Abstract
Introduction-Aim: Lung clearence index (LCI) is a sensitive test to detect early changes in small airways in cystic fibrosis (CF). The aim of this study is to define the predictive role of initial LCI on FEV1 change and the parameters that effect it.
Methods: LCI was concurrently performed to CF patients who had a %FEV1 value ≥80 and FEV1 change was evaluated prospectively in one year follow up. CF mutation,colonization status,acute pulmonary execerbations, treatments were also assessed during this time.
Results: Mean age was 11,5(±3,5). Mean LCI was 7,01(±2,09). Initial mean spirometric values were: FEV1 z score 0,58(±1,56), FEF25-75 z score 0,18(±1,88). FEV1 z score declined in 3. 6. and 12. month (z score: 0,17 (p:0,03), -0,03(p:<0,001), -0,05(p:<0,001) respectively). LCI was negatively corraleted with first, 3. 6. and 12. month FEV1 and FEF25-75 z scores (FEV1: r:-0,30(p:0,01), r:-0,38 (p:0,01), r:-0,25(p:0,05), r:-0,28 (p:0,02), FEF25-75: r:-0,26(p:0,04), r:-0,35(p:0,02), r:-0,31(p:0,02), r:-0,28 (p:0,006) respectively). LCI value predicting FEV1 decline under %80 at the end of one year was 5,89 (sensitivity %92,8, specificity %36,7).There was no difference in first FEV1, FEF25-75 z score and 12. month in patients who had a LCI value <5,89; whereas FEV1, FEF25-75 z score significantly decreased in one year follow up in patients with LCI ≥5,89. Patients with LCI<5,89 had higher initial FEV1 (p<0,001). FEV1 decline wasn't affected by other factors.
Conclusion: LCI ≥5,89 may be a guide for pulmonary function decline in early stages. Therefore patients with high LCI, even if they have normal spirometric values should be closely and carefully followed.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 357.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020