European Respiratory Journal: 58 (4)

01 October 2021; volume 58, issue 4

Editorials

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Children's Bronchiectasis Education Advocacy and Research Network (Child-BEAR-Net): an ERS Clinical Research Collaboration on improving outcomes of children and adolescents with bronchiectasis
Anne B. Chang, Jeanette Boyd, Andrew Bush, Keith Grimwood, Adam T. Hill, Zena Powell, Stephanie Yerkovich, Angela Zacharasiewicz, Ahmad Kantar on behalf of network

European Respiratory Journal 58 (4) 2101657; DOI: 10.1183/13993003.01657-2021 Published 21 October 2021
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3TR: a pan-European cross-disease research consortium aimed at improving personalised biological treatment of asthma and COPD
Celeste Porsbjerg, Anke H. Maitland-van der Zee, Guy Brusselle, Giorgio Walter Canonica, Alvar Agusti, Rosa Faner, Claus F. Vogelmeier, Martijn Nawijn, Maarten van den Berge, Franca Rusconi, Charles Pilette, Valeria Ramiconi, Courtney Coleman, Rekha Chaudhuri, Kian Fan Chung, Jadwiga Wedzicha, Sejla Saglani, Marc P. Van der Schee, Liam Heaney, Arnaud Bourdin, Graham Roberts, Ratko Djukanovic, Piotr Kuna, Maciej Kupczyk, Judith Axmann, Heribert Staudinger, Graham W. Clarke, Sven Erik Dahlen, Chris Brightling

European Respiratory Journal 58 (4) 2102168; DOI: 10.1183/13993003.02168-2021 Published 21 October 2021
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The search for realistic evidence on the outcomes of obstructive sleep apnoea
Sophia Schiza, Patrick Lévy, Miguel Angel Martinez-Garcia, Jean-Louis Pepin, Anita Simonds, Winfried Randerath

European Respiratory Journal 58 (4) 2101963; DOI: 10.1183/13993003.01963-2021 Published 7 October 2021
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Improving ethnic diversity in respiratory genomics research
Martin D. Tobin, Abril G. Izquierdo

European Respiratory Journal 58 (4) 2101615; DOI: 10.1183/13993003.01615-2021 Published 14 October 2021
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Unravelling the unmet needs of patients with severe dyspnoea: a case for palliative oxygen
Abebaw Mengistu Yohannes

European Respiratory Journal 58 (4) 2100775; DOI: 10.1183/13993003.00775-2021 Published 7 October 2021
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IL-6 trans-signalling: how Haemophilus surfs the NET to amplify inflammation in COPD
Holly R. Keir, James D. Chalmers

European Respiratory Journal 58 (4) 2102143; DOI: 10.1183/13993003.02143-2021 Published 14 October 2021
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Understanding the impact of the lung microenvironment to enhance the therapeutic potential of mesenchymal stromal cells for acute respiratory distress syndrome
Claire Masterson, Hector Gonzalez, John G. Laffey

European Respiratory Journal 58 (4) 2100986; DOI: 10.1183/13993003.00986-2021 Published 14 October 2021
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A new piece in the puzzle: the eosinophil and the development of COPD
Nayia Petousi, Abigail Wooden, Richard E.K. Russell

European Respiratory Journal 58 (4) 2101105; DOI: 10.1183/13993003.01105-2021 Published 7 October 2021
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Human experimental models: seeking to enhance multiscale research in sleep apnoea
Ramon Farré, David Gozal, Isaac Almendros

European Respiratory Journal 58 (4) 2101169; DOI: 10.1183/13993003.01169-2021 Published 7 October 2021

Original Research Articles

Tuberculosis
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  Active case-finding of tuberculosis in general populations and at-risk groups: a systematic review and meta-analysis
  Anders Solitander Bohlbro, Victor Schwartz Hvingelby, Frauke Rudolf, Christian Wejse, Cecilie Blenstrup Patsche
  
