Abstract
Background: Prematurely born infants, particularly those who develop bronchopulmonary dysplasia (BPD) in the neonatal period, are a growing group of subjects at-risk of developing early-onset COPD.
Aim: To identify metabolic dysregulations associated with BPD.
Methods: The LUNAPRE cohort (n=96; www.clinicaltrials.gov/ct2/show/NCT02923648) consists of 4 non-smoking groups, age 18-23 years: i) prematurely born (<32weeks of gestation) BPD survivors (n=26); ii) healthy born preterm (<32 weeks, n=23), iii) healthy born at term (>37 weeks, n=24), and iv) mild asthmatics born at term (>37 weeks, n=23). Urinary metabolomics was performed using high-resolution mass spectrometry in combination with targeted quantification of the urinary eicosanoid profiles. Data were analyzed using univariate and multivariate statistics.
Results: Metabolomics identified 232 urinary metabolites, of which 93 were standard-confirmed. Urinary metabolic profiles were dysregulated in healthy pre-term individuals vs. BPD survivors in males (CV-ANOVA p=0.006), but not females (CV-ANOVA p=0.24). Multivariate analysis found that urinary eicosanoid profiles differed between the BPD survivor group relative to both the healthy pre-term group (p=0.007) and the asthma group (p=0.02). The separation with both groups was primarily driven by downregulation of the thromboxane and prostaglandin D2 pathways.
Conclusions: These preliminary analyses suggest that molecular signatures associated with BPD and birth-term are sex-specific, persist into adulthood and may be useful for understanding this unique sub-group of COPD patients.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 5246.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020