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Combined cell therapy and anticoagulants for acute respiratory distress syndrome

Marta Camprubí-Rimblas, Aina Areny, Raquel Guillamat-Prats, Luis Morales-Quinteros, Neus Tantinyà, Josep Bringué, Lluís Blanch, Antonio Artigas
European Respiratory Journal 2020 56: 3347; DOI: 10.1183/13993003.congress-2020.3347
Marta Camprubí-Rimblas
1Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Sabadell, Spain
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  • For correspondence: mcamprubi@tauli.cat
Aina Areny
2Institut d' Investigació i Innovació Parc Taulí (I3PT), Sabadell, Spain
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Raquel Guillamat-Prats
2Institut d' Investigació i Innovació Parc Taulí (I3PT), Sabadell, Spain
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Luis Morales-Quinteros
3Servicio de Medicina Intensiva, Hospital Universitario Sagrat Cor, Sabadell, Spain
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Neus Tantinyà
1Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Sabadell, Spain
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Josep Bringué
1Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Sabadell, Spain
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Lluís Blanch
2Institut d' Investigació i Innovació Parc Taulí (I3PT), Sabadell, Spain
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Antonio Artigas
2Institut d' Investigació i Innovació Parc Taulí (I3PT), Sabadell, Spain
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Abstract

Background: Recent evidence suggests the beneficial effects of cell therapies and nebulized anticoagulants for acute respiratory distress syndrome (ARDS).

Aim: Determine the therapeutic benefit of a combined cell therapy (alveolar type II cells (ATII), mesenchymal stem cells (MSC), supernatant (SN) ATII, SN MSC) with antithrombin in vitro in a coculture of ATII and alveolar macrophages injured with lipopolysaccharide (LPS).

Methods: Cocultured ATII and alveolar macrophages isolated from rat lungs were injured with LPS (10 ng/ml). Two hours after the injury a combined cell therapy (ATII, MSC, SN ATII, SN MSC) with antithrombin (0.1 ng/ml) was administered. Proinflammatory mediators and coagulant factors were analyzed via qRT-PCR at 18 h. Data are expressed as mean±SEM. Statistical analysis was performed using One-Way-ANOVA and Bonferroni post-hoc test (statistical significance p≤0.05).

Results: Proinflammatory mediators and coagulant factors were significantly increased after LPS administration. After administering the different treatments compared the expression of IL1β, IL6, TF PAI-1 and Plasminogen was not as high as in the LPS group.

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Conclusions: The results indicate that combined cell therapy with antithrombin are able to attenuate inflammation and coagulation in vitro in a coculture of ATII and macrophages. Both treatments together are able to face different processes involved in lung injury.

  • Anti-inflammatory
  • Monocyte / Macrophage
  • Epithelial cell

Footnotes

Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3347.

This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2020
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Combined cell therapy and anticoagulants for acute respiratory distress syndrome
Marta Camprubí-Rimblas, Aina Areny, Raquel Guillamat-Prats, Luis Morales-Quinteros, Neus Tantinyà, Josep Bringué, Lluís Blanch, Antonio Artigas
European Respiratory Journal Sep 2020, 56 (suppl 64) 3347; DOI: 10.1183/13993003.congress-2020.3347

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Combined cell therapy and anticoagulants for acute respiratory distress syndrome
Marta Camprubí-Rimblas, Aina Areny, Raquel Guillamat-Prats, Luis Morales-Quinteros, Neus Tantinyà, Josep Bringué, Lluís Blanch, Antonio Artigas
European Respiratory Journal Sep 2020, 56 (suppl 64) 3347; DOI: 10.1183/13993003.congress-2020.3347
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