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Factors associated with physician assessment of severity of asthma or COPD in NOVELTY

Alberto Papi, Helen K Reddel, Alvar Agustí, Gary P Anderson, Aruna T Bansal, Richard Beasley, Elisabeth H Bel, Christer Janson, Barry Make, Ian D Pavord, David Price, Eleni Rapsomaniki, Donna K Finch, Marianna Alacqua, Hana Müllerová, Rod Hughes
European Respiratory Journal 2020 56: 2201; DOI: 10.1183/13993003.congress-2020.2201
Alberto Papi
1Respiratory Medicine Unit, Dept of Medical Sciences, Università di Ferrara, Ferrara, Italy
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  • For correspondence: ppa@unife.it
Helen K Reddel
2Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
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Alvar Agustí
3Respiratory Institute, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERES, Barcelona, Spain
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Gary P Anderson
4Lung Health Research Centre, Department of Pharmacology and Therapeutics, University of Melbourne, Victoria, Australia
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Aruna T Bansal
5Acclarogen, Cambridge, United Kingdom
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Richard Beasley
6Medical Research Institute of New Zealand, Wellington, New Zealand
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Elisabeth H Bel
7Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, Netherlands
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Christer Janson
8Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Barry Make
9National Jewish Health and University of Colorado Denver, Denver, CO, United States of America
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Ian D Pavord
10Respiratory Medicine Unit and Oxford Respiratory NIHR BRC, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
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David Price
11Observational and Pragmatic Research Institute, Singapore, and Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom
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Eleni Rapsomaniki
12AstraZeneca, Cambridge, United Kingdom
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Donna K Finch
13Biopharma R&D, AstraZeneca, Cambridge, United Kingdom
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Marianna Alacqua
12AstraZeneca, Cambridge, United Kingdom
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Hana Müllerová
12AstraZeneca, Cambridge, United Kingdom
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Rod Hughes
12AstraZeneca, Cambridge, United Kingdom
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Abstract

Background: Determinates of how physicians assign severity in asthma or COPD are poorly understood. The NOVEL observational longiTudinal studY NOVELTY (NCT02760329) is a global, prospective, 3-year observational study of patients with a physician-assigned diagnosis or suspected diagnosis of asthma, asthma+COPD or COPD.

Objective: To identify factors associated with physician-assigned severity of either asthma or COPD in the NOVELTY population.

Methods: Ordinal regression analysis was used to identify factors associated with higher physician-assigned severity (severe vs mild or moderate; moderate vs mild) at baseline in patients with asthma (n=4,361) or COPD (n=2,931).

Results: Factors associated with higher levels of physician-assigned severity are shown in the figure. Clinical features including exacerbation history in the past year, lower post-bronchodilator FEV1 % predicted, or FEV1/FVC ratio, reversibility and higher mMRC dyspnoea score were associated with greater severity for both diagnoses. Presence of allergic or non-allergic rhinitis or nasal polyps were notable factors in asthma, as was emphysema in COPD.

Conclusions: Greater physician-assigned severity was associated with worse respiratory symptoms, lower lung function and exacerbation history in patients with asthma or COPD in NOVELTY; associations between greater severity and some diagnosis-related features and comorbidities varied between asthma and COPD.

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  • COPD - diagnosis
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Footnotes

Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2201.

This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2020
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Factors associated with physician assessment of severity of asthma or COPD in NOVELTY
Alberto Papi, Helen K Reddel, Alvar Agustí, Gary P Anderson, Aruna T Bansal, Richard Beasley, Elisabeth H Bel, Christer Janson, Barry Make, Ian D Pavord, David Price, Eleni Rapsomaniki, Donna K Finch, Marianna Alacqua, Hana Müllerová, Rod Hughes
European Respiratory Journal Sep 2020, 56 (suppl 64) 2201; DOI: 10.1183/13993003.congress-2020.2201

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Factors associated with physician assessment of severity of asthma or COPD in NOVELTY
Alberto Papi, Helen K Reddel, Alvar Agustí, Gary P Anderson, Aruna T Bansal, Richard Beasley, Elisabeth H Bel, Christer Janson, Barry Make, Ian D Pavord, David Price, Eleni Rapsomaniki, Donna K Finch, Marianna Alacqua, Hana Müllerová, Rod Hughes
European Respiratory Journal Sep 2020, 56 (suppl 64) 2201; DOI: 10.1183/13993003.congress-2020.2201
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