Abstract
Background: FRI is a non-invasive quantitative imaging methodology that provides detailed measurements of the lungs and airways. FRI uses HRCT scans and quantitative imaging technology based on computational fluid dynamics (CFD) to model airflow in the respiratory system and provide quantifiable measures of drug deposition.
Aims: To use FRI to determine the deposition patterns for revefenacin administered via a Pari LC® Sprint® Nebulizer (Neb) and tiotropium administered using the Handihaler® dry powder inhaler (DPI).
Methods: 10 COPD subjects in silico (5 males, 5 females; age: 64.7; height: 169 cm; FEV1: 41% predicted) were examined. CFD simulations examined particles past the inhaler: Oropharynx, trachea, extrathoracic and intrathoracic airways including central (>1-2mm, 7-10th generation) and peripheral (<1-2mm, >10th generation). Particle characteristics were taken from published literature.
Results: Intrathoracic and peripheral deposition for Neb was 3-fold higher than the DPI device (34.6% ± 8.53 vs. 10.9% ± 5.67 of delivered dose) and (18.2% ± 4.30 vs. 5.8% ± 2.73 of delivered dose) respectively. The central-to-peripheral (C/P) ratio of the nebulizer is very similar to the DPI, even though the MMAD is higher. C/P ratio decreased after bronchodilation, suggesting better deposition in the peripheral region during neb delivery.
Conclusions: FRI data suggest more efficient intrathoracic and peripheral drug deposition from a standard jet nebulizer than a Handihaler® DPI. FRI imaging supports using nebulized bronchodilators for those patients who cannot optimally use a DPI or those who remain symptomatic.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 637.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020