Abstract
Introduction: Changes in tissue microcirculation play an important role in the pathogenesis of bronchial asthma (BA) Aim: To investigate the state of microcirculation in children with BA using laser Doppler flowmetry (LDF) and laser fluorescence spectroscopy (LFS), to reveal the characteristic changes at various stages of the disease course and against the background of the therapy
Methods: We examined 132 children aged 6-18 y.o.The main group included children with BA(n=102) in a different period of the disease and control group(n=30).The main group included children with mild(n =43), moderate(n=39) and severe(n=20) BA in a different period of disease
Results: Initially significant disorders of microcirculation were detected in patients with moderate BA (M=20.15±0.66 perf.united) compared to the control group (M=25.8±2.67 perf.edunit).After 6 months it was rewiewed that minor changes in the microcirculation index (MI) (23.98±1.05) persist after 3-4 weeks in 23% and normalize after 3-6 months in children with mild asthma.In moderate asthma, MI (21.15±0.66) were maintained after 3-4 weeks in 57% and were normalized slower, while it’s persisted after 6 months in 25% of children. In severe BA a decrease of the MI (18.79 ±1.93) was noted.MI doesn`t recover after 6 months of observation in 2/3 patients. We found a statistically significant decrease in NADH levels in children with acute BA (151,6± 30,15) compared to the control group (286,8±38,2) and this changes can be a criterion for evaluating hypoxia in tissues
Conclusions: Disorders of microcirculation may indicate the severity of the course of asthma, the severity of the exacerbation and the effectiveness of the therapy
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 680.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020