FIGURE 4 Hypoxia-inducible factor (HIF)2α-inhibition restores plasma nitrite levels. a–d) Plasma cytokines and cardiac stress factor analysis a) tumour necrosis factor (TNF)-α, b) interleukin (IL)-10, (Nx-veh n=8, Su/Hx n=12, Su/Hx-veh n=15, Su/Hx-PT2567 n=11, Su/Hx-sildenafil n=14). c) c-Troponin-I (c-TnI), d) fatty acid binding protein-3 (FABP3) (Nx/Veh n=6, Su/Hx-3w n=6, Su/Hx-veh n=8, Su/Hx-PT2567 n=8, Su/Hx-sildenafil n=8). e) Plasma nitrite assessed by nitric oxide analyser (Sievers) (Nx/veh n=8, Su/Hx-3w n=12, Su/Hx-veh n=15, Su/Hx-PT2567 n=11, Su/Hx-sildenafil n=14). Data are presented as mean±sd. Nx: normoxia; veh: vehicle; Su/Hx: su5416/hypoxia; sil: sildenafil. *: p<0.05, **: p<0.001, ***: p<0.0001 (one-way ANOVA).