Abstract
Background: Eosinophilic inflammation is a potential endotype of chronic obstructive pulmonary disease (COPD), however, the baseline clinical characteristics of eosinophilic COPD remains unclear.
Aim: We aim to investigate the clinical characteristics of eosinophilic COPD with blood eosinophils counts (BEC) >2% and 150 cells/uL compared to non-eosinophilic COPD in a real world cohort.
Methods: We prospectively collected stable COPD patients in a single regional hospital. Bronchoalveolar lavage (BAL) were collected for airway micro-organism analysis via conventional culture. FeNO and blood sample were also collected before the procedure. The associated clinical information were also collected for analysis.
Results: A total of 67 adult patients (age > 40 years) with the diagnosis of COPD were included for analysis. Of them, 30 patients with eosinophilic COPD had significantly higher blood eosinophils (5.27%) versus 37 patients with lower eosinophil count (1.54%). We found that only ex-smoker and history of diabetes mellitus (DM) were at high risk of eosinophilic COPD. Nevertheless, the BAL eosinophil counts, FeNO, and serum IgE level were mild increased in eosinophilic COPD group, but not did reach the statistical significance. Moreover, the airway potential pathogenic micro-organism (PPM) colonization were similar in the two groups.
Conclusion: Our study demonstrated that eosinophilic COPD are more likely occurred in ex-smoker and those with DM. Atopic markers (serum IgE and FeNO) and airway PPM were not associated with eosinophilic COPD.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3277.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020