obstructive lung disease: the Kangbuk Samsung Health Study
      Hye Yun Park, Yoosoo Chang, Danbee Kang, Yun Soo Hong, Di Zhao, Jiin Ahn, Sun Hye Shin, Dave Singh, Eliseo Guallar, Juhee Cho, Seungho Ryu
      European Respiratory Journal 58 (4) 2003823; DOI: 10.1183/13993003.03823-2020 Published 7 October 2021
  • Sleep

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      VE-cadherin cleavage in sleep apnoea: new insights into intermittent hypoxia-related endothelial permeability
      Olfa Harki, Renaud Tamisier, Jean-Louis Pépin, Sébastien Bailly, Anissa Mahmani, Brigitte Gonthier, Aude Salomon, Isabelle Vilgrain, Gilles Faury, Anne Briançon-Marjollet
      European Respiratory Journal 58 (4) 2004518; DOI: 10.1183/13993003.04518-2020 Published 7 October 2021
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      Impact of obstructive sleep apnoea and intermittent hypoxia on blood rheology: a translational study
      Xavier Waltz, Andrew E. Beaudin, Elise Belaidi, Jill Raneri, Jean-Louis Pépin, Vincent Pialoux, Patrick J. Hanly, Samuel Verges, Marc J. Poulin
      European Respiratory Journal 58 (4) 2100352; DOI: 10.1183/13993003.00352-2021 Published 7 October 2021

Back to Basics

  • Open Access
    Neurohormonal modulation in pulmonary arterial hypertension
    Eva L. Peters, Harm Jan Bogaard, Anton Vonk Noordegraaf, Frances S. de Man
    European Respiratory Journal 58 (4) 2004633; DOI: 10.1183/13993003.04633-2020 Published 28 October 2021

Review

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    Referral criteria to palliative care for patients with respiratory disease: a systematic review
    Jennifer Philip, Anna Collins, Natasha Smallwood, Yuchieh Kathryn Chang, Li Mo, Ian A. Yang, Tamera Corte, Christine F. McDonald, David Hui
    European Respiratory Journal 58 (4) 2004307; DOI: 10.1183/13993003.04307-2020 Published 21 October 2021

