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Clinical factors associated with baseline blood eosinophils among patients with asthma or COPD: NOVELTY study

Hana Müllerová, Donna K Finch, Alvar Agustí, Marianna Alacqua, Gary P Anderson, Richard Beasley, Laura Belton, Alex De Giorgio-Miller, J Mark Fitzgerald, Rod Hughes, Ian D Pavord, David Price, Eleni Rapsomaniki, Mohsen Sadatsafavi, Jørgen Vestbo, Elisabeth H Bel
European Respiratory Journal 2020 56: 2990; DOI: 10.1183/13993003.congress-2020.2990
Hana Müllerová
1AstraZeneca, Cambridge, United Kingdom
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  • For correspondence: hana.muellerova@astrazeneca.com
Donna K Finch
2Biopharma R&D, AstraZeneca, Cambridge, United Kingdom
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Alvar Agustí
3Respiratory Institute, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERES, Barcelona, Spain
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Marianna Alacqua
1AstraZeneca, Cambridge, United Kingdom
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Gary P Anderson
4Lung Health Research Centre, Department of Pharmacology and Therapeutics, University of Melbourne, Victoria, Australia
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Richard Beasley
5Medical Research Institute of New Zealand, Wellington, New Zealand
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Laura Belton
1AstraZeneca, Cambridge, United Kingdom
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Alex De Giorgio-Miller
1AstraZeneca, Cambridge, United Kingdom
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J Mark Fitzgerald
6Centre for Heart and Lung Health, The Lung Centre Vancouver General Hospital, UBC Institute for Heart and Lung Health, Vancouver, Canada
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Rod Hughes
1AstraZeneca, Cambridge, United Kingdom
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Ian D Pavord
7Respiratory Medicine Unit and Oxford Respiratory NIHR BRC, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
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David Price
8Observational and Pragmatic Research Institute, Singapore, and Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom
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Eleni Rapsomaniki
1AstraZeneca, Cambridge, United Kingdom
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Mohsen Sadatsafavi
9Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
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Jørgen Vestbo
10University of Manchester and Manchester University NHS Foundation Trust, Manchester, United Kingdom
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Elisabeth H Bel
11Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, Netherlands
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Abstract

Background: Blood eosinophil count (bEOS) is an important biomarker in obstructive lung disease. NOVELTY (NCT02760329) is a global, prospective, observational study with potential to identify obstructive lung disease phenotypes associated with differential outcomes, using biomarkers and clinical features.

Objective: To evaluate factors associated with bEOS in patients with either physician-assigned asthma or COPD in NOVELTY.

Methods: A cross-sectional analysis of associations between a single bEOS measurement and other baseline characteristics was performed using univariate and multivariate regression models.

Results: Of 4,538 patients with data, the geometric mean (SE) bEOS was 0.16 (0.002) x109/L. Of these, 864 (19%) had EOS ≥300 cells/µL (23% asthma; 14% COPD). High bEOS was positively associated with male sex, ≥2 symptom worsenings in prior 3 months, FeNO, FEV1 reversibility, obesity and frequent mucoid cough, in both asthma and COPD (Figure). For asthma, positive associations with higher bEOS were observed for reduced lung function and physician-assessed severity; for COPD, positive associations were observed with current/former smokers. Associations with FeNO and frequent mucoid cough persisted in multivariate models for both diagnoses.

Conclusions: Higher bEOS was independently associated with higher FeNO and presence of frequent mucoid cough regardless of physician-assigned asthma or COPD.

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  • Biomarkers
  • Asthma - mechanism
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Footnotes

Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2990.

This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2020
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Clinical factors associated with baseline blood eosinophils among patients with asthma or COPD: NOVELTY study
Hana Müllerová, Donna K Finch, Alvar Agustí, Marianna Alacqua, Gary P Anderson, Richard Beasley, Laura Belton, Alex De Giorgio-Miller, J Mark Fitzgerald, Rod Hughes, Ian D Pavord, David Price, Eleni Rapsomaniki, Mohsen Sadatsafavi, Jørgen Vestbo, Elisabeth H Bel
European Respiratory Journal Sep 2020, 56 (suppl 64) 2990; DOI: 10.1183/13993003.congress-2020.2990

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Clinical factors associated with baseline blood eosinophils among patients with asthma or COPD: NOVELTY study
Hana Müllerová, Donna K Finch, Alvar Agustí, Marianna Alacqua, Gary P Anderson, Richard Beasley, Laura Belton, Alex De Giorgio-Miller, J Mark Fitzgerald, Rod Hughes, Ian D Pavord, David Price, Eleni Rapsomaniki, Mohsen Sadatsafavi, Jørgen Vestbo, Elisabeth H Bel
European Respiratory Journal Sep 2020, 56 (suppl 64) 2990; DOI: 10.1183/13993003.congress-2020.2990
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