Table of Contents

Original Research Articles

• Pulmonary vascular disease

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    Trends in risk stratification, in-hospital management and mortality of patients with acute pulmonary embolism: an analysis from the China pUlmonary thromboembolism REgistry Study (CURES)

    Zhenguo Zhai, Dingyi Wang, Jieping Lei, Yuanhua Yang, Xiaomao Xu, Yingqun Ji, Qun Yi, Hong Chen, Xiaoyun Hu, Zhihong Liu, Yimin Mao, Jie Zhang, Juhong Shi, Zhu Zhang, Sinan Wu, Qian Gao, Xincao Tao, Wanmu Xie, Jun Wan, Yunxia Zhang, Shuai Zhang, Kaiyuan Zhen, Zhonghe Zhang, Baomin Fang, Chen Wang on behalf of the China pUlmonary thromboembolism REgistry Study (CURES) investigators

    European Respiratory Journal 58 (4) 2002963; DOI: 10.1183/13993003.02963-2020 Published 28 October 2021

• Tuberculosis

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    Active case-finding of tuberculosis in general populations and at-risk groups: a systematic review and meta-analysis

    Anders Solitander Bohlbro, Victor Schwartz Hvingelby, Frauke Rudolf, Christian Wejse, Cecilie Blenstrup Patsche

    European Respiratory Journal 58 (4) 2100090; DOI: 10.1183/13993003.00090-2021 Published 21 October 2021

• Genetics and lung function

  • Open Access

    A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic aetiology with obesity

    Zhaozhong Zhu, Jiachen Li, Jiahui Si, Baoshan Ma, Huwenbo Shi, Jun Lv, Weihua Cao, Yu Guo, Iona Y. Millwood, Robin G. Walters, Kuang Lin, Ling Yang, Yiping Chen, Huaidong Du, Bo Yu, Kohei Hasegawa, Carlos A. Camargo Jr, Miriam F. Moffatt, William O.C. Cookson, Junshi Chen, Zhengming Chen, Liming Li, Canqing Yu, Liming Liang

    European Respiratory Journal 58 (4) 2100199; DOI: 10.1183/13993003.00199-2021 Published 14 October 2021

• Dyspnoea

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    Perspectives on palliative oxygen for breathlessness: systematic review and meta-synthesis

    Slavica Kochovska, Diana H. Ferreira, Maja V. Garcia, Jane L. Phillips, David C. Currow

    European Respiratory Journal 58 (4) 2004613; DOI: 10.1183/13993003.04613-2020 Published 7 October 2021

• Asthma

  • Open Access

    Effect of exacerbation history on clinical response to dupilumab in moderate-to-severe uncontrolled asthma

    Jonathan Corren, Constance H. Katelaris, Mario Castro, Jorge F. Maspero, Linda B. Ford, David M.G. Halpin, Megan S. Rice, Amr Radwan, Yamo Deniz, Paul J. Rowe, Ariel Teper, Michel Djandji

    European Respiratory Journal 58 (4) 2004498; DOI: 10.1183/13993003.04498-2020 Published 28 October 2021

• Paediatrics and asthma

  • Open Access

    Dietary intake of vitamin A, lung function and incident asthma in childhood

    Mohammad Talaei, David A. Hughes, Osama Mahmoud, Pauline M. Emmett, Raquel Granell, Stefano Guerra, Seif O. Shaheen

    European Respiratory Journal 58 (4) 2004407; DOI: 10.1183/13993003.04407-2020 Published 28 October 2021

• Paediatrics

  • Open Access

    Prenatal and prepubertal exposures to tobacco smoke in men may cause lower lung function in future offspring: a three-generation study using a causal modelling approach

    Simone Accordini, Lucia Calciano, Ane Johannessen, Bryndis Benediktsdóttir, Randi Jacobsen Bertelsen, Lennart Bråbäck, Shyamali C. Dharmage, Bertil Forsberg, Francisco Gómez Real, John W. Holloway, Mathias Holm, Christer Janson, Nils O. Jõgi, Rain Jõgi, Andrei Malinovschi, Alessandro Marcon, Jesús Martínez-Moratalla Rovira, José Luis Sánchez-Ramos, Vivi Schlünssen, Kjell Torén, Deborah Jarvis, Cecilie Svanes

    European Respiratory Journal 58 (4) 2002791; DOI: 10.1183/13993003.02791-2020 Published 21 October 2021

• Paediatrics and infection

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    The early use of Antibiotics for at Risk CHildren with InfluEnza-like illness (ARCHIE): a double-blind randomised placebo-controlled trial

    Kay Wang, Malcolm G. Semple, Michael Moore, Alastair D. Hay, Sharon Tonner, Ushma Galal, Jenna Grabey, Tricia Carver, Rafael Perera, Ly-Mee Yu, Jill Mollison, Paul Little, Andrew Farmer, Christopher C. Butler, Anthony Harnden