Agora

  • Research letters

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      Mental health indicators and lung function following a large oil spill
      Kaitlyn G. Lawrence, Emily J. Werder, Richard K. Kwok, Lawrence S. Engel, Dale P. Sandler
      European Respiratory Journal 58 (4) 2100712; DOI: 10.1183/13993003.00712-2021 Published 28 October 2021
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      Vitamin D supplementation, lung function and asthma control in children with asthma and low vitamin D levels
      Yueh-Ying Han, Erick Forno, Leonard B. Bacharier, Wanda Phipatanakul, Theresa W. Guilbert, Michael D. Cabana, Kristie Ross, Joshua Blatter, Franziska J. Rosser, Sandy Durrani, James Luther, Stephen R. Wisniewski, Juan C. Celedón
      European Respiratory Journal 58 (4) 2100989; DOI: 10.1183/13993003.00989-2021 Published 28 October 2021
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      Effect of surgical mask on exercise capacity in COPD: a randomised crossover trial
      Kuniaki Hirai, Akihiko Tanaka, Hiroki Sato, Yoko Sato, Yoshitaka Uchida, Eisuke Inoue, Hironori Sagara
      European Respiratory Journal 58 (4) 2102041; DOI: 10.1183/13993003.02041-2021 Published 28 October 2021
    • Open Access
      Autoimmunity to annexin A2 predicts mortality among hospitalised COVID-19 patients
      Marisol Zuniga, Claudia Gomes, Steven E. Carsons, Michael T. Bender, Paolo Cotzia, Qing Robert Miao, David C. Lee, Ana Rodriguez
      European Respiratory Journal 58 (4) 2100918; DOI: 10.1183/13993003.00918-2021 Published 21 October 2021
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      Digital-Rapid On-site Examination in Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (DEBUT): a proof of concept study for the application of artificial intelligence in the bronchoscopy suite
      Shahir Asfahan, Poonam Elhence, Naveen Dutt, Ram Niwas Jalandra, Nishant Kumar Chauhan
      European Respiratory Journal 58 (4) 2100915; DOI: 10.1183/13993003.00915-2021 Published 14 October 2021
    • Open Access
      Standard pleural interventions are not high-risk aerosol generating procedures
      David T. Arnold, Florence K.A. Gregson, Sadiyah Sheikh, Fergus W. Hamilton, Hugh Welch, Alexandra Dipper, George W. Nava, AERATOR group, James W. Dodd, Amelia O. Clive, Bryan R. Bzdek, Jonathan P. Reid, Nick A. Maskell
      European Respiratory Journal 58 (4) 2101064; DOI: 10.1183/13993003.01064-2021 Published 14 October 2021
    • Open Access
      A phase 2 multiple ascending dose study of the inhaled pan-JAK inhibitor nezulcitinib (TD-0903) in severe COVID-19
      Dave Singh, Maxim Bogus, Valentyn Moskalenko, Robert Lord, Edmund J. Moran, Glenn D. Crater, David L. Bourdet, Nathan D. Pfeifer, Jacky Woo, Elad Kaufman, David A. Lombardi, Emily Y. Weng, Tuan Nguyen, Ashley Woodcock, Brett Haumann, Rajeev Saggar
      European Respiratory Journal 58 (4) 2100673; DOI: 10.1183/13993003.00673-2021 Published 14 October 2021
    • Open Access
      Impact of baseline patient characteristics on dupilumab efficacy in type 2 asthma
      William W. Busse, Pierluigi Paggiaro, Xavier Muñoz, Thomas B. Casale, Mario Castro, G. Walter Canonica, Jo A. Douglass, Yuji Tohda, Nadia Daizadeh, Benjamin Ortiz, Nami Pandit-Abid
      European Respiratory Journal 58 (4) 2004605; DOI: 10.1183/13993003.04605-2020 Published 7 October 2021
    • Open Access
      Steroid use in elderly critically ill COVID-19 patients
      Christian Jung, Bernhard Wernly, Jesper Fjølner, Raphael Romano Bruno, David Dudzinski, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Georg Wolff, Malte Kelm, Michael Beil, Sviri Sigal, Peter Vernon van Heerden, Wojciech Szczeklik, Miroslaw Czuczwar, Muhammed Elhadi, Michael Joannidis, Sandra Oeyen, Tilemachos Zafeiridis, Brian Marsh, Finn H. Andersen, Rui Moreno, Maurizio Cecconi, Susannah Leaver, Ariane Boumendil, Dylan W. De Lange, Bertrand Guidet, Hans Flaatten and the COVIP study group
      European Respiratory Journal 58 (4) 2100979; DOI: 10.1183/13993003.00979-2021 Published 7 October 2021
    • You have accessRestricted access
      Measurement of hypoxia in the lung in idiopathic pulmonary fibrosis: an F-MISO PET/CT study
      Joanna C. Porter, Thida Win, Kjell Erlandsson, Francesco Fraioli, Alaleh Rashidnasab, Beverley Holman, Balaji Ganeshan, Nicholas J. Screaton, Toby M. Maher, Raymond Endozo, John Hoath, Robert I. Shortman, Elise Emond, Kris Thielemans, Brian F. Hutton, Pauline T. Lukey, Franklin Aigbirhio, Saif Khan, Manuel Rodriguez-Justo, Ashley M. Groves
      European Respiratory Journal 58 (4) 2004584; DOI: 10.1183/13993003.04584-2020 Published 7 October 2021
  • Correspondence

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      Air pollution and poverty: a deadly combination in idiopathic pulmonary fibrosis?
      Lucile Sesé, Isabella Annesi-Maesano, Catherine Cavalin, Hilario Nunes
      European Respiratory Journal 58 (4) 2101714; DOI: 10.1183/13993003.01714-2021 Published 21 October 2021
    • You have accessRestricted access
      The Cochrane review of electronic cigarettes for smoking cessation: remaining focused on the evidence
      Caitlin Notley, Ailsa R. Butler, Nicola Lindson, Chris Bullen, Annika Theodoulou, Rachna Begh, Hayden McRobbie, Peter Hajek, Nancy Rigotti, Jamie Hartman-Boyce
      European Respiratory Journal 58 (4) 2102117; DOI: 10.1183/13993003.02117-2021 Published 7 October 2021
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