Abstract
Introduction: Pneumococcal infection is a serious problem in modern medicine. For the treatment of pneumococcal infections, drugs of the beta-lactam group and macrolides are most often used.
Objective: to analyze the dynamics of antibiotic resistance of nasopharyngeal pneumococcus isolates in children.
Materials and Methods: The study included pneumococcal isolates from children under 5 years old from 2010 to 2018. Sensitivity to antibiotics was determined by the disk diffusion method and using E-tests. The ermB and mef resistance genes were determined in erythromycin-resistant isolates by PCR.
Results: We studied 708 samples of pneumococcus obtained from children under 5 years old. The results of the study revealed a high percentage of resistance to Oxacillin (31.8%), Erythromycin (35.1%) and Co-trimoxazole (52.5%). Β-lactam resistance increased from 20% in 2010/11 to 27% in 2018.The greatest increase in resistance was observed to Erythromycin from 26.7% in 2010/11. up to 40% in 2018. The increase in resistance is mainly associated with non-vaccine serotypes (6C, 11A, 15A, 15B / C, 23A, 35F). More than 55% of pneumococci of serotypes 14, 19A and 19F had the phenotype of multidrug resistance. Serotype 6B pneumococci in 56% were not sensitive to Erythromycin. A study of the macrolide resistance genotype showed that 82% of Erythromycin-resistant pneumococci carried the ermB gene (alone or in combination with the mef gene). All Penicillin-resistant isolates were Erythromycin resistant.
Conclusions: the total prevalence of pneumococci resistant to Penicillin and Erythromycin was 7.3%. Increased resistance has been associated with non-vaccine serotypes.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2038.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020