Abstract
Introduction: Asthma, overweight (OW) and obesity (O) are risk factors for sleep disordered breathing (SDB). OW, O and SDB can negatively impact the evolution of asthma.
Objective: Describe the relationship between OW, O, and SDB and clinical, functional, and inflammatory status in asthmatic children.
Materials and Methods: Descriptive cross-sectional study. Children with asthma >5 years old carried out by Hospital de Clínicas's Section of Pediatric Pulmonology has been included. OW or O were determined according to Z score and SDB according to the Pediatric Sleep Questionnaire (PSQ ≥0,33). In all cases asthma severity was defined by the treatment step (GINA). Asthma Control Test (ACT), spirometry and Exhaled Nitric Oxide Fraction (FENO) were measured.
Results: 94 asthmatic children, 41 f (44%), mean age 10.5 years (SD ±2.87), 53 OW (56%), 1 O. 38 SDB (40%; PSQ median 0,52). Coexistence of OW and SDB in 39% of the OW (21/53) and SDB in the only O was found. 26 children (28%) did not present OW, O, or SDB. The frequency of obstructive spirometry (VEF1/FVC index < 85%) was higher in OW-O children (p 0.005). SDB was associated with greater frequency of severe asthma (p 0,000), poorly controlled asthma (ACT ≤19) and lower ACT score (19 ± 4 vs 24 ± 2, p 0.000). Patients with SDB associated with OW-O had lower FEV1/FVC index (79 ± 2 vs 85 ± 2 p 0.000) and lower FENO (33 ± 5 ppb vs 58 ± 16 ppb, p 0.04) than children with normal weight.
Conclusion: OW-O are associated with greater obstruction in spirometry and SDB is associated with worse clinical state. SDB plus OW-O was associated with lower eosinophilic inflammation.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 671.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020