  European Respiratory Journal 58 (4) 2100090; DOI: 10.1183/13993003.00090-2021 Published 21 October 2021
Genetics and lung function
- Open Access
  A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic aetiology with obesity
  Zhaozhong Zhu, Jiachen Li, Jiahui Si, Baoshan Ma, Huwenbo Shi, Jun Lv, Weihua Cao, Yu Guo, Iona Y. Millwood, Robin G. Walters, Kuang Lin, Ling Yang, Yiping Chen, Huaidong Du, Bo Yu, Kohei Hasegawa, Carlos A. Camargo Jr, Miriam F. Moffatt, William O.C. Cookson, Junshi Chen, Zhengming Chen, Liming Li, Canqing Yu, Liming Liang
  
  European Respiratory Journal 58 (4) 2100199; DOI: 10.1183/13993003.00199-2021 Published 14 October 2021
Dyspnoea
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  Perspectives on palliative oxygen for breathlessness: systematic review and meta-synthesis
  Slavica Kochovska, Diana H. Ferreira, Maja V. Garcia, Jane L. Phillips, David C. Currow
  
  European Respiratory Journal 58 (4) 2004613; DOI: 10.1183/13993003.04613-2020 Published 7 October 2021
Paediatrics
- Open Access
  Prenatal and prepubertal exposures to tobacco smoke in men may cause lower lung function in future offspring: a three-generation study using a causal modelling approach
  Simone Accordini, Lucia Calciano, Ane Johannessen, Bryndis Benediktsdóttir, Randi Jacobsen Bertelsen, Lennart Bråbäck, Shyamali C. Dharmage, Bertil Forsberg, Francisco Gómez Real, John W. Holloway, Mathias Holm, Christer Janson, Nils O. Jõgi, Rain Jõgi, Andrei Malinovschi, Alessandro Marcon, Jesús Martínez-Moratalla Rovira, José Luis Sánchez-Ramos, Vivi Schlünssen, Kjell Torén, Deborah Jarvis, Cecilie Svanes
  
  European Respiratory Journal 58 (4) 2002791; DOI: 10.1183/13993003.02791-2020 Published 21 October 2021
Paediatrics and infection
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  The early use of Antibiotics for at Risk CHildren with InfluEnza-like illness (ARCHIE): a double-blind randomised placebo-controlled trial
  Kay Wang, Malcolm G. Semple, Michael Moore, Alastair D. Hay, Sharon Tonner, Ushma Galal, Jenna Grabey, Tricia Carver, Rafael Perera, Ly-Mee Yu, Jill Mollison, Paul Little, Andrew Farmer, Christopher C. Butler, Anthony Harnden
  
  European Respiratory Journal 58 (4) 2002819; DOI: 10.1183/13993003.02819-2020 Published 7 October 2021
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  The risk of community-acquired pneumonia in children using gastric acid suppressants
  Linda J.T.M. van der Sande, Quirijn Jöbsis, Michiel A.G.E. Bannier, Ewoudt M.W. van de Garde, Jan J.M. Coremans, Frank de Vries, Edward Dompeling, Johanna H.M. Driessen
  
  European Respiratory Journal 58 (4) 2003229; DOI: 10.1183/13993003.03229-2020 Published 7 October 2021
Basic science and infection
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  Multi-omics links IL-6 trans-signalling with neutrophil extracellular trap formation and Haemophilus infection in COPD
  Sofia Winslow, Lina Odqvist, Sarah Diver, Rebecca Riise, Suado Abdillahi, Cecilia Wingren, Helena Lindmark, Annika Wellner, Sofia Lundin, Linda Yrlid, Elisabeth Ax, Ratko Djukanovic, Sriram Sridhar, Andrew Higham, Dave Singh, Thomas Southworth, Christopher E. Brightling, Henric K. Olsson, Zala Jevnikar
  
  European Respiratory Journal 58 (4) 2003312; DOI: 10.1183/13993003.03312-2020 Published 14 October 2021
Basic science and lung transplant
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  Association between the renin–angiotensin system and chronic lung allograft dysfunction
  Gregory Berra, Sofia Farkona, Zahraa Mohammed-Ali, Max Kotlyar, Liran Levy, Sergi Clotet-Freixas, Phillip Ly, Benjamin Renaud-Picard, Guan Zehong, Tina Daigneault, Allen Duong, Ihor Batruch, Igor Jurisica, Ana Konvalinka, Tereza Martinu
  
