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Minimal clinically important differences for Dyspnea-12 and MDP scores are similar at 2 weeks and 6 months: follow-up of a longitudinal clinical study

Magnus Ekström, Hans Bornefalk, C. Magnus Sköld, Christer Janson, Anders Blomberg, Jacob Sandberg, Anna Bornefalk-Hermansson, David C. Currow, Miriam J. Johnson, Josefin Sundh
European Respiratory Journal 2021 57: 2002823; DOI: 10.1183/13993003.02823-2020
Magnus Ekström
1Lund University, Faculty of Medicine, Dept of Clinical Sciences Lund, Respiratory Medicine and Allergology, Lund, Sweden
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  • ORCID record for Magnus Ekström
Hans Bornefalk
2Hans Bornefalk AB, Vallentuna, Sweden
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C. Magnus Sköld
3Respiratory Medicine Unit, Dept of Medicine Solna and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
4Dept of Respiratory Medicine and Allergy, Karolinska University Hospital Solna, Stockholm, Sweden
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Christer Janson
5Dept of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden
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Anders Blomberg
6Dept of Public Health and Clinical Medicine, Section of Medicine, Umeå University, Umeå, Sweden
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Jacob Sandberg
1Lund University, Faculty of Medicine, Dept of Clinical Sciences Lund, Respiratory Medicine and Allergology, Lund, Sweden
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Anna Bornefalk-Hermansson
7Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
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David C. Currow
8IMPACCT, Faculty of Health, University of Technology Sydney, Ultimo, Australia
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Miriam J. Johnson
9Wolfson Palliative Care Research Centre, University of Hull, Hull, UK
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Josefin Sundh
10Dept of Respiratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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Extract

Chronic breathlessness is a dominating symptom that restricts daily life for many people with cardiorespiratory disease [1]. Different dimensions of the symptom, such as the intensity, sensory qualities and emotional responses, can be assessed using the instruments Dyspnea-12 (D-12) [2] and the Multidimensional Dyspnea Profile (MDP) [3], which share similarities in the underlying constructs of what is measured [4] and have emerged as widely used instruments for multi-dimensional measurement of breathlessness.

Abstract

This paper reports minimal clinically important differences (MCIDs) for measuring different aspects of breathlessness using the instruments D-12 and MDP at long-term follow-up (6 months), which were similar to MCIDs at short-term (2 week) assessment https://bit.ly/36r8BnK

Acknowledgements

The authors thank research nurse Lisa Carlson, Dept Respiratory Medicine and Allergy, Karolinska University Hospital Solna, research nurse Karin Johansson, Dept of Cardiology, Örebro University Hospital, Helena Igelström, Dept of Neuroscience, Uppsala University, and all nurses and staff who were involved in conducting the study and caring for the patients.

Footnotes

  • Conflict of interest: M. Ekström has nothing to disclose.

  • Conflict of interest: H. Bornefalk has nothing to disclose.

  • Conflict of interest: C.M. Sköld has nothing to disclose.

  • Conflict of interest: C. Janson has nothing to disclose.

  • Conflict of interest: A. Blomberg has nothing to disclose.

  • Conflict of interest: J. Sandberg has nothing to disclose.

  • Conflict of interest: A. Bornefalk-Hermansson has nothing to disclose.

  • Conflict of interest: D.C. Currow is an unpaid advisory board member for Helsinn Pharmaceuticals, is a paid consultant and receives payment for intellectual property with Mayne Pharma, and is a consultant with Specialised Therapeutics Australia Pty. Ltd.

  • Conflict of interest: M.J. Johnson has nothing to disclose.

  • Conflict of interest: J. Sundh has nothing to disclose.

  • Support statement: The study was funded by unrestricted grants from the Swedish Respiratory Society, the Swedish Heart-Lung Foundation, the Swedish Society for Medical Research and the Swedish Research Council (Dnr: 2019-02081). Funding information for this article has been deposited with the Crossref Funder Registry.

  • Received July 17, 2020.
  • Accepted November 5, 2020.
  • Copyright ©ERS 2021
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Minimal clinically important differences for Dyspnea-12 and MDP scores are similar at 2 weeks and 6 months: follow-up of a longitudinal clinical study
Magnus Ekström, Hans Bornefalk, C. Magnus Sköld, Christer Janson, Anders Blomberg, Jacob Sandberg, Anna Bornefalk-Hermansson, David C. Currow, Miriam J. Johnson, Josefin Sundh
European Respiratory Journal Mar 2021, 57 (3) 2002823; DOI: 10.1183/13993003.02823-2020

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Minimal clinically important differences for Dyspnea-12 and MDP scores are similar at 2 weeks and 6 months: follow-up of a longitudinal clinical study
Magnus Ekström, Hans Bornefalk, C. Magnus Sköld, Christer Janson, Anders Blomberg, Jacob Sandberg, Anna Bornefalk-Hermansson, David C. Currow, Miriam J. Johnson, Josefin Sundh
European Respiratory Journal Mar 2021, 57 (3) 2002823; DOI: 10.1183/13993003.02823-2020
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