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Reply: BAL lymphocyte percentage is as good as the company it keeps

Nicola Adderley, Christopher J. Humphreys, Hayley Barnes, Zahra A. Premji, Kerri A. Johannson
European Respiratory Journal 2021 57: 2100092; DOI: 10.1183/13993003.00092-2021
Nicola Adderley
1Dept of Medicine, University of Calgary, Calgary, AB, Canada
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Christopher J. Humphreys
2Dept of Medicine, University of Toronto, Toronto, ON, Canada
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Hayley Barnes
3Dept of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Melbourne, Australia
4Dept of Medicine, University of California, San Francisco, San Francisco, CA, USA
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Zahra A. Premji
5Depts of Libraries and Cultural Resources, University of Calgary, Calgary, AB, Canada
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Kerri A. Johannson
1Dept of Medicine, University of Calgary, Calgary, AB, Canada
6Dept of Community Health Sciences, University of Calgary, Calgary, AB, Canada
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Extract

We thank O. Moran-Mendoza and M. Khalil for their interest in our work. In their correspondence, they highlight differences between our findings and others, suggesting a re-analysis of our data after excluding studies that used bronchoalveolar lavage (BAL) lymphocyte % as part of the diagnostic criteria for fibrotic hypersensitivity pneumonitis (HP), in an effort to reduce incorporation bias. Given the absence of studies meeting these criteria, we find this suggestion unfeasible.

Abstract

No single value of BAL lymphocyte % in fibrotic hypersensitivity pneumonitis will be diagnostic for all, and it must be considered in the context of other clinical, radiological and histopathological features https://bit.ly/3qSwUDo

Footnotes

  • Conflict of interest: N. Adderley has nothing to disclose.

  • Conflict of interest: C.J. Humphreys has nothing to disclose.

  • Conflict of interest: H. Barnes has nothing to disclose.

  • Conflict of interest: Z.A. Premji has nothing to disclose.

  • Conflict of interest: K.A. Johannson reports personal fees for advisory board work and lectures, non-financial support and other from Boehringer Ingelheim, personal fees for lectures from Hoffman-La Roche Ltd, grants from The Chest Foundation, University of Calgary Cumming School of Medicine, UCB Biopharma SPRL and Pulmonary Fibrosis Society of Calgary, personal fees for consultancy from Blade Therapeutics and Theravance, personal fees for consultancy and non-financial support from Three Lakes Foundation, outside the submitted work.

  • Received January 12, 2021.
  • Accepted January 19, 2021.
  • ©The authors 2021. For reproduction rights and permissions contact permissions{at}ersnet.org
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European Respiratory Journal: 57 (2)
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Reply: BAL lymphocyte percentage is as good as the company it keeps
Nicola Adderley, Christopher J. Humphreys, Hayley Barnes, Zahra A. Premji, Kerri A. Johannson
European Respiratory Journal Feb 2021, 57 (2) 2100092; DOI: 10.1183/13993003.00092-2021

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Reply: BAL lymphocyte percentage is as good as the company it keeps
Nicola Adderley, Christopher J. Humphreys, Hayley Barnes, Zahra A. Premji, Kerri A. Johannson
European Respiratory Journal Feb 2021, 57 (2) 2100092; DOI: 10.1183/13993003.00092-2021
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