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Late Breaking Abstract - The burden of pertussis in adults with asthma: a retrospective database study in England

Emmanuel Aris, Esse Ifebi Akpo, Amit Bhavsar, Lauriane Harrington, Evie Merinopoulou, Nicola Sawalhi-Leckenby, Elisa Turriani, Kinga Meszaros, Dimitra Lambrelli, Piyali Mukherjee
European Respiratory Journal 2020 56: 4926; DOI: 10.1183/13993003.congress-2020.4926
Emmanuel Aris
1GSK, Wavre, Belgium
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  • For correspondence: emmanuel.x.aris@gsk.com
Esse Ifebi Akpo
1GSK, Wavre, Belgium
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Amit Bhavsar
1GSK, Wavre, Belgium
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Lauriane Harrington
1GSK, Wavre, Belgium
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Evie Merinopoulou
2Evidera Ltd, London, United Kingdom
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Nicola Sawalhi-Leckenby
2Evidera Ltd, London, United Kingdom
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Elisa Turriani
1GSK, Wavre, Belgium
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Kinga Meszaros
1GSK, Wavre, Belgium
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Dimitra Lambrelli
2Evidera Ltd, London, United Kingdom
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Piyali Mukherjee
1GSK, Wavre, Belgium
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Abstract

Introduction: Pertussis is under-recognized in older adults, especially those with chronic conditions like asthma. It is important to estimate the incidence and economic burden of pertussis in these populations.

Objectives: To estimate the burden of reported pertussis cases among ≥50-year-olds (≥50yo) and in an asthma sub-population (≥50yo+Asthma) in England, 2009-18.

Methods: A retrospective observational study was conducted using the Clinical Practice Research Datalink, GOLD and Aurum databases, linked to Hospital Episode Statistics. Occurrence of pertussis and asthma were identified by diagnostic codes. Incidence rates (IRs) of pertussis among ≥50yo and ≥50yo+Asthma cohorts were estimated. Healthcare resource utilization will be presented in the poster.

Results: Among ≥50yo, 28.5 million (m) person-years follow-up (PYFU) were included, with 3.6m PYFU ≥50yo+Asthma. Across the study period, IRs of pertussis were statistically higher in ≥50yo+Asthma than the ≥50yo cohort (9.61 (95% CI: 8.63-10.68) and 5.76 (5.48-6.04) /100,000 PYFU, respectively), with point estimates consistently higher over time. Observed IRs decreased with age in both groups.

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Conclusions: The incidence of diagnosed pertussis was higher among ≥50yo+Asthma patients than the ≥50yo cohort. Considering other literature suggesting under-diagnosis of pertussis, further research is warranted on the potential health and economic impact of pertussis in asthmatics.

  • Chronic diseases
  • Asthma
  • Adults

Footnotes

Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4926.

This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2020
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Late Breaking Abstract - The burden of pertussis in adults with asthma: a retrospective database study in England
Emmanuel Aris, Esse Ifebi Akpo, Amit Bhavsar, Lauriane Harrington, Evie Merinopoulou, Nicola Sawalhi-Leckenby, Elisa Turriani, Kinga Meszaros, Dimitra Lambrelli, Piyali Mukherjee
European Respiratory Journal Sep 2020, 56 (suppl 64) 4926; DOI: 10.1183/13993003.congress-2020.4926

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Late Breaking Abstract - The burden of pertussis in adults with asthma: a retrospective database study in England
Emmanuel Aris, Esse Ifebi Akpo, Amit Bhavsar, Lauriane Harrington, Evie Merinopoulou, Nicola Sawalhi-Leckenby, Elisa Turriani, Kinga Meszaros, Dimitra Lambrelli, Piyali Mukherjee
European Respiratory Journal Sep 2020, 56 (suppl 64) 4926; DOI: 10.1183/13993003.congress-2020.4926
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