Abstract
Background: Sensitization to Staphylococcal enterotoxin (SE) is associated with pulmonary function in asthma. However, its association with colonization of Staphylococcus aureus (S. aureus) in lower airway is unknown.
Aims: To clarify an association between sensitization to SE and S. aureus colonization in lower airway in patients with bronchiectatasis whose lower airway tends to be colonized by pathological bacteria.
Methods: In this retrospective, single center study, we examined patients with bronchiectasis determined based on the chest computed tomography finding [modified Reiff (mReiff) score ≥1]. Associations of sensitization to SE with clinical indices including sputum culture results were analyzed. Associations between severity of bronchiectasis and clinical indices including pulmonary function and bacteria in sputum were also analyzed.
Results: In 45 patients (mean 71 years old, 35 females), frequency of sensitization to SE was 18%. Sensitization to SE was significantly associated with higher total IgE level. S. aureus was detected in 37% of patients and its detection was significantly associated with sensitization to SE (p = 0.04). Pseudomonas aeruginosa (P. aeruginosa) was detected in 40% of patients. Although mReiff score was unrelated to detection of S. aureus in sputum, mReiff score was the highest in patients with P. aeruginosa only, followed by those with P. aeruginosa and S. aureus, neither of the bacteria, and S. aureus only in this order, with significant difference among the 4 groups. As expected, mReiff score was significantly and negatively correlated with %FEV1.
Conclusion: Sensitization to SE occurs in patients with bronchiectasis and might reflect microbiome in lower airway.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2052.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020