Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions

Risk factors associated with the development of interstitial lung abnormalities

Ivette Buendía-Roldán, Rosario Fernandez, Mayra Mejía, Fortunato Juarez, Gustavo Ramirez-Martinez, Eduardo Montes, Ana Karem S. Pruneda, Karen Martinez-Espinosa, Aime Alarcon-Dionet, Iliana Herrera, Carina Becerril, Leslie Chavez-Galan, Mario Preciado, Annie Pardo, Moisés Selman
European Respiratory Journal 2021 58: 2003005; DOI: 10.1183/13993003.03005-2020
Ivette Buendía-Roldán
1Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico City, Mexico
3These two authors contributed equally to this article as lead authors and supervised the work
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rosario Fernandez
1Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico City, Mexico
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mayra Mejía
1Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico City, Mexico
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Fortunato Juarez
1Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico City, Mexico
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gustavo Ramirez-Martinez
1Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico City, Mexico
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eduardo Montes
1Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico City, Mexico
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ana Karem S. Pruneda
1Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico City, Mexico
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Karen Martinez-Espinosa
1Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico City, Mexico
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Aime Alarcon-Dionet
1Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico City, Mexico
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Iliana Herrera
1Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico City, Mexico
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carina Becerril
1Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico City, Mexico
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Leslie Chavez-Galan
1Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico City, Mexico
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mario Preciado
1Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico City, Mexico
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Annie Pardo
2Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City, Mexico
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Moisés Selman
1Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico City, Mexico
3These two authors contributed equally to this article as lead authors and supervised the work
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Moisés Selman
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

Background Around 8–10% of individuals over 50 years of age present interstitial lung abnormalities (ILAs), but their risk factors are uncertain.

Methods From 817 individuals recruited in our lung ageing programme at the Mexican National Institute of Respiratory Diseases, 80 (9.7%) showed ILAs and were compared with 564 individuals of the same cohort with normal high-resolution computed tomography to evaluate demographic and functional differences, and with 80 individuals randomly selected from the same cohort for biomarkers. We evaluated MUC5B variant rs35705950, telomere length, and serum levels of matrix metalloproteinase (MMP)-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, interleukin (IL)-6, surfactant protein (SP)-D, α-Klotho and resistin.

Results Individuals with ILAs were usually males (p<0.005), older than controls (p<0.0001), smokers (p=0.01), with a greater frequency of MUC5B rs35705950 (OR 3.5, 95% CI 1.3–9.4; p=0.01), and reduced diffusing capacity of the lung for carbon monoxide and oxygen saturation. Resistin, IL-6, SP-D, MMP-1, MMP-7 and MMP-13 were significantly increased in individuals with ILAs. Resistin (12±5 versus 9±4 ng·mL−1; p=0.0005) and MMP-13 (357±143 versus 298±116 pg·mL−1; p=0.004) were the most increased biomarkers. On follow-up (24±18 months), 18 individuals showed progression which was associated with gastro-oesophageal reflux disease (OR 4.1, 95% CI 1.2–12.9; p=0.02) and in females with diabetes mellitus (OR 5.3, 95% CI 1.0–27.4; p=0.01).

Conclusions Around 10% of respiratory asymptomatic individuals enrolled in our lung ageing programme show ILAs. Increased serum concentrations of pro-inflammatory molecules and MMPs are associated with ILAs.

Abstract

Some individuals older than 50 years may present interstitial lung abnormalities which are associated with a greater risk of all-cause mortality. This study provides demographic and molecular factors which may help to identify individuals at higher risk. https://bit.ly/2Lc4y88

Footnotes

  • Author contributions: Designed the study: I. Buendía-Roldán and M. Selman. Data collection: A.K.S. Pruneda, K. Martinez-Espinosa and A. Alarcon-Dionet. Methodology: L. Chavez-Galan, R. Fernandez and I. Buendía-Roldán. Sample processing: G. Ramirez-Martinez, E. Montes, I. Herrera, C. Becerril, M. Preciado and L. Chavez-Galan. Review of clinical studies and provided input on clinical implications: I. Buendía-Roldán, M. Mejía, F. Juarez, A. Pardo and M. Selman. Administered the follow-up and analysed the data: A.K.S. Pruneda, A. Alarcon-Dionet, R. Fernandez, I. Buendía-Roldán, A. Pardo and M. Selman. Writing original draft: M. Selman. Manuscript review and editing: I. Buendía-Roldán, A. Pardo and M. Selman.

