Abstract
Background: As of yet, there remains an urgent need for early identification of lung cancer patients who are at increased risk of developing venous thromboembolism (VTE) and should receive prophylactic anticoagulation treatment. We aimed to investigate the value of clinicopathological parameters as predictors of VTE risk in small cell lung cancer (SCLC).
Materials and Methods: The medical records of patients with SCLC, diagnosed and treated at the Oncology Unit of Sotiria Athens General Hospital from January 2015 until June 2017, were retrospectively reviewed. Baseline demographic, clinicopathological and laboratory features of patients, including somatometric variables, Charlson comorbidity index, ECOG performance status (PS), disease stage, presence of metastases, large vessel infiltration, complete blood count parameters and treatment data were correlated with the occurrence of venous thromboembolic events.
Results: A total of 217 patients, with a median age of 67.9 years were included. The majority of cases (81.1%) were male, active smokers (72.3%), and had extensive disease at presentation (70.0%). The cumulative incidence of VTE was 4.1%; 66.7% and 33.3% of these patients developed pulmonary embolism or deep vein thrombosis, respectively. Body mass index (BMI) was correlated with VTE, with obese patients demonstrating higher rates of venous thromboembolic events (p= 0.017). In multivariate analysis, higher BMI values were significantly correlated with increased VTE risk [HR (95% CI): 1.18 (1.01- 1.36); p=0.032].
Conclusions: Obesity may represent an independent predictor of VTE development in SCLC. Prospective studies are warranted to confirm this observation.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3455.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020