Abstract
Because of the high prevalence of obstructive sleep apnea (OSA) and its health risks, novel testing methods are crucial.
To screen for serum biomarkers, we aimed at assessing the metabolome in a prospective cross-sectional study on patients with OSA.
We recruited 63 individuals, who underwent polysomnography (PSG). Based on the PSG findings, 31 subjects with moderate-to-severe OSA and 32 controls with an apnea-hypopnea index <15/h were included. Serum samples were obtained at 9:00 p.m., 5:00 a.m. and 7:00 a.m. and subjected to targeted analysis using AbsoluteIDQ® p180 Kit on a liquid chromatography-mass spectrometry to quantitate the continuum of amino acids. The data were compared using rank general linear model for repeated measures and adjusted to BMI, age, sex and smoking status.
Significant up-regulation of alanine and taurine occurred among OSA patients (Figure 1).
Alanine is essential in the Cahill cycle. Elevated taurine blood concentrations have been demonstrated in sleep deprivation. Changes in muscle activity and sleep structure in OSA are well documented. Alanine and taurine may serve as pathophysiologically significant biomarkers in OSA.
Funded by the institutional research grant IUT 20-42 and the EU through the European Regional Development Fund (Project 2014-2020.4.01.15-0012).
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2536.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020
