Abstract
Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by exposure to organic antigens that cause an immune response mediated by T lymphocytes in susceptible subjects. There is an acute/sub-acute variant and a chronic variant characterized by fibrotic evolution (cHP).
We evaluated functional progression in cHP patients, with a monocentric retrospective observational study.
We enrolled 54 patients, average age at diagnosis: 68 , 12 women. Average follow up: 44 months. Diagnosis made through multidisciplinary evaluation.
The number of average hospitalizations for respiratory causes was 1.6 per patient. Of the 54 patients, 9 died, 4.1 years after diagnosis.
Bronchoscopy: on average, BAL at Neutrophils 7.89%, Lymphocytes 21.26%, Macrophages 66.19%, Eosinophils 1.15%, Basophils 0.00%, and a CD4 / CD8 ratio of 1.49. Chest CT scan: the prevalent lesion in patients was honeycombing (48/54), followed by micronodules (37/54), air trapping (36/54) and traction bronchiectasis (28/54).
cHP represents a severe disease, with a prognosis that can become poor in the short/medium term from diagnosis. These are preliminary data.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3478.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020