  • This article has supplementary material available from erj.ersjournals.com

  • Conflict of interest: I. Buendía-Roldán has nothing to disclose.

  • Conflict of interest: R. Fernandez has nothing to disclose.

  • Conflict of interest: M. Mejía has nothing to disclose.

  • Conflict of interest: F. Juarez has nothing to disclose.

  • Conflict of interest: G. Ramirez-Martinez has nothing to disclose.

  • Conflict of interest: E. Montes has nothing to disclose.

  • Conflict of interest: A.K.S. Pruneda has nothing to disclose.

  • Conflict of interest: K. Martinez-Espinosa has nothing to disclose.

  • Conflict of interest: A. Alarcon-Dionet has nothing to disclose.

  • Conflict of interest: I. Herrera has nothing to disclose.

  • Conflict of interest: C. Becerril has nothing to disclose.

  • Conflict of interest: L. Chavez-Galan has nothing to disclose.

  • Conflict of interest: M. Preciado has nothing to disclose.

  • Conflict of interest: A. Pardo has nothing to disclose.

  • Conflict of interest: M. Selman has nothing to disclose.

  • Support statement: This study was supported by Secretaría de Educación, Ciencia, Tecnología e Innovación de la Ciudad de Mexico grant SECITI/115/2017, and by CONACYT grant FOSISS 290645. Funding information for this article has been deposited with the Crossref Funder Registry.

  • Received August 2, 2020.
  • Accepted December 22, 2020.
  • Copyright ©The authors 2021. For reproduction rights and permissions contact permissions{at}ersnet.org
https://www.ersjournals.com/user-licence
View Full Text

ERS Members

myERS - ERS members : log in with your myERS username and password.

INDIVIDUALS

Log in Login as an individual user.

Forgot your username or password?

LIBRARY USERS

Log in through your institution

If your library has a subscription, you may already be logged in via your IP address. Otherwise you may be able to log in via one of the following routes.
You may be able to gain access using your login credentials for your institution. Contact your library if you do not have a username and password.
If your organization uses OpenAthens, you can log in using your OpenAthens username and password. To check if your institution is supported, please see this list. Contact your library for more details.
If you think you should have access, please contact your librarian or email journals@ersnet.org

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top
View this article with LENS
Vol 58 Issue 2 Table of Contents
European Respiratory Journal: 58 (2)
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Risk factors associated with the development of interstitial lung abnormalities
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
Citation Tools
Risk factors associated with the development of interstitial lung abnormalities
Ivette Buendía-Roldán, Rosario Fernandez, Mayra Mejía, Fortunato Juarez, Gustavo Ramirez-Martinez, Eduardo Montes, Ana Karem S. Pruneda, Karen Martinez-Espinosa, Aime Alarcon-Dionet, Iliana Herrera, Carina Becerril, Leslie Chavez-Galan, Mario Preciado, Annie Pardo, Moisés Selman
European Respiratory Journal Aug 2021, 58 (2) 2003005; DOI: 10.1183/13993003.03005-2020

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Risk factors associated with the development of interstitial lung abnormalities
Ivette Buendía-Roldán, Rosario Fernandez, Mayra Mejía, Fortunato Juarez, Gustavo Ramirez-Martinez, Eduardo Montes, Ana Karem S. Pruneda, Karen Martinez-Espinosa, Aime Alarcon-Dionet, Iliana Herrera, Carina Becerril, Leslie Chavez-Galan, Mario Preciado, Annie Pardo, Moisés Selman
European Respiratory Journal Aug 2021, 58 (2) 2003005; DOI: 10.1183/13993003.03005-2020
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
    • Abstract
    • Abstract
    • Introduction
    • Material and methods
    • Results
    • Discussion
    • Supplementary material
    • Shareable PDF
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

Original Research Articles

  • Intrapulmonary shunt and alveolar dead space in COVID-19
  • OSA and cardiovascular events in patients with acute coronary syndrome
  • COVID-19 and case fatality in pulmonary embolism
Show more Original Research Articles

Interstitial lung disease

  • Nintedanib plus chemotherapy for NSCLC with IPF
  • Interstitial lung abnormalities are associated with decreased telomere length
  • Fine particulate matter components and ILD in rheumatoid arthritis
Show more Interstitial lung disease

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society