Abstract
We previously reported an association of higher fat mass levels from age 9 to 15 years with lower FEV1/FVC at 15 years (i.e. higher risk of airflow limitation). We aimed to assess whether CRP levels and/or insulin resistance mediate this association.
We included 1385 children from the ALSPAC birth cohort. Four fat mass index trajectories (‘low’, ‘medium-low’, ‘medium-high’, ‘high’) from 9 to 15 years were previously identified using Group-based Trajectory Modelling. Data on CRP, glucose, insulin and FEV1/FVC were available at 15 years. We used glucose and insulin to define insulin resistance by means of the homeostatic model assessment (HOMA) index. We used linear regression models (adjusted for maternal social class, smoking during pregnancy and child’s sex, age, height, pubertal status, duration of breastfeeding and FEV1/FVC at 8 years) and the ‘mediate’ package in ‘R’.
We found no evidence that CRP played a role in the association of fat mass and FEV1/FVC at 15 years. We observed an indirect effect (mediation) of insulin resistance only when comparing the ‘high’ to ‘low’ fat mass index trajectories (mean difference [95%CI]: -0.38% [-0.76, -0.03]; figure 1).
The association of fat mass and airflow limitation at 15 years may be mediated (at least in part) by insulin resistance. We found no evidence of an influence of CRP.
Method: ALEC (EU H2020 Grant #633212)
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2063.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020