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Prognostic value of plasma level of high mobility group box-1 in sepsis and septic shock

Hongseok Yoo, Jin Young Lee, June Sun Park, Chaiyoung Lee, Kyeongman Jeon
European Respiratory Journal 2020 56: 2745; DOI: 10.1183/13993003.congress-2020.2745
Hongseok Yoo
Samsung Medical Center, Seoul, Republic of Korea
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  • For correspondence: hongseok.yoo@gmail.com
Jin Young Lee
Samsung Medical Center, Seoul, Republic of Korea
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June Sun Park
Samsung Medical Center, Seoul, Republic of Korea
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Chaiyoung Lee
Samsung Medical Center, Seoul, Republic of Korea
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Kyeongman Jeon
Samsung Medical Center, Seoul, Republic of Korea
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Abstract

Background: Although recent studies have suggested that plasma level of high mobility group box-1 (HMGB1), a pro-inflammatory damage associated molecular pattern (DAMP), may be associated with mortality of sepsis, the results are contradictory. Moreover, the relationship between HMGB1 and necroptosis, a programmed cell necrosis mechanism, is not known.

Objectives: The aim of this study was to analyze the association between plasma level of HMGB1 and sepsis severity and outcomes. Furthermore, the plasma level of HMGB1 was compared to that of RIPK3, a key executor of necroptosis, to identify any correlation between HMGB1 and necroptosis.

Methods: This was a prospective observation study on consecutive critically-ill patients admitted to the medical intensive care unit of Samsung Medical Center between 2014 and 2016. HMGB1 and RIPK3 was measured from plasma by ELISA.

Results: Of 188 critically ill patients, 58 (30.9%) and 84 (44.7%) patients were diagnosed with sepsis and septic shock, respectively. A statistically significant trend of increased plasma level of HMGB1 across the groups of control, sepsis, and septic shock was observed (2.4 ng/mL vs. 3.1 ng/mL vs. 5.7 ng/mL, P < 0.001). For 142 patients with sepsis, the group with high plasma HMGB1 was more likely to have septic shock and higher severity of illness scores. In addition, higher 28-day, in-hospital, and 90-day mortalities were observed in the high HMGB1 group. There was a strong correlation between plasma level of HMGB1 and RIPK3 (R2 = 0.6516, P < 0.001).

Method: Plasma level of HMGB1 was associated with severity and outcomes of sepsis. Plasma level of HMGB1 was correlated with plasma level of RIPK3.

  • Biomarkers
  • Critically ill patients
  • Sepsis

Footnotes

Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2745.

This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2020
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Prognostic value of plasma level of high mobility group box-1 in sepsis and septic shock
Hongseok Yoo, Jin Young Lee, June Sun Park, Chaiyoung Lee, Kyeongman Jeon
European Respiratory Journal Sep 2020, 56 (suppl 64) 2745; DOI: 10.1183/13993003.congress-2020.2745

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Prognostic value of plasma level of high mobility group box-1 in sepsis and septic shock
Hongseok Yoo, Jin Young Lee, June Sun Park, Chaiyoung Lee, Kyeongman Jeon
European Respiratory Journal Sep 2020, 56 (suppl 64) 2745; DOI: 10.1183/13993003.congress-2020.2745
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