Abstract
Among Tidal Breathing Flow Volume (TBFV) parameters, tPTEF/tE is a reproducible marker of airway obstruction associated with infants’ wheezing. Few studies evaluated tPTEF/tE in preterm infants in association with respiratory outcomes post-discharge.
Objectives: 1) characterise tPTEF/tE over the first 2yrs of life; 2) evaluate tPTEF/tE predictive value for hospitalisation for respiratory infections (HRI) in preterm infants ± Bronchopulmonary Dysplasia (BPD).
We retrospectively analysed TBFV measurements performed at 0-6, 6-12 and 12-24months corrected age in 97 infants ≤32wks’ gestation. We assessed the association between tPTEF/tE z-score and subsequent HRI using uni- and multi-variable logistic regressions and compared nested models by likelyhood ratio test (LRT).
tPTEF/tE was lower than normal at all time-points (Fig1), was significantly associated with HRI, particularly in infants without BPD (Fig2), and significantly added to BPD classifications alone in predicting HRI (LRT p < 0.001).
Preterm infants present a persistent airway obstruction over the first 2yrs. tPTEF/tE predicts HRI and may be of particular interest for identifying infants at risk without BPD.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2825.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020