  European Respiratory Journal 58 (4) 2002975; DOI: 10.1183/13993003.02975-2020 Published 21 October 2021
Basic science
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  Healthy versus inflamed lung environments differentially affect mesenchymal stromal cells
  Sara Rolandsson Enes, Thomas H. Hampton, Jayita Barua, David H. McKenna, Claudia C. dos Santos, Eyal Amiel, Alix Ashare, Kathleen D. Liu, Anna D. Krasnodembskaya, Karen English, Bruce A. Stanton, Patricia R.M. Rocco, Michael A. Matthay, Daniel J. Weiss
  
  European Respiratory Journal 58 (4) 2004149; DOI: 10.1183/13993003.04149-2020 Published 14 October 2021
- Open Access
  Higher throughput drug screening for rare respiratory diseases: readthrough therapy in primary ciliary dyskinesia
  Dani Do Hyang Lee, Daniela Cardinale, Ersilia Nigro, Colin R. Butler, Andrew Rutman, Mahmoud R. Fassad, Robert A. Hirst, Dale Moulding, Alexander Agrotis, Elisabeth Forsythe, Daniel Peckham, Evie Robson, Claire M. Smith, Satyanarayana Somavarapu, Philip L. Beales, Stephen L. Hart, Sam M. Janes, Hannah M. Mitchison, Robin Ketteler, Robert E. Hynds, Christopher O'Callaghan
  
  European Respiratory Journal 58 (4) 2000455; DOI: 10.1183/13993003.00455-2020 Published 14 October 2021
COPD
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  Blood eosinophil counts and the development of obstructive lung disease: the Kangbuk Samsung Health Study
  Hye Yun Park, Yoosoo Chang, Danbee Kang, Yun Soo Hong, Di Zhao, Jiin Ahn, Sun Hye Shin, Dave Singh, Eliseo Guallar, Juhee Cho, Seungho Ryu
  
  European Respiratory Journal 58 (4) 2003823; DOI: 10.1183/13993003.03823-2020 Published 7 October 2021
Sleep
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  VE-cadherin cleavage in sleep apnoea: new insights into intermittent hypoxia-related endothelial permeability
  Olfa Harki, Renaud Tamisier, Jean-Louis Pépin, Sébastien Bailly, Anissa Mahmani, Brigitte Gonthier, Aude Salomon, Isabelle Vilgrain, Gilles Faury, Anne Briançon-Marjollet
  
  European Respiratory Journal 58 (4) 2004518; DOI: 10.1183/13993003.04518-2020 Published 7 October 2021
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  Impact of obstructive sleep apnoea and intermittent hypoxia on blood rheology: a translational study
  Xavier Waltz, Andrew E. Beaudin, Elise Belaidi, Jill Raneri, Jean-Louis Pépin, Vincent Pialoux, Patrick J. Hanly, Samuel Verges, Marc J. Poulin
  
  European Respiratory Journal 58 (4) 2100352; DOI: 10.1183/13993003.00352-2021 Published 7 October 2021

Review

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Referral criteria to palliative care for patients with respiratory disease: a systematic review
Jennifer Philip, Anna Collins, Natasha Smallwood, Yuchieh Kathryn Chang, Li Mo, Ian A. Yang, Tamera Corte, Christine F. McDonald, David Hui

European Respiratory Journal 58 (4) 2004307; DOI: 10.1183/13993003.04307-2020 Published 21 October 2021

Agora

Research letters
- Open Access
  Autoimmunity to annexin A2 predicts mortality among hospitalised COVID-19 patients
  Marisol Zuniga, Claudia Gomes, Steven E. Carsons, Michael T. Bender, Paolo Cotzia, Qing Robert Miao, David C. Lee, Ana Rodriguez
  
  European Respiratory Journal 58 (4) 2100918; DOI: 10.1183/13993003.00918-2021 Published 21 October 2021
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  Digital-Rapid On-site Examination in Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (DEBUT): a proof of concept study for the application of artificial intelligence in the bronchoscopy suite
  Shahir Asfahan, Poonam Elhence, Naveen Dutt, Ram Niwas Jalandra, Nishant Kumar Chauhan
  
  European Respiratory Journal 58 (4) 2100915; DOI: 10.1183/13993003.00915-2021 Published 14 October 2021
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  Standard pleural interventions are not high-risk aerosol generating procedures
  David T. Arnold, Florence K.A. Gregson, Sadiyah Sheikh, Fergus W. Hamilton, Hugh Welch, Alexandra Dipper, George W. Nava, James W. Dodd, Amelia O. Clive, Bryan R. Bzdek, Jonathan P. Reid, Nick A. Maskell
  
