Table of Contents

Original Research Articles

• Pulmonary vascular disease

  • Open Access

    Screening for pulmonary arterial hypertension in adults carrying a BMPR2 mutation

    David Montani, Barbara Girerd, Xavier Jaïs, Pierantonio Laveneziana, Edmund M.T. Lau, Amir Bouchachi, Sébastien Hascoët, Sven Günther, Laurent Godinas, Florence Parent, Christophe Guignabert, Antoine Beurnier, Denis Chemla, Philippe Hervé, Mélanie Eyries, Florent Soubrier, Gérald Simonneau, Olivier Sitbon, Laurent Savale, Marc Humbert

    European Respiratory Journal 58 (1) 2004229; DOI: 10.1183/13993003.04229-2020 Published 22 July 2021

• COPD

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    Can simvastatin reduce COPD exacerbations? A randomised double-blind controlled study

    Peter Schenk, Alexander O. Spiel, Felix Hüttinger, Micheline Gmeiner, Josefine Fugger, Martina Pichler, Gernot Pichler, Susanne Schmeikal, Wolfgang Janistyn, Stefan Schügerl, Constantin Sajdik, Harald Herkner

    European Respiratory Journal 58 (1) 2001798; DOI: 10.1183/13993003.01798-2020 Published 29 July 2021

• COPD and the environment

  • Open Access

    Personal exposure to air pollution and respiratory health of COPD patients in London

    Dimitris Evangelopoulos, Lia Chatzidiakou, Heather Walton, Klea Katsouyanni, Frank J. Kelly, Jennifer K. Quint, Roderic L. Jones, Benjamin Barratt

    European Respiratory Journal 58 (1) 2003432; DOI: 10.1183/13993003.03432-2020 Published 20 July 2021

• Cystic fibrosis

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    Longitudinal course of clinical lung clearance index in children with cystic fibrosis

    Bettina S. Frauchiger, Severin Binggeli, Sophie Yammine, Ben Spycher, Linn Krüger, Kathryn A. Ramsey, Philipp Latzin

    European Respiratory Journal 58 (1) 2002686; DOI: 10.1183/13993003.02686-2020 Published 8 July 2021
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    Determinants of lung disease progression measured by lung clearance index in children with cystic fibrosis

    Sanja Stanojevic, Stephanie D. Davis, Lucy Perrem, Michelle Shaw, George Retsch-Bogart, Miriam Davis, Renee Jensen, Charles C. Clem, Sarah M. Isaac, Julia Guido, Sylvia Jara, Lisa France, Nancy McDonald, Melinda Solomon, Neil Sweezey, Hartmut Grasemann, Valerie Waters, D.B. Sanders, Felix A. Ratjen

    European Respiratory Journal 58 (1) 2003380; DOI: 10.1183/13993003.03380-2020 Published 8 July 2021

• Interstitial lung disease

  • Open Access

    Monocytes in sarcoidosis are potent tumour necrosis factor producers and predict disease outcome

    Rico Lepzien, Sang Liu, Paulo Czarnewski, Mu Nie, Björn Österberg, Faezzah Baharom, Jamshid Pourazar, Gregory Rankin, Anders Eklund, Matteo Bottai, Susanna Kullberg, Anders Blomberg, Johan Grunewald, Anna Smed-Sörensen

    European Respiratory Journal 58 (1) 2003468; DOI: 10.1183/13993003.03468-2020 Published 22 July 2021
  • Open Access

    Home spirometry in patients with idiopathic pulmonary fibrosis: data from the INMARK trial

    Imre Noth, Vincent Cottin, Nazia Chaudhuri, Tamera J. Corte, Kerri A. Johannson, Marlies Wijsenbeek, Stephane Jouneau, Andreas Michael, Manuel Quaresma, Klaus B. Rohr, Anne-Marie Russell, Susanne Stowasser, Toby M. Maher on behalf of the INMARK trial investigators

    European Respiratory Journal 58 (1) 2001518; DOI: 10.1183/13993003.01518-2020 Published 8 July 2021

• Tuberculosis

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    Optimising pyrazinamide for the treatment of tuberculosis

