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Plasma ACE2 activity is persistently elevated following SARS-CoV-2 infection: implications for COVID-19 pathogenesis and consequences

Sheila K. Patel, Jennifer A. Juno, Wen Shi Lee, Kathleen M. Wragg, P. Mark Hogarth, Stephen J. Kent, Louise M. Burrell
European Respiratory Journal 2021 57: 2003730; DOI: 10.1183/13993003.03730-2020
Sheila K. Patel
1Dept of Medicine, Austin Health, University of Melbourne, Melbourne, Australia
4Contributed equally
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Jennifer A. Juno
2Dept of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
4Contributed equally
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Wen Shi Lee
2Dept of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
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Kathleen M. Wragg
2Dept of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
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P. Mark Hogarth
3Immune Therapies Group, Burnet Institute, Melbourne, Australia
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Stephen J. Kent
2Dept of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
5S.J. Kent and L.M. Burrell contributed equally to this article as lead authors and supervised the work
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Louise M. Burrell
1Dept of Medicine, Austin Health, University of Melbourne, Melbourne, Australia
5S.J. Kent and L.M. Burrell contributed equally to this article as lead authors and supervised the work
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  • ORCID record for Louise M. Burrell
  • For correspondence: l.burrell@unimelb.edu.au
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Article Information

vol. 57 no. 5
DOI 
https://doi.org/10.1183/13993003.03730-2020
PubMed 
33479113

Published By 
European Respiratory Society
Print ISSN 
0903-1936
Online ISSN 
1399-3003
History 
  • Received October 6, 2020
  • Accepted January 3, 2021
  • Published online May 13, 2021.

Article Versions

  • previous version (January 21, 2021 - 06:24).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright ©The authors 2021 This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org

Author Information

  1. Sheila K. Patel1,4,
  2. Jennifer A. Juno2,4,
  3. Wen Shi Lee2,
  4. Kathleen M. Wragg2,
  5. P. Mark Hogarth3,
  6. Stephen J. Kent2,5 and
  7. Louise M. Burrell1,5⇑
  1. 1Dept of Medicine, Austin Health, University of Melbourne, Melbourne, Australia
  2. 2Dept of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
  3. 3Immune Therapies Group, Burnet Institute, Melbourne, Australia
  4. 4Contributed equally
  5. 5S.J. Kent and L.M. Burrell contributed equally to this article as lead authors and supervised the work
  1. Louise M. Burrell, Dept of Medicine, University of Melbourne, Lance Townsend Building, Austin Health, Studley Road, Melbourne, Victoria 3084, Australia. E-mail: l.burrell{at}unimelb.edu.au
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Funding

  • State Government of Victoria

  • Medical Research Future Fund

    1175865 and 2002073
  • National Health and Medical Research Council

    1149990, 1055214, 145303
  • ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

    140100036

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European Respiratory Journal: 57 (5)
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Plasma ACE2 activity is persistently elevated following SARS-CoV-2 infection: implications for COVID-19 pathogenesis and consequences
Sheila K. Patel, Jennifer A. Juno, Wen Shi Lee, Kathleen M. Wragg, P. Mark Hogarth, Stephen J. Kent, Louise M. Burrell
European Respiratory Journal May 2021, 57 (5) 2003730; DOI: 10.1183/13993003.03730-2020

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Plasma ACE2 activity is persistently elevated following SARS-CoV-2 infection: implications for COVID-19 pathogenesis and consequences
Sheila K. Patel, Jennifer A. Juno, Wen Shi Lee, Kathleen M. Wragg, P. Mark Hogarth, Stephen J. Kent, Louise M. Burrell
European Respiratory Journal May 2021, 57 (5) 2003730; DOI: 10.1183/13993003.03730-2020
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