Supplementary Material
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Supplementary methods, results and tables. ERJ-00754-2020.Supplement
Figure E1. Resting lung volumes in sitting and supine positions in patients with advanced COPD and age-matched healthy controls. Note the significant increase in inspiratory capacity (IC) in healthy controls while supine by 0.48 L (p<0.001) as a result of reduced EELV; assuming total lung capacity did not change with posture. The small sitting IC remained unaltered while supine in patients with COPD. EELV: end-expiratory lung volume; IRV: inspiratory reserve volume; VT: tidal volume. ERJ-00754-2020.Figure_E1
Figure E2. Qualitative dyspnoea descriptors using the modified 10-point Borg scale in sitting and supine positions in patients with advanced COPD. Boxes depict the first to third quartiles; central lines denote the median. Whiskers range from the 10th to the 90th percentile. *: p<0.05 sitting versus supine in patients with COPD. ERJ-00754-2020.Figure_E2
Figure E3. Individual diaphragm electromyography (EMGdi) data are shown in patients with advanced COPD and age-matched healthy controls (CTRL). Data are shown as absolute tidal inspiratory EMGdi (panels (a) and (b)) and as maximum values during serial sniff or inspiratory capacity manoeuvres (EMGdi,max) (panels (c) and (d)) in supine and sitting positions. Square symbols represent mean values. *: p<0.05 sitting versus supine in patients or CTRL. ERJ-00754-2020.Figure_E3
Figure E4. Individual trans-diaphragmatic pressure (Pdi) data are shown in patients with advanced COPD and age-matched healthy controls (CTRL). Data are shown as absolute tidal Pdi (panels (a) and (b)) and as maximum values during serial sniff manoeuvres (Pdi,max) (panels (c) and (d)) in supine and sitting positions. Square symbols represent mean values. *: p<0.05 sitting versus supine in patients or CTRL. ERJ-00754-2020.Figure_E4