Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions

Free-breathing MRI for monitoring ventilation changes following antibiotic treatment of pulmonary exacerbations in paediatric cystic fibrosis

Samal Munidasa, Marcus J. Couch, Jonathan H. Rayment, Andreas Voskrebenzev, Ravi Seethamraju, Jens Vogel-Claussen, Felix Ratjen, Giles Santyr
European Respiratory Journal 2021 57: 2003104; DOI: 10.1183/13993003.03104-2020
Samal Munidasa
1Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada
2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marcus J. Couch
1Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada
2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jonathan H. Rayment
3Division of Respiratory Medicine, British Columbia Children's Hospital, Vancouver, BC, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jonathan H. Rayment
Andreas Voskrebenzev
4Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany
5Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ravi Seethamraju
6MR Collaborations North East, Siemens Medical Solutions, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Ravi Seethamraju
Jens Vogel-Claussen
4Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany
5Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Felix Ratjen
1Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada
7Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Giles Santyr
1Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada
2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: giles.santyr@sickkids.ca
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Extract

Treatment response in cystic fibrosis (CF) is traditionally monitored using pulmonary function tests (PFTs), such as spirometry. However, PFTs can be insensitive to treatment, particularly in early CF lung disease [1]. Hyperpolarised xenon-129 magnetic resonance imaging (Xe-MRI) has been shown to be feasible in children [2], more sensitive to early CF lung disease compared to PFTs [3] and captures improvements in ventilation inhomogeneity in paediatric CF patients receiving intravenous antibiotic treatment for a pulmonary exacerbation [4]. However, access to hyperpolarised 129Xe gas is not widely available, and Xe-MRI requires subjects to perform an extended breath-hold (10–15 s), which is challenging for very sick children.

Abstract

Ventilation distributions obtained with PREFUL MRI correlated with Xe-MRI, and both could detect improvements following treatment of a PEx. PREFUL MRI offers an effective and more widely available alternative to Xe-MRI for monitoring treatment. https://bit.ly/3le0TT9

Acknowledgements

The authors would like to thank: Shahideh Safavi, Yonni Friedlander, Robert Grimm, Raymond Hu, Nikhil Kanhere, Krzysztof Kowalik, Andras Lindenmaier, Tammy Rayner, Laura Seed, Elaine Stirrat, Ruth Weiss, David Wilson, and Brandon Zanette for their assistance with data acquisition and analysis.

Footnotes

  • The work was carried out using REB and Health Canada-approved protocols at the Hospital for Sick Children (clinicaltrials.gov: NCT02740868, for PEx participants, and NCT02606487, for healthy volunteers). Individual participant data will not be shared.

  • Author contributions: Study design: F. Ratjen and G. Santyr; data collection: M.J. Couch and J.H. Rayment; analysis: S. Munidasa, J.H. Rayment, M.J. Couch and G. Santyr; manuscript drafting, editing and approval: all.

  • Conflict of interest: M.J. Couch reports that he was supported by a MITACS Elevate Postdoctoral Fellowship, which was funded in part by Siemens Healthcare Limited, and is currently an employee of Siemens Healthcare Limited. This employment began after the conclusion of the study.

  • Conflict of interest: J.H. Rayment reports consultancy fees from Polarean Inc, outside the submitted work.

  • Conflict of interest: A. Voskrebenzev has a patent “Method of quantitative magnetic resonance lung imaging” licensed to Siemens.

  • Conflict of interest: R. Seethamraju is an employee of Siemens Medical Solutions, USA Inc.

  • Conflict of interest: J. Vogel-Claussen reports grants from Siemens Healthineers, during the conduct of the study; grants and personal fees from Boehringer Ingelheim and AstraZeneca, grants from GSK, outside the submitted work; and has a patent “Method of quantitative magnetic resonance lung imaging” number EP3107066, US-2016-0367200-A1 22.12.2016 licensed to Siemens Healthineers.

  • Conflict of interest: F. Ratjen has nothing to disclose.

  • Conflict of interest: G. Santyr reports grants and non-financial support from Siemens Healthineers, grants from Canadian Institutes of Health Research, during the conduct of the study; grants and non-financial support from Siemens Healthineers, outside the submitted work.

  • Conflict of interest: S. Munidasa reports grants from Cystic Fibrosis Centre, Natural Sciences and Engineering Research Council of Canada and Canadian Institutes of Health Research, during the conduct of the study.

  • Support statement: The Hospital for Sick Children (Catalyst Grant from the Cystic Fibrosis Centre), Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery grant (RGPIN 217015-2013), Canadian Institutes of Health Research (CIHR) operating and project grants (MOP 123431, PJT 153099, PJT 376120), and The Irwin Fund. Funding information for this article has been deposited with the Crossref Funder Registry.

  • Received August 12, 2020.
  • Accepted November 22, 2020.
  • Copyright ©ERS 2021
https://www.ersjournals.com/user-licence
View Full Text

ERS Members

myERS - ERS members : log in with your myERS username and password.

INDIVIDUALS

Log in Login as an individual user.

Forgot your username or password?

LIBRARY USERS

Log in through your institution

If your library has a subscription, you may already be logged in via your IP address. Otherwise you may be able to log in via one of the following routes.
You may be able to gain access using your login credentials for your institution. Contact your library if you do not have a username and password.
If your organization uses OpenAthens, you can log in using your OpenAthens username and password. To check if your institution is supported, please see this list. Contact your library for more details.
If you think you should have access, please contact your librarian or email journals@ersnet.org

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top
View this article with LENS
Vol 57 Issue 4 Table of Contents
European Respiratory Journal: 57 (4)
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Free-breathing MRI for monitoring ventilation changes following antibiotic treatment of pulmonary exacerbations in paediatric cystic fibrosis
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
Citation Tools
Free-breathing MRI for monitoring ventilation changes following antibiotic treatment of pulmonary exacerbations in paediatric cystic fibrosis
Samal Munidasa, Marcus J. Couch, Jonathan H. Rayment, Andreas Voskrebenzev, Ravi Seethamraju, Jens Vogel-Claussen, Felix Ratjen, Giles Santyr
European Respiratory Journal Apr 2021, 57 (4) 2003104; DOI: 10.1183/13993003.03104-2020

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Free-breathing MRI for monitoring ventilation changes following antibiotic treatment of pulmonary exacerbations in paediatric cystic fibrosis
Samal Munidasa, Marcus J. Couch, Jonathan H. Rayment, Andreas Voskrebenzev, Ravi Seethamraju, Jens Vogel-Claussen, Felix Ratjen, Giles Santyr
European Respiratory Journal Apr 2021, 57 (4) 2003104; DOI: 10.1183/13993003.03104-2020
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
    • Abstract
    • Shareable PDF
    • Acknowledgements
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

Agora

  • Mortality after admission with pneumonia higher than after admission with COPD exacerbation
  • Balancing the risks and benefits of in-circuit bacterial filters
  • Polyurethane foam degradation in CPAP devices for sleep apnoea
Show more Agora

Research letters

  • P. aeruginosa membrane vesicles cause endothelial barrier failure
  • Mortality after admission with pneumonia higher than after admission with COPD exacerbation
  • Polyurethane foam degradation in CPAP devices for sleep apnoea
Show more Research letters

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2022 by the European Respiratory Society