Abstract
Introduction: In recent years, the identification of non-tuberculous mycobacteria has become more frequent in the lung resection material of patients operated on for tuberculosis.
Aim: To study the morphological features of non-tuberculous mycobacteriosis in the lung resection material of patients operated on for respiratory tuberculosis.
Methods: Investigated the lung resection material of 68 patients. All patients were operated on for pulmonary tuberculosis. In the resection material for molecular genetic methods, various strains of non-tuberculous mycobacteria have been identified. A morphological study of the tuberculosis process was performed. Changes in lung tissue characteristic of non-tuberculous mycobacteriosis were highlighted.
Results: In the lung resection material of patients, predominantly slowly growing non-tuberculous mycobacteria were identified: M. avium, M. intracellulare, M. kansasii, M. gordonae, M. xenopi. A hysthological study showed the presence of extensive areas of loose histiocytic macrophage granulomas without necrosis. Granulomas merged into conglomerates and underwent diffuse fibrotization. In these zones, a high concentration of acid-resistant mycobacteria was noted. Characteristic changes were observed with all forms of the pathological process in the lungs: disseminated, focal, fibrous-cavernous.
Conclusion: The results obtained indicate the activation of lung tissue sclerosis in patients with a simultaneous combination of tuberculosis and non-tuberculous mycobacteriosis.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2796.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020