    Nan Zhang, Radojka M. Savic, Martin J. Boeree, Charles A. Peloquin, Marc Weiner, Norbert Heinrich, Erin Bliven-Sizemore, Patrick P.J. Phillips, Michael Hoelscher, William Whitworth, Glenn Morlock, James Posey, Jason E. Stout, William Mac Kenzie, Robert Aarnoutse, Kelly E. Dooley the Tuberculosis Trials Consortium (TBTC) and Pan African Consortium for the Evaluation of Antituberculosis Antibiotics (PanACEA) Networks

    European Respiratory Journal 58 (1) 2002013; DOI: 10.1183/13993003.02013-2020 Published 20 July 2021
  • Open Access

    Increased bactericidal activity but dose-limiting intolerability at 50 mg·kg⁻¹ rifampicin

    Lindsey H.M. te Brake, Veronique de Jager, Kim Narunsky, Naadira Vanker, Elin M. Svensson, Patrick P.J. Phillips, Stephen H. Gillespie, Norbert Heinrich, Michael Hoelscher, Rodney Dawson, Andreas H. Diacon, Rob E. Aarnoutse, Martin J. Boeree on behalf of the PanACEA Consortium

    European Respiratory Journal 58 (1) 2000955; DOI: 10.1183/13993003.00955-2020 Published 8 July 2021

• Pulmonary infection

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    Functional lower airways genomic profiling of the microbiome to capture active microbial metabolism

    Imran Sulaiman, Benjamin G. Wu, Yonghua Li, Jun-Chieh Tsay, Maya Sauthoff, Adrienne S. Scott, Kun Ji, Sergei B. Koralov, Michael Weiden, Jose C. Clemente, Drew Jones, Yvonne J. Huang, Kathleen A. Stringer, Lingdi Zhang, Adam Geber, Stephanie Banakis, Laura Tipton, Elodie Ghedin, Leopoldo N. Segal

    European Respiratory Journal 58 (1) 2003434; DOI: 10.1183/13993003.03434-2020 Published 29 July 2021
  • Open Access

    Diffusion capacity abnormalities for carbon monoxide in patients with COVID-19 at 3-month follow-up

    Wei Qin, Shi Chen, Yunxia Zhang, Fen Dong, Zhu Zhang, Bingzhu Hu, Ziyang Zhu, Fajiu Li, Xiaojiang Wang, Yimin Wang, Kaiyuan Zhen, Jing Wang, YuLei Wan, Hongbo Li, Ismaïl Elalamy, Chenghong Li, Zhenguo Zhai, Chen Wang

    European Respiratory Journal 58 (1) 2003677; DOI: 10.1183/13993003.03677-2020 Published 22 July 2021
  • Open Access

    Dynamics of SARS-CoV-2 shedding in the respiratory tract depends on the severity of disease in COVID-19 patients

    Dieter Munker, Andreas Osterman, Hans Stubbe, Maximilian Muenchhoff, Tobias Veit, Tobias Weinberger, Michaela Barnikel, Jan-Niclas Mumm, Katrin Milger, Elham Khatamzas, Sarah Klauss, Clemens Scherer, Johannes C. Hellmuth, Clemens Giessen-Jung, Michael Zoller, Tobias Herold, Stephanie Stecher, Enrico N. de Toni, Christian Schulz, Nikolaus Kneidinger, Oliver T. Keppler, Jürgen Behr, Julia Mayerle, Stefan Munker

    European Respiratory Journal 58 (1) 2002724; DOI: 10.1183/13993003.02724-2020 Published 20 July 2021
  • Open Access

    Early use of nitazoxanide in mild COVID-19 disease: randomised, placebo-controlled trial

    Patricia R.M. Rocco, Pedro L. Silva, Fernanda F. Cruz, Marco Antonio C. Melo-Junior, Paulo F.G.M.M. Tierno, Marcos A. Moura, Luís Frederico G. De Oliveira, Cristiano C. Lima, Ezequiel A. Dos Santos, Walter F. Junior, Ana Paula S.M. Fernandes, Kleber G. Franchini, Erick Magri, Nara F. de Moraes, José Mário J. Gonçalves, Melanie N. Carbonieri, Ivonise S. Dos Santos, Natália F. Paes, Paula V.M. Maciel, Raissa P. Rocha, Alex F. de Carvalho, Pedro Augusto Alves, José Luiz Proença-Módena, Artur T. Cordeiro, Daniela B.B. Trivella, Rafael E. Marques, Ronir R. Luiz, Paolo Pelosi, Jose Roberto Lapa e Silva on behalf of the SARITA-2 investigators

