Abstract
Rationale: Increased heterogeneity (coefficient of variation: CV) of dual energy CT (DECT)-derived pulmonary perfused blood volume (PBV), a surrogate for pulmonary perfusion, is reversible with Sildenafil in emphysema-susceptible smokers. We hypothesize that inflammation-associated PBV reduction inhibits repair. Here, we assess PBV-CV in a general population sample at the 6 centers of the Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study.
Methods: Participants were 45-85yrs without clinical cardiovascular disease in 2000-02. Non-contrast full inspiratory CT, iodine-enhanced DECT (functional residual capacity) and spirometry were performed. Voxel-based PBV was calculated by material decomposition, and PBV-CV was assessed for each of 60x60x40 regions comprising the lung field. % emphysema (%emp: voxels <-950HU) was assessed on non-contrast CTs. Generalized linear regression adjusted for age, sex, race/ethnicity, height, weight, cigarette smoking status, pack-years, site, & education.
Results: Valid PBV-CV measures were available for 686 participants (mean age, 71 (range: 59-94)); 45% female, 39% White, 29% Black; 18% Hispanic and 14% Asian; 50% ever smokers. Mean PBV-CV was 65% (SD 4%). PBV-CV showed no sex differences, minor race/ethnicity differences and a positive correlation with age (p<.001). In adjusted analyses, PBV-CV was inversely correlated to FEV1 (p<.001) for participants with %emp > upper-limit-of-normal and was inversely correlated to FEV1/FVC (p<.001). PBV-CV was positively associated with %emp (p<.001).
Conclusions: These data demonstrate the significant relationships between pulmonary circulation status, population characteristics and hallmarks of smoking-associated lung disease.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4187.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020