Abstract
Background: A subgroup of patients with PBC has concomitant lung involvement. Occasionally lung involvement (LI) occurs first and/or predominates in the clinical course. The objective of our trial was to assess association of LI with other clinical and laboratory signs in PBC.
Methods: 68 patients with PBC divided into 2 groups (with and without LI) were observed in Tareev clinic (Sechenov University) in 2018-2020. Diagnosis, age, gender, clinical and laboratory signs have been compared in both groups.
Results: Computed tomography revealed LI in 36 (52,9%) cases: 27 – interstitial lung disease (ILD), 4 – multiple nodular lesions, 3 – combined interstitial and nodular lesions and 2 – bronchiolitis. Intrathoracic lymphadenopathy was observed in 15 (22.1%) patients. Among all patients with ILD, 6 (8.8%) had CT-pattern of organizing pneumonia, 1 (1.5%) – non-specific interstitial pneumonia, 1 (1.5%) – usual interstitial pneumonia, 9 (13.2%) – undifferentiated interstitial pneumonia and 9 (13.2%) – sarcoid-like pattern of ILD. Such laboratory tests as ESR (41.3±19.1 and 30.3±20.2 mm/h with and without LI; p = 0.025), IgM level (3.80±2.53 and 2.49±2.27 g/l with and without LI; p <0,05) were higher in patients with LI. 10 (27.8%) of all patients with LI had pulmonary onset of the disease. We noted a tendency to a higher level of IgM in patients with pulmonary onset of PBC compared to liver onset (4.93±3.55 and 3.23±1.69 g/l, respectively) although the difference was not significant, mainly due to small group size.
Conclusion: The results indicate the association between the presence of LI and some laboratory features in patients with PBC. Some patients may have pulmonary onset that must be taken into account in the diagnosis of this disease.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3397.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020