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Late Breaking Abstract - External validation of exhaled-breath analysis to detect non-small cell lung cancer: a step-wise design to simultaneously develop and validate a prediction model

Sharina Kort, Marjolein Brusse-Keizer, Jan-Willem Gerritsen, Hugo Schouwink, Emanuel Citgez, Frans De Jongh, Daiana Stolz, Michel Van Den Heuvel, Wouter Van Geffen, John Van Putten, Lisanne Kastelijn, Ben Van Den Borne, Job Van Der Palen
European Respiratory Journal 2020 56: 4166; DOI: 10.1183/13993003.congress-2020.4166
Sharina Kort
1Medisch Spectrum Twente, Enschede, Netherlands
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  • For correspondence: s.kort@mst.nl
Marjolein Brusse-Keizer
1Medisch Spectrum Twente, Enschede, Netherlands
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Jan-Willem Gerritsen
2The enose Company, Zutphen, Netherlands
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Hugo Schouwink
1Medisch Spectrum Twente, Enschede, Netherlands
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Emanuel Citgez
1Medisch Spectrum Twente, Enschede, Netherlands
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Frans De Jongh
1Medisch Spectrum Twente, Enschede, Netherlands
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Daiana Stolz
3Universität spittal , Basel, Switzerland
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Michel Van Den Heuvel
4Radboud UMC, Nijmegen, Netherlands
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Wouter Van Geffen
5Medisch Centrum Leeuwarden, Leeuwarden, Netherlands
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John Van Putten
6Martini Ziekenhuis, Groningen, Netherlands
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Lisanne Kastelijn
7Antonius Ziekenhuis, Utrecht, Netherlands
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Ben Van Den Borne
8Catharina Ziekenhuis, Eindhoven, Netherlands
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Job Van Der Palen
9Medisch Spectrum Twengte, Enschede, Netherlands
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Abstract

Introduction: Exhaled-breath analysis of volatile organic compounds (VOCs) has shown the potential to detect lung cancer. Reproducibility of prediction models, especially based on artificial intelligence (AI) algorithms is essential. However, external validation is often lacking as this is time-consuming and meanwhile improved AI models often outperform the “older” model, based on a training set. We aim to simultaneously validate and improve a training model to distinguish non-small cell lung cancer (NSCLC) patients from healthy controls based on AI algorithms.

Methods: We obtained exhaled-breath data of > 800 subjects. This new cohort will be used to externally validate our original prediction model to distinguish between NSCLC patients and healthy controls (N=290, AUC-ROC 0.76). In a step-wise design, a set of 50 subjects will be first predicted by the original model, whereupon these data are added to the unblinded data, and a new prediction model will be created based on an increased sample size. This will be repeated 6 times. The remaining 500 subjects will be used to validate the final extended model. Performance will be assessed by Area under the Curve.

Results: Despite finishing the inclusions, due to the COVID pandemic, we have not yet been able to validate data of all included subjects in all 7 centres. This will be done before September 2020.

Conclusion: We propose a design to simultaneously externally validate an original prediction model based on exhaled-breath data to distinguish NSCLC patients from healthy controls and develop new prediction models based on improved AI techniques.

  • Lung cancer - diagnosis
  • Breath test

Footnotes

Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4166.

This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2020
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Late Breaking Abstract - External validation of exhaled-breath analysis to detect non-small cell lung cancer: a step-wise design to simultaneously develop and validate a prediction model
Sharina Kort, Marjolein Brusse-Keizer, Jan-Willem Gerritsen, Hugo Schouwink, Emanuel Citgez, Frans De Jongh, Daiana Stolz, Michel Van Den Heuvel, Wouter Van Geffen, John Van Putten, Lisanne Kastelijn, Ben Van Den Borne, Job Van Der Palen
European Respiratory Journal Sep 2020, 56 (suppl 64) 4166; DOI: 10.1183/13993003.congress-2020.4166

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Late Breaking Abstract - External validation of exhaled-breath analysis to detect non-small cell lung cancer: a step-wise design to simultaneously develop and validate a prediction model
Sharina Kort, Marjolein Brusse-Keizer, Jan-Willem Gerritsen, Hugo Schouwink, Emanuel Citgez, Frans De Jongh, Daiana Stolz, Michel Van Den Heuvel, Wouter Van Geffen, John Van Putten, Lisanne Kastelijn, Ben Van Den Borne, Job Van Der Palen
European Respiratory Journal Sep 2020, 56 (suppl 64) 4166; DOI: 10.1183/13993003.congress-2020.4166
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