5Dept of Epidemiology and Biostatistics, School of Public Health, St Mary's Hospital, Imperial College London, London, UK
6Clinical Pharmacology and Therapeutics Section, Institute of Medical and Biomedical Education and Institute for Infection and Immunity, St George's, University of London, London, UK
7Clinical Pharmacology Group, Pharmacy and Medicines Directorate, St George's University Hospitals NHS Foundation Trust, London, UK
8Novo Nordisk Research Centre Oxford, Old Road Campus, Oxford, UK