Abstract
Background: Idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-interstitial lung disease (SSc-ILD) are chronic fibrotic disorders that, despite sharing common profibrotic pathways, display differences in epidemilogy and clinical presentation.
Objective: To investigate features of IPF and SSc-ILD patients admitted to a tertiary pulmonology unit for a recent onset/worsening dyspnea.
Methods: Fourty-one IPF and 39 SSc-ILD patients visited over 1 year were investigated for lung function and comorbidities frequently associated with both conditions.
Results: As expected, SSc-ILD were predominantly females and younger (median 61 vs 73 years old, p<0.0001). IPF patients were more frequently smokers, walked a shorter distance at 6 minute walking test (346 mt vs 423, p=0.02), and more frequently desaturated under effort (17/27 vs 9/29, p=0.03). However, the 2 groups did not significantly differ in % of predicted forced vital capacity (89.24 in SSc-ILD vs 85.03 in IPF) and diffusing lung capacity for CO (51.15 in SSc-ILD vs 54.94 in IPF), and had a similar proportion of previous oxygen therapy (10/39 in SSc-ILD vs 17/41 in IPF). In regard of comorbidities, gastroesophageal reflux was more frequent in SSc-ILD (27/39 vs 13/41, p=0.02), while there was no difference in the proportion of secondary pulmonary hypertension (4/39 in SSc-ILD vs 3/41 in IPF) and history of cancer (2/39 in SSc-ILD vs 5/41 in IPF).
Conclusion: Despite differences in epidemilogical and clinical features, patients with SSc-ILD and IPF share common functional features at presentation.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3547.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020