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Late Breaking Abstract - Persisting pulmonary impairment following severe SARS-CoV-2 infection, preliminary results from the CovILD study

Sabina Sahanic, Thomas Sonnweber, Alex Pizzini, Gerlig Widmann, Anna Luger, Magdalena Aichner, Anna Böhm, Guenter Weiss, Christoph Tschurtschenthaler, Verena Petzer, David Haschka, Markus Theurl, Daniela Lener, Sophie Wildner, Rosa Bellmann-Weiler, Ewald Wöll, Judith Löffler-Ragg, Ivan Tancevski
European Respiratory Journal 2020 56: 4143; DOI: 10.1183/13993003.congress-2020.4143
Sabina Sahanic
1Department of Internal Medicine II, Pneumology, Innsbruck, Austria
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  • For correspondence: sabina.sahanic@i-med.ac.at
Thomas Sonnweber
1Department of Internal Medicine II, Pneumology, Innsbruck, Austria
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Alex Pizzini
1Department of Internal Medicine II, Pneumology, Innsbruck, Austria
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Gerlig Widmann
2Department of Radiology, Innsbruck, Austria
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Anna Luger
2Department of Radiology, Innsbruck, Austria
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Magdalena Aichner
1Department of Internal Medicine II, Pneumology, Innsbruck, Austria
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Anna Böhm
1Department of Internal Medicine II, Pneumology, Innsbruck, Austria
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Guenter Weiss
1Department of Internal Medicine II, Pneumology, Innsbruck, Austria
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Christoph Tschurtschenthaler
1Department of Internal Medicine II, Pneumology, Innsbruck, Austria
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Verena Petzer
3Department of Internal Medicine V, Innsbruck, Austria
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David Haschka
1Department of Internal Medicine II, Pneumology, Innsbruck, Austria
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Markus Theurl
44Department of Internal Medicine III, Innsbruck, Austria
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Daniela Lener
44Department of Internal Medicine III, Innsbruck, Austria
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Sophie Wildner
1Department of Internal Medicine II, Pneumology, Innsbruck, Austria
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Rosa Bellmann-Weiler
1Department of Internal Medicine II, Pneumology, Innsbruck, Austria
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Ewald Wöll
5St. Vinzenz Hospital, Zams, Austria
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Judith Löffler-Ragg
1Department of Internal Medicine II, Pneumology, Innsbruck, Austria
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Ivan Tancevski
1Department of Internal Medicine II, Pneumology, Innsbruck, Austria
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Abstract

Background: In the 2002/2003 SARS1 outbreak, 30% of survivors exhibited persisting structural pulmonary abnormalities months after infection. Yet to this day, there is no follow-up data in patients after severe COVID-19.

Aims: In this prospective multicentre observational study, we aim to systematically evaluate the cardio-pulmonary damage in COVID-19 survivors at 6, 12, and 24 weeks after discharge.

Methods: At each visit, clinical examination, laboratory testing, blood gas analysis, lung function, thoracic HR-CT and echocardiography are conducted.

Results: Preliminary data from 82 consecutive patients was evaluated at the first follow-up visit, i.e. 6 weeks after discharge. Mean age was 56.7 years (63.4% males); 43.9% of patients had a positive smoking history. 54 patients (65.9%) exhibited persistent symptoms, with dyspnoea ranking highest (36.6%), followed by cough (19.5%). 20 patients (24.4%) showed persistent lung impairment (defined as FVC <80% and/or FEV1 <80%), while 31 patients (37.8%) showed signs of hyperinflation (defined as RV >120%). 23 patients (28%) showed reduced diffusion capacity (DLCO). 48 patients (58.5%) showed left ventricular diastolic dysfunction. Importantly, serum NT-proBNP, D-dimer, and ferritin levels were found significantly elevated.

Conclusion: A major portion of COVID-19 survivors presented with persisting dyspnoea and lung function abnormalities. Altogether, our results indicate prolonged resolution and remodelling, implementation of our HR-CT scan findings will finally be key to exactly define the cardio-pulmonary damage after COVID-19. We are eager to present our data of 6 and 12 weeks follow-ups at the ERS 2020.

  • Viruses
  • Pneumonia
  • Spirometry

Footnotes

Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4143.

This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2020
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Late Breaking Abstract - Persisting pulmonary impairment following severe SARS-CoV-2 infection, preliminary results from the CovILD study
Sabina Sahanic, Thomas Sonnweber, Alex Pizzini, Gerlig Widmann, Anna Luger, Magdalena Aichner, Anna Böhm, Guenter Weiss, Christoph Tschurtschenthaler, Verena Petzer, David Haschka, Markus Theurl, Daniela Lener, Sophie Wildner, Rosa Bellmann-Weiler, Ewald Wöll, Judith Löffler-Ragg, Ivan Tancevski
European Respiratory Journal Sep 2020, 56 (suppl 64) 4143; DOI: 10.1183/13993003.congress-2020.4143

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Late Breaking Abstract - Persisting pulmonary impairment following severe SARS-CoV-2 infection, preliminary results from the CovILD study
Sabina Sahanic, Thomas Sonnweber, Alex Pizzini, Gerlig Widmann, Anna Luger, Magdalena Aichner, Anna Böhm, Guenter Weiss, Christoph Tschurtschenthaler, Verena Petzer, David Haschka, Markus Theurl, Daniela Lener, Sophie Wildner, Rosa Bellmann-Weiler, Ewald Wöll, Judith Löffler-Ragg, Ivan Tancevski
European Respiratory Journal Sep 2020, 56 (suppl 64) 4143; DOI: 10.1183/13993003.congress-2020.4143
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