Abstract
Objective: To evaluate the association between DM duration and the incidence of TB in general population.
Methods: We identified 6,312,283 subjects who are free of TB until one year after the day of their health examination (2009) and were followed up until December 31, 2018 using the database of the Korean National Health Insurance Service. Cox proportional hazard regression was used to assess adjusted hazard ratios (aHR) of DM status for TB with adjustment for potential confounders.
Results: A total of 30,917 individuals were diagnosed with TB during follow-up period. An increased risk of TB incidence was observed in DM subjects compared to non-DM subjects (aHR 1.49, 95% confidence interval [CI] 1.45-1.53). While subjects with impaired fasting glucose showed a decreased risk of TB incidence (aHR 0.96, 95% CI 0.93-0.98), the risk of TB incidence was increased with as the duration of DM increased (aHR 1.32, 95% CI 1.25-1.40 in the new-onset DM; aHR 1.46, 95% CI 1.39-1.53 in the DM with duration < 5 years; aHR 1.54, 95% CI 1.48-1.60 in the DM with duration ≥ 5 years). Among non-DM subjects, a U-shaped association was noted between fasting glucose concentrations and the risk of TB.
Conclusions: DM status was an independent predictor for developing TB with a dose-response relationship. In non-DM subjects, there was a U-shaped association between fasting glucose concentrations and TB risk, suggestive of protective role of BMI on TB in non-DM subjects.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4596.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020