    European Respiratory Journal 58 (1) 2003725; DOI: 10.1183/13993003.03725-2020 Published 8 July 2021

• Asthma

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    A real-life comparative effectiveness study into the addition of antibiotics to the management of asthma exacerbations in primary care

    Clare S. Murray, Sarah J. Lucas, John Blakey, Alan Kaplan, Alberto Papi, James Paton, Wanda Phipatanakul, David Price, Oon Hoe Teoh, Mike Thomas, Steve Turner, Nikolaos G. Papadopoulos

    European Respiratory Journal 58 (1) 2003599; DOI: 10.1183/13993003.03599-2020 Published 1 July 2021

• Cancer and thrombosis

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    Clinical characteristics and 3-month outcomes in cancer patients with incidental versus clinically suspected and confirmed pulmonary embolism

    Marisa Peris, Juan J. López-Nuñez, Ana Maestre, David Jimenez, Alfonso Muriel, Behnood Bikdeli, Ido Weinberg, Cihan Ay, Lucia Mazzolai, Alicia Lorenzo, Manuel Monreal, the RIETE Investigators

    European Respiratory Journal 58 (1) 2002723; DOI: 10.1183/13993003.02723-2020 Published 1 July 2021

• Asthma and basic science

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    A-to-I editing of miR-200b-3p in airway cells is associated with moderate-to-severe asthma

    Kevin M. Magnaye, Katherine A. Naughton, Janel Huffman, D. Kyle Hogarth, Edward T. Naureckas, Steven R. White, Carole Ober

    European Respiratory Journal 58 (1) 2003862; DOI: 10.1183/13993003.03862-2020 Published 29 July 2021

• Acute lung injury and basic science

  • Open Access

    Mesenchymal stromal cell extracellular vesicles rescue mitochondrial dysfunction and improve barrier integrity in clinically relevant models of ARDS

    Johnatas Dutra Silva, Yue Su, Carolyn S. Calfee, Kevin L. Delucchi, Daniel Weiss, Danny F. McAuley, Cecilia O'Kane, Anna D. Krasnodembskaya

    European Respiratory Journal 58 (1) 2002978; DOI: 10.1183/13993003.02978-2020 Published 1 July 2021

• Interstitial lung disease and basic science

  • Open Access

    An integrated multiomic and quantitative label-free microscopy-based approach to study pro-fibrotic signalling in ex vivo human precision-cut lung slices

    Muzamil Majid Khan, Daniel Poeckel, Aliaksandr Halavatyi, Joanna Zukowska-Kasprzyk, Frank Stein, Johanna Vappiani, Daniel C. Sevin, Christian Tischer, Nico Zinn, Jessica D. Eley, Natasja Stæhr Gudmann, Thomas Muley, Hauke Winter, Andrew J. Fisher, Carmel B. Nanthakumar, Giovanna Bergamini, Rainer Pepperkok

    European Respiratory Journal 58 (1) 2000221; DOI: 10.1183/13993003.00221-2020 Published 1 July 2021

    • Supplementary tables

• Infection and basic science

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    TLR2-mediated innate immune priming boosts lung anti-viral immunity

    Jason Girkin, Su-Ling Loo, Camille Esneau, Steven Maltby, Francesca Mercuri, Brendon Chua, Andrew T. Reid, Punnam Chander Veerati, Chris L. Grainge, Peter A.B. Wark, Darryl Knight, David Jackson, Christophe Demaison, Nathan W. Bartlett

    European Respiratory Journal 58 (1) 2001584; DOI: 10.1183/13993003.01584-2020 Published 1 July 2021
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    Influenza virus infection increases ACE2 expression and shedding in human small airway epithelial cells

    Kelly S. Schweitzer, Taylor Crue, Jordan M. Nall, Daniel Foster, Satria Sajuthi, Kelly A. Correll, Mari Nakamura, Jamie L. Everman, Gregory P. Downey, Max A. Seibold, James P. Bridges, Karina A. Serban, Hong Wei Chu, Irina Petrache

    European Respiratory Journal 58 (1) 2003988; DOI: 10.1183/13993003.03988-2020 Published 1 July 2021