Abstract
Background: Pulmonary hypertension (PH) is a common complication of bronchopulmonary dysplasia (BPD) in preterm infants. An up-to-date overview of mortality in BPD-PH infants was conducted.
Methods: A systematic literature search of Medline and Embase was conducted including observational studies in paediatric BPD-PH with mortality data.
Results: 25 studies (n=2179 patients) were included, 84% were retrospective, and 76% in North America. PH diagnosis was based on echocardiographic criteria in 96% of the studies. The mortality proportion (MP) ranged from 4.0% to 52.8% (median: 13.0%) with decreasing trend over studies timing (Figure 1). The 2-year survival estimate (n=5 studies) ranged from 35.0% to 80.0% with a steep survival decrease between 6 months and 1 year, then stabilisation (Figure 2). An inverse relation between MP and birthweight reflected the degree of pulmonary and vascular tracts immaturity leading to severe BPD-PH.
Conclusion: Registries with standardised definitions, longer follow-up would be of interest to better estimate mortality, and its direct relationship to BPD-PH in preterm infants.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3502.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020
