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A First Look at the Italian Registry on Pulmonary Non-Tuberculous Mycobacteria (NTM) -IRENE

Stefano Aliberti, Maura Spotti, Giovanni Sotgiu, Maurizio Ferrarese, Paola Francesca Castellotti, Andrea Gramegna, Marina Tadolini, Jessica Mencarini, Gina Gualano, Stefania Cerri, Giuliano Montemurro, Giulia Gardini, Andrea Calcagno, Federico Dente, Michele Trezzi, Paola Faverio, Mario Malerba, Giulia Cucchetto, Enrico Tortoli, Mehdi Mirsaeidi, Antonella Previdi, Andrea Gori, Luigi Ruffo Codecasa, Francesco Blasi On Behalf Of The Irene Network
European Respiratory Journal 2020 56: 4344; DOI: 10.1183/13993003.congress-2020.4344
Stefano Aliberti
1University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
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  • For correspondence: stefano.aliberti@unimi.it
Maura Spotti
1University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
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Giovanni Sotgiu
2Clinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy
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Maurizio Ferrarese
3Regional TB Reference Centre, Villa Marelli Institute/ASST Niguarda, Milano, Italy
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Paola Francesca Castellotti
3Regional TB Reference Centre, Villa Marelli Institute/ASST Niguarda, Milano, Italy
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Andrea Gramegna
1University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
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Marina Tadolini
4Unit of Infectious Diseases, Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy
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Jessica Mencarini
5Azienda Ospedaliero Universitaria Careggi, Dipartimento Medicina Sperimentale e Clinica, SOD Malattie Infettive e Tropicali, Firenze, Italy
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Gina Gualano
6Istituto Nazionale per le Malattie Infettive "L. Spallanzani" – IRCCS UOC Malattie Infettive dell’Apparato Respiratorio, Roma, Italy
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Stefania Cerri
7Azienda Ospedaliero Universitaria Policlinico di Modena, Clinica Malattie Apparato Respiratorio, Modena, Italy
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Giuliano Montemurro
8Fondazione Policlinico Universitario “Agostino Gemelli”, Struttura Complessa Pneumologia, Roma, Italy
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Giulia Gardini
9ASST degli Spedali Civili di Brescia, U.O.C. Malattie Infettive 2, Brescia, Italy
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Andrea Calcagno
10Unit of Infectious Diseases, Department of Medical Sciences, University of Torino, Torino, Italy
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Federico Dente
11Azienda Ospedaliero Universitaria Pisana, Dipartimento di fisiopatologia respiratoria e riabilitazione respiratoria, Pisa, Italy
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Michele Trezzi
12AUSL Toscana Centro, S.O.C. Malattie Infettive II, , Pistoia, Italy
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Paola Faverio
13ASST di Monza, Ospedale San Gerardo, U.O. Pneumologia, Monza, Italy
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Mario Malerba
14Ospedale "S. Andrea", Struttura complessa di Pneumologia, Vercelli, Italy
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Giulia Cucchetto
15Azienda Ospedaliera Universitaria Integrata di Verona, Centro Fibrosi Cistica, Verona, Italy
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Enrico Tortoli
16Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy
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Mehdi Mirsaeidi
17Division of Pulmonary and Critical Care Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Section of Pulmonary Medicine, Miami Veterans Affairs Healthcare System,, Miami, United States of America
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Antonella Previdi
18AMANTUM -Associazione Nazionale Malati da NTM, Milano, Italy
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Andrea Gori
1University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
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Luigi Ruffo Codecasa
3Regional TB Reference Centre, Villa Marelli Institute/ASST Niguarda, Milano, Italy
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Francesco Blasi
1University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
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Abstract

Data on characteristics of patients with pulmonary NTM in Italy are lacking. The Italian Registry on pulmonary NTM (IRENE) has been set up in April 2017 as a multicenter, prospective, observational, cohort study enrolling consecutive adults with active NTM pulmonary infection or NTM pulmonary disease (NTM-PD) from 48 centers across Italy. Data are collected at baseline with yearly follow-up visits. 500 patients have been enrolled in the registry so far. Median (IQR) age is 67 (55-75) years, 66% are females, median (IQR) BMI is 20 (18-22), and 45% are current/former smokers. 90% have pre-existing lung diseases, including bronchiectasis (66%), COPD (21%), cystic fibrosis (10%) and asthma (8%), 36% have GERD, and 25% at least one risk factor for immunosuppression. 355 (71%) patients met the 2007 ATS/IDSA criteria for NTM-PD. Among them, the most common NTM are M. avium complex (72%) -including M. intracellulare (28%) and M. avium (27%)-, M. abscessus complex (MABc) (13%) -including M. a.abscessus (10%)-, M. xenopi (4%) and M. kansasii (3%). 77% of the patients have cough, 55% sputum production, 51% fatigue, 47% shortness of breath, 37% weight loss, 27% intermittent fever, 26% haemoptysis, and 22% night sweats. In terms of radiology, 21% of the patients have cavitating nodules, 13% large cavities and 58% consolidations. Median (IQR) FEV1%pred. is 77% (59-94). A total of 77% of patients with NTM-PD underwent treatment, including azithromycin/clarithromycin, ethambutol, rifampicin/rifabutin. IRENE has the important role to inform the clinical and scientific communities on the current management of adults with pulmonary NTM in Italy and acts as a national network to increase disease awareness.

  • Chronic diseases

Footnotes

Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4344.

This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2020
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A First Look at the Italian Registry on Pulmonary Non-Tuberculous Mycobacteria (NTM) -IRENE
Stefano Aliberti, Maura Spotti, Giovanni Sotgiu, Maurizio Ferrarese, Paola Francesca Castellotti, Andrea Gramegna, Marina Tadolini, Jessica Mencarini, Gina Gualano, Stefania Cerri, Giuliano Montemurro, Giulia Gardini, Andrea Calcagno, Federico Dente, Michele Trezzi, Paola Faverio, Mario Malerba, Giulia Cucchetto, Enrico Tortoli, Mehdi Mirsaeidi, Antonella Previdi, Andrea Gori, Luigi Ruffo Codecasa, Francesco Blasi
European Respiratory Journal Sep 2020, 56 (suppl 64) 4344; DOI: 10.1183/13993003.congress-2020.4344

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A First Look at the Italian Registry on Pulmonary Non-Tuberculous Mycobacteria (NTM) -IRENE
Stefano Aliberti, Maura Spotti, Giovanni Sotgiu, Maurizio Ferrarese, Paola Francesca Castellotti, Andrea Gramegna, Marina Tadolini, Jessica Mencarini, Gina Gualano, Stefania Cerri, Giuliano Montemurro, Giulia Gardini, Andrea Calcagno, Federico Dente, Michele Trezzi, Paola Faverio, Mario Malerba, Giulia Cucchetto, Enrico Tortoli, Mehdi Mirsaeidi, Antonella Previdi, Andrea Gori, Luigi Ruffo Codecasa, Francesco Blasi
European Respiratory Journal Sep 2020, 56 (suppl 64) 4344; DOI: 10.1183/13993003.congress-2020.4344
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