Abstract
Introduction: Idiopathic Pulmonary Fibrosis (IPF) represents a chronic lung disease with limited clinically applicable biomarkers.
Aim: To investigate differences in parameters of IPF severity based on subgroups of monocyte count and red cell distribution width (RDW) at baseline.
Methods: Treatment-naïve patients with IPF were prospectively enrolled in the study between 1/11/2018 and 14/02/2020 . Monocyte count and RDW at baseline were recorded.
Results: Five hundred four patients (n=504) from two different cohorts (derivation cohort: n=315, validation cohort: n=189) were enrolled [derivation cohort: 266 males, median age: 73 years (95% CI: 72.0-75.0), median FVC%pred: 76.8 (95% CI: 75.0- 79.0), median DLCO%pred: 49.6 (95%CI: 46.2- 52.0), median monocyte count: 0.6 K/μL (95% CI: 0.58-62), median RDW: 14.1 (95% CI: 13.9-14.3)]. Patients with monocyte count>0.6 K/μL had lower FVC%pred [median: 75.0, (95% CI: 72.9-76.0), vs. 80.1, (95% CI: 76.7-82.0), p= 0.02)] and DLCO%pred [median: 46.0, (95% CI: 44.3-52.0) vs. 51.5, (95% CI: 48.0-55.3), p=0.03] compared to patients with monocyte count<0.6 K/μL, respectively. Patients with RDW>14.1 had significantly lower DLCO%pred [median: 46.0, (95% CI: 44.1-51.0) vs. 52.0, (95% CI: 48.0-55.1), p=0.04]. Cut-off levels of the derivation cohort were applied to the validation cohort with similar discriminatory value, as indicated by significant differences in median DLCO%pred between patients with high versus low monocyte count [median: 37.8 vs 45.3, p=0.002], and RDW [37.8 vs 45.3, p=0.005], respectively.
Conclusion: Increased monocyte count and RDW may represent negative prognosticators in patients with IPF.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 720.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020