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Collagen and elastin turnover increase at COPD exacerbation irrespectively its etiology

Eleni Papakonstantinou, Jannie Sand, Leticia Grize, Hans Hirsch, Michael Tamm, Morten Karsdal, Daiana Stolz
European Respiratory Journal 2020 56: 4720; DOI: 10.1183/13993003.congress-2020.4720
Eleni Papakonstantinou
1Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital of Basel; Department of Biomedicine, University of Basel, Basel, Switzerland
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  • For correspondence: epap@med.auth.gr
Jannie Sand
2Nordic Bioscience, Biomarkers and Research, Herlev, Denmark
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Leticia Grize
3Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital of Basel, Basel, Switzerland
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Hans Hirsch
4Department of Biomedicine, University of Basel, Basel, Switzerland
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Michael Tamm
1Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital of Basel; Department of Biomedicine, University of Basel, Basel, Switzerland
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Morten Karsdal
2Nordic Bioscience, Biomarkers and Research, Herlev, Denmark
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Daiana Stolz
1Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital of Basel; Department of Biomedicine, University of Basel, Basel, Switzerland
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Abstract

Extracellular matrix (ECM) fragments serve as surrogate markers of disease activity in COPD. Respiratory infections have been implicated as the predominant risk factor for acute exacerbations of COPD (AECOPD).

We aimed to assess if serum levels of collagen and elastin turnover products are associated with the etiology of AECOPD.

Pro-forms of collagens III (PRO-C3), V (PRO-C5), VI (PRO-C6), degradation products of collagens I (C1M), III (C3M), IV (C4Ma3), VI (C6M) and neutrophil elastase-generated fragments of elastin (EL-NE) were measured in serum of the PREVENT study, an investigator-initiated and driven, controlled trial, with 450 COPD patients, GOLD II-IV, followed for 3 years. Out of 2833 visits, we included AECOPD visits without infection in the last stable visit (n=102) and categorised them according to etiology; no new infection (n=22); viral infections (n=23); bacterial infections (n=37); viral and bacterial infections (n=20). Multiplex PCR was used to monitor viral infections in laryngopharyngeal swabs and microbiological analysis was performed in sputum samples in all visits.

C1M, C3M, C4Ma3, C6M, EL-NE and PRO-C5 levels were significantly higher at AECOPD, as compared to previous stable visits (p<0.001 for all) and to follow-up visits (p<0.001 for all). Changes in serum levels of all biomarkers between last stable visit, AECOPD and follow-up were comparable and not associated with the presence or the type of infection. C1M, C3M, C4Ma3 and C6M were positively correlated with SGQ, CAT and MMRC scores and PRO-C6 and PRO-C3 with lung function.

These results indicate that systemic biomarkers of collagen and elastin turnover increase at AECOPD irrespectively the etiology of exacerbation.

  • COPD
  • COPD - mechanism
  • COPD - exacerbations

Footnotes

Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4720.

This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2020
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Collagen and elastin turnover increase at COPD exacerbation irrespectively its etiology
Eleni Papakonstantinou, Jannie Sand, Leticia Grize, Hans Hirsch, Michael Tamm, Morten Karsdal, Daiana Stolz
European Respiratory Journal Sep 2020, 56 (suppl 64) 4720; DOI: 10.1183/13993003.congress-2020.4720

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Collagen and elastin turnover increase at COPD exacerbation irrespectively its etiology
Eleni Papakonstantinou, Jannie Sand, Leticia Grize, Hans Hirsch, Michael Tamm, Morten Karsdal, Daiana Stolz
European Respiratory Journal Sep 2020, 56 (suppl 64) 4720; DOI: 10.1183/13993003.congress-2020.4720
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