    European Respiratory Journal 58 (4) 2002819; DOI: 10.1183/13993003.02819-2020 Published 7 October 2021
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    The risk of community-acquired pneumonia in children using gastric acid suppressants

    Linda J.T.M. van der Sande, Quirijn Jöbsis, Michiel A.G.E. Bannier, Ewoudt M.W. van de Garde, Jan J.M. Coremans, Frank de Vries, Edward Dompeling, Johanna H.M. Driessen

    European Respiratory Journal 58 (4) 2003229; DOI: 10.1183/13993003.03229-2020 Published 7 October 2021

• Basic science and infection

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    Multi-omics links IL-6 trans-signalling with neutrophil extracellular trap formation and Haemophilus infection in COPD

    Sofia Winslow, Lina Odqvist, Sarah Diver, Rebecca Riise, Suado Abdillahi, Cecilia Wingren, Helena Lindmark, Annika Wellner, Sofia Lundin, Linda Yrlid, Elisabeth Ax, Ratko Djukanovic, Sriram Sridhar, Andrew Higham, Dave Singh, Thomas Southworth, Christopher E. Brightling, Henric K. Olsson, Zala Jevnikar

    European Respiratory Journal 58 (4) 2003312; DOI: 10.1183/13993003.03312-2020 Published 14 October 2021

• Basic science and lung transplant

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    Association between the renin–angiotensin system and chronic lung allograft dysfunction

    Gregory Berra, Sofia Farkona, Zahraa Mohammed-Ali, Max Kotlyar, Liran Levy, Sergi Clotet-Freixas, Phillip Ly, Benjamin Renaud-Picard, Guan Zehong, Tina Daigneault, Allen Duong, Ihor Batruch, Igor Jurisica, Ana Konvalinka, Tereza Martinu

    European Respiratory Journal 58 (4) 2002975; DOI: 10.1183/13993003.02975-2020 Published 21 October 2021

• Basic science

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    Healthy versus inflamed lung environments differentially affect mesenchymal stromal cells

    Sara Rolandsson Enes, Thomas H. Hampton, Jayita Barua, David H. McKenna, Claudia C. dos Santos, Eyal Amiel, Alix Ashare, Kathleen D. Liu, Anna D. Krasnodembskaya, Karen English, Bruce A. Stanton, Patricia R.M. Rocco, Michael A. Matthay, Daniel J. Weiss

    European Respiratory Journal 58 (4) 2004149; DOI: 10.1183/13993003.04149-2020 Published 14 October 2021
  • Open Access

    Higher throughput drug screening for rare respiratory diseases: readthrough therapy in primary ciliary dyskinesia

    Dani Do Hyang Lee, Daniela Cardinale, Ersilia Nigro, Colin R. Butler, Andrew Rutman, Mahmoud R. Fassad, Robert A. Hirst, Dale Moulding, Alexander Agrotis, Elisabeth Forsythe, Daniel Peckham, Evie Robson, Claire M. Smith, Satyanarayana Somavarapu, Philip L. Beales, Stephen L. Hart, Sam M. Janes, Hannah M. Mitchison, Robin Ketteler, Robert E. Hynds, Christopher O'Callaghan

    European Respiratory Journal 58 (4) 2000455; DOI: 10.1183/13993003.00455-2020 Published 14 October 2021

• COPD

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    Blood eosinophil counts and the development of obstructive lung disease: the Kangbuk Samsung Health Study

    Hye Yun Park, Yoosoo Chang, Danbee Kang, Yun Soo Hong, Di Zhao, Jiin Ahn, Sun Hye Shin, Dave Singh, Eliseo Guallar, Juhee Cho, Seungho Ryu

    European Respiratory Journal 58 (4) 2003823; DOI: 10.1183/13993003.03823-2020 Published 7 October 2021

• Sleep

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    VE-cadherin cleavage in sleep apnoea: new insights into intermittent hypoxia-related endothelial permeability

    Olfa Harki, Renaud Tamisier, Jean-Louis Pépin, Sébastien Bailly, Anissa Mahmani, Brigitte Gonthier, Aude Salomon, Isabelle Vilgrain, Gilles Faury, Anne Briançon-Marjollet

    European Respiratory Journal 58 (4) 2004518; DOI: 10.1183/13993003.04518-2020 Published 7 October 2021
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    Impact of obstructive sleep apnoea and intermittent hypoxia on blood rheology: a translational study

    Xavier Waltz, Andrew E. Beaudin, Elise Belaidi, Jill Raneri, Jean-Louis Pépin, Vincent Pialoux, Patrick J. Hanly, Samuel Verges, Marc J. Poulin

    European Respiratory Journal 58 (4) 2100352; DOI: 10.1183/13993003.00352-2021 Published 7 October 2021