Abstract
Background: Systemic sclerosis-related interstitial lung disease (SSc-ILD) is the most common cause of death in systemic sclerosis (SSc) patients; hence this should be taken into consideration, and be closely monitored with regular follow-ups. This study aim to identify lung function change and predictors of lung function decline in SSc-ILD.
Methods: : A retrospective study extracted SSc patients from the Electronic database, from January, 2002 to July 2019. Eligible cases included SSc patients aged over 15 years, whom were diagnosed as having SSc-ILD. Factors associated with progressive lung function change were analyzed by univariate and multivariate logistic regression analysis. The statistical analysis utilized R 3.5.2 software.
Results: : 130 SSc-ILD cases were enrolled, and from this 103 (79.2%) patients were female, with the mean age being 45.7+14.8 years, and 89 (68.5%) diffuse SSc-ILD. SSc-ILD patients mainly had crackles and dyspnea on exertion (74.6 and 70.8%, respectively), while 23.1% of SSc-ILD patients had no abnormal respiratory symptom. The most common type was nonspecific interstitial pneumonia (NSIP) (42.3%). FVC, TLC and DLCO during a 12-month follow-up period were slightly stable. For predicting factors of progressive SSc-ILD, male gender and no previous aspirin treatment were two significant predicting factors of progressive SSc-ILD, with adjusted odd ratio 5.72 and 4.99, respectively.
Conclusion: : This study shows stable short-term lung function after a 12-month follow-up. Predicting factors, such as male gender, previous aspirin treatment should be considered for early progressive disease detection. The role of aspirin treatment should also be further investigated.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3543.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020