Extract
We read with much interest the study by Verbanck et al. [1], which showed that multiple breath washout (MBW) protocols with fixed tidal volume (VT) ranges tend to decrease acinar and conductive airway ventilation heterogeneity (Sacin and Scond) variability, improve VT normalisation methods and shorten test duration in healthy adults. However, we question whether direct extrapolation of the results of Verbanck et al. [1] to children and subjects with lung disease, as suggested by the authors, is appropriate.
Abstract
Direct extrapolation of fixed breathing pattern recommendations for multiple breath washout in healthy adults to children and patients with lung disease requires caution https://bit.ly/39vVGSK
Footnotes
Conflict of interest: A-C. Kentgens has nothing to disclose.
Conflict of interest: P. Latzin reports personal fees from Gilead, Novartis, OM Pharma, Polyphor, Roche, Santhera, Schwabe, Vertex, Vifor and Zambon, and grants from Vertex, all outside the submitted work.
Conflict of interest: S. Yammine has nothing to disclose.
Support statement: The work was supported by Swiss National Science Foundation grant number 179905 to Sophie Yammine and 182719 to Philipp Latzin. Anne-Christianne Kentgens is a recipient of the Swiss Government Excellence Scholarship from The Swiss Confederation. Funding information for this article has been deposited with the Crossref Funder Registry.
- Received January 1, 2021.
- Accepted January 3, 2021.
- ©The authors 2021. For reproduction rights and permissions contact permissions{at}ersnet.org
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