Abstract
Available normal lung function curves are derived from cross-sectional data or from longitudinal data of subjects followed for a short period. We derived FEV1, FVC and FEV1/FVC curves over the life-course using longitudinal data from three population-based birth and adult cohorts, according to asthma, smoking and obesity status.
We included 26,378 subjects with spirometry, body mass index (BMI), asthma and smoking at ≥2 time points, from ALSPAC-UK, ECRHS-12 EU countries & Australia, and SAPALDIA-Switzerland in an accelerated cohort design. We built multi-level mixed models with random effects on subjects and 5-y birth range cohorts; sex, asthma, BMI and smoking; and interaction terms for quadratic age and BMI, asthma and smoking. We stratified analysis by 'persistent, varying, never' for asthma, smoking and obesity (z-BMI>95th perc).
Raw FEV1 and FVC increased up to a short plateau ≈20 y and then declined; FEV1/FVC declined from early life (Fig 1). Persistent asthma (7%) related to low FEV1, FVC and FEV1/FVC at all ages; persistent smoking (26%) to excess decline in FEV1, FVC and FEV1/FVC from ≈40 y; and persistent obesity (11%) to excess FEV1 decline from 20 y, higher FVC (and lower ratio) at young ages and excess FVC decline (and higher ratio) in adulthood.
Asthma relates to lower lung function over the life-course while obesity and smoking influence lung function decline.
Method: ALEC, EU H2020 #633212.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4191.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020
