Extract
We read with great interest the recent manuscript by Bouvard et al. [1], which suggested the gap junctional protein connexin-43 (Cx43) to be a promising target for the treatment of chronic hypoxic pulmonary hypertension (CHPH). Therein, the authors demonstrated increased Cx43 expression in human pulmonary arteries of CHPH patients, while heterozygous Cx43 deficient mice were partially protected from CHPH.
Abstract
Gap junctions, composed of connexins 37, 40 or 43, mediate the pulmonary vascular response to acute and chronic hypoxia as they propagate the hypoxic signal from the site of gas exchange retrogradely to the feeding arteri(ol)es https://bit.ly/3orJKXM
Footnotes
Conflict of interest: M. Witzenrath has nothing to disclose.
Conflict of interest: W.M. Kuebler has nothing to disclose.
- Received December 19, 2020.
- Accepted January 20, 2021.
- ©The authors 2021. For reproduction rights and permissions contact permissions{at}ersnet.org
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