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Clinical phenotypes of exacerbation are associated with differences in microbial composition and diversity in COPD

Holly Rachael Keir, Alison Dicker, Mike Lonergan, Megan Crichton, Bruce Miller, Ruth Tal Singer, James D Chalmers
European Respiratory Journal 2020 56: 4931; DOI: 10.1183/13993003.congress-2020.4931
Holly Rachael Keir
1Scottish Centre for Respiratory Research,University of Dundee, Dundee, United Kingdom
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  • For correspondence: r.h.z.keir@dundee.ac.uk
Alison Dicker
2Scottish Centre for Respiratory Research,University of Dundee, Dundeegus), United Kingdom
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Mike Lonergan
3Scottish Centre for Respiratory Research,University of Dundee, DundeeAngus), United Kingdom
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Megan Crichton
1Scottish Centre for Respiratory Research,University of Dundee, Dundee, United Kingdom
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Bruce Miller
4Medical Innovation, GSK Pharmaceuticals R&D, Collegeville, United States of America
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Ruth Tal Singer
4Medical Innovation, GSK Pharmaceuticals R&D, Collegeville, United States of America
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James D Chalmers
1Scottish Centre for Respiratory Research,University of Dundee, Dundee, United Kingdom
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    Figure 1

    A: PCoA clustering of stable and exacerbation samples. B: LEfSe Blue=more abundant in stable, Red=more abundant in exacerbation samples. C: PCoA 0=stable, 1=bacterial, 2=eosinophilic 3=viral. D: Shannon diversity between groups.

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Clinical phenotypes of exacerbation are associated with differences in microbial composition and diversity in COPD
Holly Rachael Keir, Alison Dicker, Mike Lonergan, Megan Crichton, Bruce Miller, Ruth Tal Singer, James D Chalmers
European Respiratory Journal Sep 2020, 56 (suppl 64) 4931; DOI: 10.1183/13993003.congress-2020.4931

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Clinical phenotypes of exacerbation are associated with differences in microbial composition and diversity in COPD
Holly Rachael Keir, Alison Dicker, Mike Lonergan, Megan Crichton, Bruce Miller, Ruth Tal Singer, James D Chalmers
European Respiratory Journal Sep 2020, 56 (suppl 64) 4931; DOI: 10.1183/13993003.congress-2020.4931
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More in this TOC Section

  • R. mucilaginosa is an anti-inflammatory in chronic lung disease
  • IMMUNOSUPPRESSANTS AND THE PROGNOSIS OF SARS-COV-2 INFECTION
  • M. PNEUMONIAE CARRIAGE EVADES INDUCTION OF MUCOSAL ANTIBODIES
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