Abstract
Background: We hypothesised that a proportion of cases of Idiopathic Pulmonary Fibrosis (IPF) are due to occult occupational asbestos exposure.
Aims and Objectives: To investigate the relationship between occupational asbestos exposure, cigarette smoking, and MUC5B rs35705950 genotype with respect to IPF risk.
Methods: Asbestos exposure for 960 participants (494 cases, 466 controls) was assessed using a job exposure matrix (JEM) based on occupational proportional mortality data for pleural mesothelioma and by means of a validated asbestos exposure reconstruction method in a UK multicentre hospital-based case-control study, IPFJES.
Results:
Table 1: Logistic regression of ever smoking and ever being occupationally asbestos exposed (inferred by job title) stratified by MUC5B rs35705950 genotype. Ever being occupationally asbestos exposed was defined as ever having a job that was medium or high risk for asbestos exposure. 1additive model, adjusted for age and smoking. 2analysis limited to genotyped participants (N=818). 3Genotype of MUC5B rs35705950, T is minor allele. Neither smoking or asbestos exposure were significant alone.
Conclusion: In the aetiology of IPF there appears to be an interaction between occupational exposure to asbestos, smoking, and the minor allele of the MUC5B promoter variant rs35705950.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3851.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020