  European Respiratory Journal 58 (4) 2101064; DOI: 10.1183/13993003.01064-2021 Published 14 October 2021
- Open Access
  A phase 2 multiple ascending dose study of the inhaled pan-JAK inhibitor nezulcitinib (TD-0903) in severe COVID-19
  Dave Singh, Maxim Bogus, Valentyn Moskalenko, Robert Lord, Edmund J. Moran, Glenn D. Crater, David L. Bourdet, Nathan D. Pfeifer, Jacky Woo, Elad Kaufman, David A. Lombardi, Emily Y. Weng, Tuan Nguyen, Ashley Woodcock, Brett Haumann, Rajeev Saggar
  
  European Respiratory Journal 58 (4) 2100673; DOI: 10.1183/13993003.00673-2021 Published 14 October 2021
- Open Access
  Impact of baseline patient characteristics on dupilumab efficacy in type 2 asthma
  William W. Busse, Pierluigi Paggiaro, Xavier Muñoz, Thomas B. Casale, Mario Castro, G. Walter Canonica, Jo A. Douglass, Yuji Tohda, Nadia Daizadeh, Benjamin Ortiz, Nami Pandit-Abid
  
  European Respiratory Journal 58 (4) 2004605; DOI: 10.1183/13993003.04605-2020 Published 7 October 2021
- Open Access
  Steroid use in elderly critically ill COVID-19 patients
  Christian Jung, Bernhard Wernly, Jesper Fjølner, Raphael Romano Bruno, David Dudzinski, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Georg Wolff, Malte Kelm, Michael Beil, Sviri Sigal, Peter Vernon van Heerden, Wojciech Szczeklik, Miroslaw Czuczwar, Muhammed Elhadi, Michael Joannidis, Sandra Oeyen, Tilemachos Zafeiridis, Brian Marsh, Finn H. Andersen, Rui Moreno, Maurizio Cecconi, Susannah Leaver, Ariane Boumendil, Dylan W. De Lange, Bertrand Guidet, Hans Flaatten and the COVIP study group
  
  European Respiratory Journal 58 (4) 2100979; DOI: 10.1183/13993003.00979-2021 Published 7 October 2021
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  Measurement of hypoxia in the lung in idiopathic pulmonary fibrosis: an F-MISO PET/CT study
  Joanna C. Porter, Thida Win, Kjell Erlandsson, Francesco Fraioli, Alaleh Rashidnasab, Beverley Holman, Balaji Ganeshan, Nicholas J. Screaton, Toby M. Maher, Raymond Endozo, John Hoath, Robert I. Shortman, Elise Emond, Kris Thielemans, Brian F. Hutton, Pauline T. Lukey, Franklin Aigbirhio, Saif Khan, Manuel Rodriguez-Justo, Ashley M. Groves
  
  European Respiratory Journal 58 (4) 2004584; DOI: 10.1183/13993003.04584-2020 Published 7 October 2021
Correspondence
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  Air pollution and poverty: a deadly combination in idiopathic pulmonary fibrosis?
  Lucile Sesé, Isabella Annesi-Maesano, Catherine Cavalin, Hilario Nunes
  
  European Respiratory Journal 58 (4) 2101714; DOI: 10.1183/13993003.01714-2021 Published 21 October 2021
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  The Cochrane review of electronic cigarettes for smoking cessation: remaining focused on the evidence
  Caitlin Notley, Ailsa R. Butler, Nicola Lindson, Chris Bullen, Annika Theodoulou, Rachna Begh, Hayden McRobbie, Peter Hajek, Nancy Rigotti, Jamie Hartman-Boyce
  
  European Respiratory Journal 58 (4) 2102117; DOI: 10.1183/13993003.02117-2021 Published 7 October 2021

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Table of Contents

Editorials

Original Research Articles

Tuberculosis

Genetics and lung function

Dyspnoea

Paediatrics

Paediatrics and infection

Basic science and infection

Basic science and lung transplant

Basic science

COPD

Sleep

Review

Agora

Research letters

Correspondence

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