Abstract
Aims and Objectives: We investigated the impact of stereotactic body radiation therapy (SABR) and video-assisted thoracoscopic (VATS) lung resection on quality of life (QoL) after early stage NSCLC’ treatments.
Methods: In a prospective longitudinal observational study, QoL was assessed through the EORTC QLQ C-30 at baseline, 6 weeks and 3, 6 and 12 months post-treatment. We performed a responder analysis with a distribution-based approach to define the thresholds for clinically meaningful QoL changes.
Results: 130 surgical and 95 SABR patients consented from March 2017 to March 2018. Fig 1 shows the evolution of QoL from baseline to 12 months. At twelve months, SABR patients reported a decline in Role Functioning (from 63.1 to 57, p=0.009) and an increase in Emotional Functioning (from 66.4 to 72.9, p=0.07). Surgical patients experienced a decline in Physical Functioning (from 81.6 to 75.7, p=0.009) and Role Functioning (from 83.3 to 75.3, p= 0.01), and worsening of Dyspnoea (from 27.3 to 38.2, p=0.001). 12 months after SABR 48.8% of patients maintained a stable SumSc (vs. 45.3% after surgery) and 40% their GH (vs. 54.6%). Only 14.5% of surgical patients improved their GH compared to 37.8% of the SABR patients.
Conclusions: Although clinical outcomes are not fully comparable due to differing clinical profiles, the QoL information, will ultimately support decision-making process.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4091.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020
