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Current smoking status is associated with reduced sputum immunoglobulin M and G expression in COPD

Steven P. Cass, Yuqiong Yang, Jing Xiao, Joshua J.C. McGrath, Matthew F. Fantauzzi, Danya Thayaparan, Fengyan Wang, Zhenyu Liang, Fei Long, Christopher S. Stevenson, Rongchang Chen, Martin R. Stampfli
European Respiratory Journal 2021 57: 1902338; DOI: 10.1183/13993003.02338-2019
Steven P. Cass
1Medical Sciences Graduate Program, McMaster University, Hamilton, ON, Canada
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Yuqiong Yang
2State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. China
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Jing Xiao
3State Key Laboratory of Respiratory Disease, Sino-French Hoffmann Institute, College of Basic Medical Science, Guangzhou Medical University, Guangzhou, P.R. China
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Joshua J.C. McGrath
1Medical Sciences Graduate Program, McMaster University, Hamilton, ON, Canada
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Matthew F. Fantauzzi
1Medical Sciences Graduate Program, McMaster University, Hamilton, ON, Canada
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Danya Thayaparan
1Medical Sciences Graduate Program, McMaster University, Hamilton, ON, Canada
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Fengyan Wang
3State Key Laboratory of Respiratory Disease, Sino-French Hoffmann Institute, College of Basic Medical Science, Guangzhou Medical University, Guangzhou, P.R. China
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Zhenyu Liang
2State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. China
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Fei Long
3State Key Laboratory of Respiratory Disease, Sino-French Hoffmann Institute, College of Basic Medical Science, Guangzhou Medical University, Guangzhou, P.R. China
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Christopher S. Stevenson
4Janssen Disease Interception Accelerator, Janssen Pharmaceutical Companies of Johnson and Johnson, Raritan, NJ, USA
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Rongchang Chen
2State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. China
5Shenzhen Institute of Respiratory Diseases, Shenzhen People's Hospital, Shenzhen, P.R. China
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Martin R. Stampfli
2State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. China
6Dept of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada
7Dept of Medicine, Firestone Institute of Respiratory Health at St. Joseph's Health Care, McMaster University, Hamilton, ON, Canada
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Extract

The relationship between smoking status and total immunoglobulin levels in patients with COPD is not fully understood. Decreased immunoglobulin levels have been observed in patients with COPD [1–4], a disease largely attributed to current or former smoking, and cigarette smokers [5, 6]. These studies focused predominately on serum (systemic) or salivary (upper respiratory tract) immunoglobulins. Levels of immunoglobulins in induced sputum, a more direct measure of airway immunoglobulins, are less well studied. Given the vital role immunoglobulins perform in microbial defence and tissue homeostasis, we assessed airway immunoglobulins in induced sputum of smokers and patients with COPD.

Abstract

Current smoking status in subjects with mild to moderate COPD was associated with reduced total induced sputum IgM and IgG. This reduction in immunoglobulins was independent of inhaled corticosteroid use. https://bit.ly/2FtBg1t

Footnotes

  • This study is registered at clinicaltrials.gov with identifiers NCT01274507 and NCT03240315.

  • Conflict of interest: S.P. Cass has nothing to disclose.

  • Conflict of interest: Y. Yang has nothing to disclose.

  • Conflict of interest: J. Xiao has nothing to disclose.

  • Conflict of interest: J.J.C. McGrath has nothing to disclose.

  • Conflict of interest: M.F. Fantauzzi has nothing to disclose.

  • Conflict of interest: D. Thayaparan has nothing to disclose.

  • Conflict of interest: F. Wang has nothing to disclose.

  • Conflict of interest: Z. Liang has nothing to disclose.

  • Conflict of interest: F. Long has nothing to disclose.

  • Conflict of interest: C.S. Stevenson is an employee of Johnson & Johnson.

  • Conflict of interest: R. Chen has nothing to disclose.

  • Conflict of interest: M.R. Stampfli reports grants from Canadian Institutes of Health Research and RespiVert Ltd, part of Janssen Pharmaceuticals, during the conduct of the study; grants from RespiVert Ltd, part of Janssen Pharmaceuticals, personal fees from AstraZeneca and Boehringer Ingelheim, outside the submitted work.

  • Support statement: This study was supported in part by the Canadian Institutes of Health Research (PJT-159792), RespiVert Ltd, part of Janssen Pharmaceuticals, National Key R&D Program of China (2017YFC1310600), Guangzhou Healthcare Collaborative Innovation Major Project (201604020012) and Medical Scientific Research Foundation of Guangdong Province (C2017050). Funding information for this article has been deposited with the Crossref Funder Registry.

  • Received December 20, 2019.
  • Accepted August 13, 2020.
  • Copyright ©ERS 2021
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Current smoking status is associated with reduced sputum immunoglobulin M and G expression in COPD
Steven P. Cass, Yuqiong Yang, Jing Xiao, Joshua J.C. McGrath, Matthew F. Fantauzzi, Danya Thayaparan, Fengyan Wang, Zhenyu Liang, Fei Long, Christopher S. Stevenson, Rongchang Chen, Martin R. Stampfli
European Respiratory Journal Feb 2021, 57 (2) 1902338; DOI: 10.1183/13993003.02338-2019

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Current smoking status is associated with reduced sputum immunoglobulin M and G expression in COPD
Steven P. Cass, Yuqiong Yang, Jing Xiao, Joshua J.C. McGrath, Matthew F. Fantauzzi, Danya Thayaparan, Fengyan Wang, Zhenyu Liang, Fei Long, Christopher S. Stevenson, Rongchang Chen, Martin R. Stampfli
European Respiratory Journal Feb 2021, 57 (2) 1902338; DOI: 10.1183/13993003.02338-2019
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